学科分类
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1 个结果
  • 简介:Telomeraseactivitywasinhibitedinadoseandtime-dependentmannerwiththetreatmentofcisplatinfor24,48,or72hinaconcentrationrangedfrom0.8to50μMinBEL-7404humanhepatomacells.Therewerenochangesinexpressionpatternofthreetelomerasesubunits,itscatalyticreversetranscriptasesubunit(hTERT),itsRNAcomponent(hTR)ortheassociatedproteinsubunit(TP1),aftercisplatintreatedfor72hwithindicatedconcentrations.Meantelomerelengthsweredecreasedbythecisplatintreatment.CellgrowthinhibitionandcellcycleaccumulationinG2/Mphasewerefoundtobecorrelatedwithtelomeraseinhibitioninthepresentstudy,butpercentagesofcellapoptosisdidnotchangemarkedlyduringtheprocess.

  • 标签: 肝细胞癌 BEL-7404人肝癌细胞系 端粒长度 端粒酶活性 二氨二氯络铂