Activation of c-Jun N-terminal Kinases by Ribotoxic Stresses

(整期优先)网络出版时间:2005-06-16
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Thec-JunN-terminalkinases(JNKs)areclassicstress-activatedproteinkinases.ManycellularstresseshavebeenshowntostimulateJNKactivation.Inthisreview,wefocusonribotoxicstressesbasedontheirmultiplebiologicalpotenciesincludinganti-HIV-1activity.Someofthefunctionsofribotoxinsandthesignalingtransductionpathwaythatmediatedarementioned.Differentfromotherstimulators,ribotoxicstressesactonspecialmotifsof28SrRNAintranslationallyactivemammalribosomes.BindinganddamagingonthemotifleadstoJNKactivationandsubsequentlybiologicalresponsetothesignalinitiator,whichisnamedribotoxicstressresponse.