hearing and cochlear structures in a swine model

(整期优先)网络出版时间:2010-02-12
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ObjectiveTostudytheauditionandinnerearstructureinanormalswinemodel.MethodsAuditorybrainstemresponses(ABRs)weredeterminedinswineat1dayand1monthafterbirth.Theformofthecochleaandhaircellswereexaminedunderascanningelectronmicroscopeandoncochlearslices.ResultsABRthresholdsat1dayand1monthpost-birthwerebetween40and50dBSPL.ThelatenciesofwavesI,IIIandVin1dayoldswinewere1.97±0.13,3.01±0.16and4.26±0.20ms,respectively.At1month,thelantanciesofwavesI,IIIandVwere2.01±0.05,3.11±0.08and4.65±0.14ms,respectively,slightlylongerthanthoseat1day,althoughnotstatisticallysignificant(p>0.05).Theswinecochleawasconstitutedof3andahalfturnsandthecochlearhaircellslinedupinfourrows.Haircellciliaintheapicalturnwerelongerthanthoseinotherturns.ConclusionsTheswinecochleaismatureatthetimeofbirth.SwineABRthresholdsareslightlyhigherthanhumansandrats.Swineappearstobeaprecocialanimalspecies.