简介:New[1+1]and62-membered[2+2]Schiffbasemacrocyclescontaininga2,6-diamidopyridinesubunithavebeensynthesizedbycondensationreactionoftheprecursorspyridine-2,6-dicarboxamideand1,10-bis(20-formylphenyloxy)decaneinthepresenceofphosphoricacidviaaone-potprocess.Thecyclocondensedproductswereeffectivelyisolatedbygelcolumnchromatographyandcharacterizedby~1HNMR,FTIR,massspectrometryandX-rayanalysis.Thetwomacrocycleshaveatwistedstructure,andnotanopen‘circular’conformationinthesolidstate.
简介:AseriesofnovelN-(3-furan-2-yl-1-phenyl-1H-pyrazol-5-yl)amidesderivativesweredesignedandsynthesized.Theirstructureswereconfirmedby1HNMR,13CNMRandHRMS.Alltitlecompoundswereevaluatedfortheirherbicidalandantifungalactivities.Preliminarybioassayresultsindicatedthatthetitlecompoundsshowedgoodtomoderateherbicidalactivityat1000mg/L.Compound6qpresentedthebestactivityagainstDigitariasanguinalis(L)Scop.,AmaranthusretroflexusL.andArabidopsisthalianawithaninhibitiondegreeoffive.Compound6dalsoshowedaninhibitiondegreeoffiveagainstD.sanguinalis.Inaddition,at50mg/L,mostcompoundsexhibitedgoodinvitroantifungalactivityagainstSclerotiniasclerotiorum,withcompound6cshowingover90%antifungalactivityagainstS.sclerotiorumandPelliculariasasakii.
简介:Nitricoxidehasplayedanimportantroleinmanyphysiologicalandpathologicalprocessesasakindofimportantgassignalmolecules.Inthiswork,anewfluorescentprobeLysoNO-NaphfordetectingNOinlysosomesbasedon1,8-naphthalimidewasreported.LysoNO-Naphhassub-groupsofo-phenylenediamineasaNOreactionsiteand4-(2-aminoethyl)-morpholineasalysosome-targetablegroup.Thisprobeexhibitedgoodselectivityandhighsensitivity(4.57mmol/L)towardNOinawidepHrangefrom4to12.Furthermore,LysoNO-NaphcanbeusedforimagingNOinlysosomesinlivingcells.
简介:利用水热工艺,选用有机配体3,3’,5,5’-四甲基-4,4’-联邻二氮杂茂(H2X)和CuCl2·2H2O为起始原料,合成了1个新的多酸基杂化化合物[Cu2(H2X)2(Mo6O19)]·2H2O被合成.采用X-射线单晶衍射、红外光谱、元素分析和热重分析等手段对该化合物的结构进行了表征.单晶测试结果表明该化合物为1D链状化合物,属于三斜晶系,P-1空间群,晶胞参数a=0.9469(3)nm,b=0.9544(3)nm,c=2.0599(6)nm,α=90.717(4)°,β=93.518(5)°,γ=102.802(4)°,V=1.8112(9)nm3,Z=4,R1=0.0829,wR2=0.1512.
简介:利用L-脯氨酸催化的5-氯水杨醛(1)与6-甲基-4-羟基吡喃酮(2)的缩合反应及硫酸铜催化下与1,3-二甲基-5-氨基吡唑(3)的串联反应,合成得到了10-氯-1,3-二甲基-5-(2-氧代丙基)色烯并[4,3-d]吡唑并[3,4-b]吡啶-6(3H)-酮(4)和10-氯-5-二乙氧基甲基-1,3-二甲基色烯并[4,3-d]吡唑并[3,4-b]吡啶-6(3H)-酮(5).化合物5的结构通过单晶X射线衍射法确定:晶体属于三斜晶系,空间群P-1;相对分子质量Mr=803.68;晶胞参数a=1.03160(10)nm,b=1.42900(13)nm,c=1.44268(15)nm;V=1.9448(3)nm~3;Z=2;晶胞密度Dc=1.372g/cm~3;吸收系数μ=0.228mm-1;单胞中电子的数目F(000)=840.晶体结构用直接法解出,经全矩阵最小二乘法对原子参数进行修正,最终的偏离因子为R=0.0681,wR=0.2051.在晶体结构中色烯环与吡啶环及吡唑环近似于共平面.