简介：Sincethefailureoftraditionaltherapy,genetherapyusingfunctionalDNAsequenceandsmallRNA/DNAmolecules(oligonucleotide)hasbecomeapromisingavenueforcancertreatment.ThediscoveryofRNAmoleculeshasimpelledresearcherstoinvestigatesmallregulatoryRNAfromvariousnaturalandartificialsourcesanddetermineacogenttargetforcontrollingtumorprogression.SmallregulatoryRNAsareusedfortherapeuticsilencingofoncogenesandaberrantDNArepairresponsegenes.Despitetheiradvantages,therapiesbasedonsmallRNAsexhibitlimitationsintermsofstabilityoftherapeuticdrugs,precisionbaseddeliveryintissues,precision-basedintercellularandintracellulartargeting,andtumorheterogeneity-basedresponses.Inthisstudy,wesummarizethepotentialanddrawbacksofsmallRNAsinnucleicacidtherapeuticsforcancer.