简介：Circulatingfreenucleicacids;cellfreeDNAandcirculatingmicro-RNA,arefoundintheplasmaofpatientswithhematologicandsolidmalignanciesatlevelshigherthanthatofhealthyindividuals.InpatientswithhematologicmalignancycellfreeDNAreflectstheunderlyingtumormutationalprofile,whilstmicro-RNAsreflectgeneticinterferencemechanismswithinatumorandpotentiallythesurroundingmicroenvironmentandimmuneeffectorcells.Thesecirculatingnucleicacidsofferapotentiallysimple,non-invasive,repeatableanalysisthatcanaidindiagnosis,prognosisandtherapeuticdecisionsincancertreatment.
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