Theselectionofelectro-acupunctureparametersremainspoorlyunifiedbetweenclinicalstudies.Thepresentstudyobservedtheeffectsofelectro-acupuncturingRenzhong(DU26)withdifferentstimulationparametersonmotorfunctionrecoveryfollowingmiddlearteryocclusioninjuryinrats.ResultsshowedanoptimalstimulationparameterforRenzhongelectro-acupuncturethatwaslowfrequencyandmildcurrent(2Hz,1mA)significantlyimprovedcorticalexcitabilityandconductivefunction,andpromotedrecoveryinaratmodelofmotorfunctioninmiddlearteryocclusion.Frequencyhadagreaterimpactthancurrentorinteraction,andplayedacriticalroleinelectro-acupuncturetherapy.