简介：Epilepsyisacommonneurologicaldisorder,anditselectrophysiologycharacteristicisabnormallyhighexcitabilityandsynchronizationoftheneuralactivity.Thispaperfocusesonthestudyofmedialtemporallobeepilepsywithhippocampalsclerosis.Thehippocampusplaysanimportantroleinshort-termmemory.However,littleisknownabouttheconnectivitybetweenhippocampalstructuresandadjacentbrainregions.Thefunctionalandstructuralconnectivitybetweenpatientsandcontrolswasinvestigatedbyusingthetechniquesoffunctionalmagneticresonanceimaginganddiffusiontensorimaginginthepaper.ThreepairsofROIsrelatedtoworkingmemoryfromBOLD-fMRIdatawerechosen.TheseROIswereregistratedfromMNIspacetoindividualspaceandthefiberbundlebetweentwoROIsweretracedintheDTIimages.TheresultsshowthatthenumberoffiberbundleofpatientsreduceamongtheseROIs,suchaslefthippocampusandrighthippocampus,lefthippocampusandleftthalamus,lefthippocampusandleftfrontallobeandsoon.AndthenumberoffiberbundleofpatientsincreaseamongtheseROIs,suchasleftthalamusandrightthalamus,righthippocampusandrightthalamus.AndtheFAvaluesofthefiberbundlesofpatientsinsomeregionsrelatedtolefthippocampusdecrease.Thecauseofabnormalfunctionalandstructuralconnectionsduetothedamageofhippocampusinmedialtemporallobeepilepsyisstudiedfromanewperspective.