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简介:客观:cross-linked生产,它被准备由哈并且cross-linking代理人STMP,EDC,通过cross-linking反应的GP,可能在药交货系统(DDS)被使用。保证临床的申请的安全,优秀性质象没有房间毒性那样,nonirritant,没有将军毒性,没有免疫学的拒绝是必要的。方法:根据GB/T的请求,16886.1在医药biomaterials,房间毒性测试,溶血测试,intracutaneous刺激测试,尖锐毒性测试,和过分敏感的测试的安全评估上被要求。结果:HA-STMP的房间毒性,HA-EDC,HA-GP都是不到1。所有过分敏感的测试是合格的。但是HA-EDC,忽视的生产的不同的度激动的HA-GP,细微毒性,溶血率,它比标准价值大。结论:HA-STMP拥有赞成biocompatibility,它是一种理想的biomaterials和药搬运人。
简介:客观:在乙醇的媒介(非极),是的STMP和ADH,以由没有一个胶化阶段,得到稳定的cross-linked产品准备药交货microspheres,并且学习cross-linked产品的biocompatibility和biodegradability的crosslinkers哈。方法:是的生物医学的材料的ISO10993.1安全评估一本参考书,做溶血测试,经皮的刺激测试,vitro降级测试,和降级产品的尖锐毒性测试,和分析。结果:HA-STMPcross-linked产品没把溶血,没有激怒,没有尖锐全身的毒性,而是HA-ADH有温和皮肤激怒和不利尖锐全身的毒性。HA-STMPcross-linked产品HAse和曲线上的有的更低的敏感是flatting。随HA-STMP结果被结构分析改变的降级时间的增加,这些房间的降级产品不是毒性。结论:有到水解作用的更好的biocompatibility和更好的抵抗的HA-STMPcross-linked产品能推迟降级时间,它对可被细菌破坏的药搬运人的准备合适。
简介:Objective:Preparecross-linkedHAgelswithhighermechanicalstability,lowerdegradationvelocityanddesirablebiocompatibility,soastoextendtheusageofHA.Method:1.TestmolecularweightofHA(MrHA)byviscosimetry;2.Preparecross-linkedHAgelsbyDVS,GTA,DEC;3.Discussthecross-linkinganddegradationprocedure;4,evaluatethebiocompatibilityofthebestHAgels.Results:ThemechanicalstabilityanddurabilitytodegradationofHA-DVSgelsaresuperiortothoseofothergels,andwhenHA:DVS=40:1(g/g),at35℃andin0.2MNaOHsolution,theHA-DVSgelshowsthebestmechanicalstability,anditscytotoxicityreachesclassI,hemolysisratioislowerthan5%.Conclusion:OurHADVSgelcanbeusedtopreparebiologicscaffolds.
简介:ASTUDYONTHEPARAWALKERCONTROLLEDBYEMGASTUDYONTHEPARAWALKERCONTROLLEDBYEMGWangRencheng;ZhangPeiyu;ZhangJichuan;JinDewen(Dept.of...
简介:STUDYONSOLUBILITYOFAPATITECERAMIESINVITROSTUDYONSOLUBILITYOFAPATITECERAMIESINVITROL.NingM.Xue(ShanghaiSecondMedicalUniversity...
简介:Thetechniqueofcomputersimulationsisaveryefficientmethodininvestigatingmechanismsofmanydiseases.Thispaperreviewshowthesimulationsofthehumanheartstartedasasimplemathematicalmodelsinthepastanddevelopedtothepointwheregeneticinformationisneededtodosuitableworklikefindingoutnewmedicamentsagainstheartdiseases.AlsotheInfluenceofthedevelopmentofcomputerperformanceinthefutureaswellasthedatapresentationisdescribed.
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简介:ANEWMETHODFORSTUDYOFERYTHROCYTESEDIMENTATIONANEWMETHODFORSTUDYOFERYTHROCYTESEDIMENTATIONZhaoZhiyun;FanJiajun;YangChunzhi;WenJ...
简介:STUDYONMECHANISMOFTHEBIOEFFECTSOFTRANSIENTELECTROMAGNETICPULSESTUDYONMECHANISMOFTHEBIOEFFECTSOFTRANSIENTELECTROMAGNETICPULSEW...
简介:Collagenisthemajoracellcarofconnectivetissueproteininanimals,accountingforabout25%ofthetotalbodyproteinofvertebrates.Anessentialfeatureofthistypeofbiomaterialisthatitdegradesinbiologicenvironments,eventuallydisap-pears,andleavesnopermanentforeignresidue.Averypracticalaspectoftheuseofcollagenisitseaseofpreparationanditswidespreadoccurrenceinnature.Thus,col-lagenhasbeenemployedasabiomaterialinalmosteveryphysicalform.Forexam-ple,collagenfibrescanbeusedasasubstratefornerveregeneration,tendonligament
简介:Recently,manyresearchesontherepairofperipheralnervebytheaidofnerveregenerationconduitmethodwerecarriedoutandgoodprogresseswereattained.Itwasbelievedthattheconduitshouldbemadefrombiodegradablebiomaterial.
简介:客观:到为在非细胞组成的牛的心包的准备的最好的过程的搜索,为构造织物工程方法提供脚手架给那么:牛的心包与5个方法被对待,它被划分成6groups.GroupA:新鲜bovinepericardium;GroupB:Trypsin-detergentgroup;GroupC:Freeze-thaw-detergent24h组;组D:.Freeze-thaw-detergent48h组;组E:Freeze-thaw-nuclease组;组F:净化核酸酶的group.Then,由他观察th的染色并且扫描的电子显微镜
简介:Thispaperpresentsanovelmethodofspotaddressingandsegmentationabouttheforegroundsegmentationofmicroarrayimage.Inthispaper,aspotaddressingmethodbasedonparticleswarmoptimization(PSO),algorithmisproposedtohaveafurthersearchforthecentercoordinateandradiusofthespotwhoseregionisdeterminedbytheprojectionmethod.Then,aforegroundsegmentationmethodisputforwardtomakethespotforegroundsegmentationbasedonthecentercoordinateandradiusofthespot.Thespotaddressingandsegmentationexperimentsonsyntheticandrealmicroarrayimagesshowthattheproposedmethodiseffectiveandfeasiblefortheforegroundsegmentationofmicroarrayimage.
简介:ANEXPERIMENTALSTUDYONTHEHEPARIN-FREEHEMODIALYSISOFHEMOPHANADSORPTIONANEXPERIMENTALSTUDYONTHEHEPARIN-FREEHEMODIALYSISOFHEMOPHA...
简介:学习使用了自然地发生的crosslinkingreagent-genipin化学上修改非细胞组成的牛的心包,准备设计支架材料,和评估genipincrosslinked的心脏的阀门织物由调查纸巾的物理、化学的性质的牛的心包的非细胞组成的矩阵例如表面性质,crosslinking特征,机械性质,抵抗到在vitro的酶的能力,和溶血测试。结果证明有genipin的非细胞组成的牛的心包矩阵crosslinked是强壮的hydrophilicity,高crosslinking索引,和稳定的结构,它能维持好机械性质。作为为阀门织物工程的一种支架材料,它有宽申请前景。
简介:IntermittentPneumaticCompression(IPC)hasbeenusedsuccessfullyforthepreventionofearlypostoperativedeepveinthrombosis(DVT).RecentlyIPChasbeendescribedforthetreatmentoflymphedema,chronicedema,recoveryfromlowerextremityulcersandtheenhancementofwoundhealing.ForgoodapplicationsofIPCinclinic,itisnecessarytostudyitseffectivemechanismfurther.Wemeasuredsome