Anewalgorithmofnonuniformitycorrectionforinfraredfocalplanearray(IRFPA)isreported,whichisacombinedalgorithmbasedonboththetwo-pointcorrectionandartificialneuralnetworkscorrection.Thecombinedalgorithmiscalibratedbytwo-pointcorrection,andthecalibratedcorrectioncoefficientsareautomaticallymodifiedbyBPalgorithm.Soitisnotonlycalibrated,butalsoreal-timeprocessed.Inadaptivenonuniformitycorrectionalgorithm,thephenomenaghostartifactandtargetfade-outareavoidedbyedgeextraction.Inordertogetintensifiedimage,themodifiedmedianfiltersareadopted.Thesimulateddataindicatestheproposedschemeisaneffectivealgorithm.