简介：SmallRNA(sRNA)-mediatedpost-transcriptionalregulationdiffersfromprotein-mediatedregulation.Throughbasepairing,sRNAcanregulatethetargetmRNAinacatalyticorstoichiometricmanner.Sometheoreticalmodelswerebuiltforcomparisonoftheprotein-mediatedandsRNA-mediatedmodesinthesteady-statebehaviorsandnoiseproperties.ManyexperimentsdemonstratedthatasinglesRNAcanregulateseveralmRNAs,whichcausescrosstalkbetweenthetargets.Here,wefocusonsomemodelsinwhichtwotargetmRNAsaresilencedbythesamesRNAtodiscusstheircrosstalkfeatures.Additionally,thesequence-functionrelationshipofsRNAanditsroleinthekineticprocessofbase-pairinghavebeenhighlightedinmodelbuilding.

简介：Recently,RNAprocessinghasemergedasanovelpathwaythatmaycontributetothemaintenanceofgenomestability[1].Alternativesplicingisakeymolecularmechanismforincreasingthefunctionaldiversityoftheeukaryoticproteomes,butitalsooftenalteredincancer.Mountingevidenceindicatesthatalternativesplicing,theprocessthatallowsproductionofmultiplemRNAvariantsfromeachgene,contributestotheheterogeneityofthedisease[2].Althoughthemechanismofalternativesplicingvariantincancerisunclear,thecancer-specificalternativesplicingvariantshavebeenobservedinavarietyofhumancancersandcancercelllinesandhavebeenconnectedtotumorgenesis.

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简介：介绍当前对抗性病毒的特征、传播方式、实现的主流技术手段、表现形式和应对策略,给出建立防范对抗性病毒的标准应用模式和防范该类病毒的主要技术手段和管理措施。