简介：随着互联网技术的发展及其与教育的有机结合，眼科教学面临新的机遇和挑战。应完善基于医疗“大数据”技术、虚拟现实技术和移动互联技术为主要内容的眼科教学方法，提升“互联网＋”背景下眼科教师的教学素养，从而促进学生自主学习、个性化学习，达到提高学习效率、改善学习效果的目的。

简介：目的探讨老年性聋临床听力表现特点。方法选用41例老年性聋患者进行纯音测听检查和言语测听检查（言语识别阈，言语识别率和合成语句检查）。结果纯音听力图以高频缓降和高频陡降为主。静态下言语识别率和合成语句检查得分均高于噪声下言语识别率和竞争声合成语句检查，差异有显著性意义（P〈0．01）。老年性聋纯音听力损害程度与言语识别率不完全一致。结论老年性聋患者不仅有耳蜗、听神经受损和退变，更有中枢分辨能力的蜕化。

简介：目的探讨喉癌前哨淋巴结定位和活检技术的可行性及其对颈淋巴结转移癌的预测价值.方法采用1%专利兰(PatentblueVdye),对31例颈淋巴结N0的喉癌患者进行术中前哨淋巴结定位研究,且对术中前哨淋巴结及颈清扫术切除淋巴结进行常规病理检查和对比,观察前哨淋巴结对颈淋巴结转移癌的预测值.结果3l例中21例找到前哨淋巴结,成功率67.7%,前哨淋巴结对颈淋巴结转移癌的预测值为95.2%.结论喉癌前哨淋巴结的定位和活检技术切实可行,且前哨淋巴结检测能够准确预测颈淋巴结转移癌的状况.

简介：目的:检测白塞氏病(BD)患者和正常人群血浆中微小核糖核酸(microRNA,miRNA)的差异表达谱,探讨miRNA在BD发病中的作用,寻找与BD相关的血浆生物标记物。方法:收集15例活动期BD患者和15例正常人的抗凝静脉血,离心获得血浆,提取总RNA,经miRNA标记、miRNA阵列杂交、miRNA阵列扫描和分析获得BD患者异常表达的miRNA谱。通过miRTarBase(靶基因数据库)检索差异性表达的miRNA已经过验证的靶基因,并选取与免疫学相关的差异性表达的miRNA进行Realtime-PCR验证。结果:活动期BD患者血浆中hsa-miR-34c-5p、hsa-miR-144-3p、hsa-miR-483-3p较正常人表达上调,hsa-miR-301a-3p、hsa-miR-224-5p、hsa-miR-454-3p、hsa-miR-17-5p、hsa-miR-199a-5p较正常人表达下调。结论:miRNA的差异性在BD的发生发展过程发挥重要作用,异常表达的miRNA可能通过Notch1和SMAD4信号通路促进BD发病。

简介：目的：建立适用于本视觉电生理检查室的脑电皮肤电极记录视网膜电图正常值指标,以利于将其用于配合度低的患者。方法：选取2015-03/09来我科检查后诊断为正常者30例51眼,分别采用角膜接触镜电极和皮肤电极记录视网膜电图,对检查结果进行比较分析。结果：两种电极检查结果差异都有统计学意义（P〈0.05）。幅值上皮肤电极结果均明显低于角膜接触镜电极,其占角膜接触镜电极幅值的比值为20%~30%;但潜伏期较角膜接触镜电极稍提前,其占角膜电极记录结果的比值为95%~96%。结论：将脑电皮肤电极用于配合度低的患者可以提供有价值的视网膜功能信息。

简介：AIM:Todescribethedesignandpreliminaryresultsofthehospitalbasedepidemiologicalstudyfordiabeticretinopathy(HBESDR),anongoingepidemiologicalstudytoestimatetheprevalenceofdiabeticretinopathy(DR)andtoelucidatetheclinical,anthropometric,biochemicalandanyotherriskfactorsassociatedwithdiabeticretinopathy.METHODS:Totally2000diabeteswillberecruitedfromtheDiabeteseyeclinicintheFirstAffiliatedHospitalofChinaMedicalUniversity.AllsubjectsunderwentbloodsugarestimationandOralGlucoseToleranceTesttodiagnosediabetes.Alldiabeteswouldundergocompletequestionnaire,acomprehensiveeyeexamination.Bloodandurinewouldbecollectedforbiochemicalinvestigations.AllfundusphotographsforanyDRwillbegraded.Participantswhoneedtreatmentwillbesenttotheophthalmicclinicandfollow-upintervalprogramforallsubjectswillbesuggested.Acomputerizeddatabaseiscreatedfortherecords.RESULTS:Todate,1174diabeteshavebeenrecruited,therewere350(29.81%)DRinalldiabetes,mostofthemwerewithmildnon-proliferativediabeticretinopathy(NPDR)(139,39.71%);71(20.29%)moderateNPDR,66(18.86%)severeNPDR,74(21.14%)proliferativediabeticretinopathy(PDR).Females,longerdurationofdiabetes,familyhistoryofdiabetesandhypertensionhadastatisticallysignificantincreaseinriskofanyDR.CONCLUSION:ThestudyisexpectedtoprovideanestimateoftheoverallprevalenceofDRandtheprevalencewithdifferentdurationofdiabetesandalsoabetterunderstandingoftheriskfactorsassociatedwithDR.

简介：目的探讨白内障超声乳化摘除及人工晶体植入联合房角分离术治疗闭角型青光眼合并白内障的临床效果方法回顾性分析2009年10月至2011年6月我院收治的闭角型青光眼合并白内障共112例（120眼）,应用白内障超声乳化摘除及人工晶体植入联合房角分离术,对房角关闭区域用粘弹剂和手指按压进行钝性分离。观察手术前后的房角及前房变化、视力、眼压及并发症情况,随访6月。结果均经统计学处理。结果120眼手术顺利,术后追踪6月,全部患者术后视力提高,房角开放,中央前房加深,眼压控制良好,手术前后比较差异具有统计学意义。结论超声乳化白内障摘除联合房角分离术是治疗闭角型青光眼合并白内障的有效方法之一,但具体适应证尚待进一步探讨。

简介：AIM:Tostudytheimpactofscleralflapposition,underwhichtheposteriorchamberintraocularlenses(PC-IOL)weresulcus-fixedbytrans-scleralsuture,oncorneaastigmatism.METHODS:Twenty-sixaphakicorcataracteyeswerecomprisedinthisprospectivenoncomparativecaseseriesstudy.Eleveneyeshadtraumaticcataractremovedwithoutsufficientcapsularsupport,3hadblunttraumawithsubluxatedtraumaticcataract,8hadundergonevitreoretinalsurgeryand4hadcongenitalcataractremoved.Theaverageagewas54years(range21-74years),with17menand7women.ThefoldablePC-IOLwasfixedinsulcusbytrans-scleralsuture.TheincisionforIOLimplantationwasmade1mmposteriortolimbusalongthesteepestmeridianofcornea,whilescleralflapstoburytheknotsoftrans-scleralsutureweremadealongtheflattestmeridian.Allthesurgerieswereperformedbyasingledoctor(MaL),andthefollowupwasatleast13months(range13-28months).Thepreoperative,3monthsand1yearpostoperativecornealcurvaturealongthesteepestandflattestcorneameridianandoverallcorneaastigmatismwerecompared.RESULTS:Thecurvaturealongthesteepestmeridianchangedfrom44.25±2.22Dpreoperativelyto44.08±2.16Dat3monthspostoperatively,and43.65±5.23Dat1yearpostoperatively(P>0.05);thecurvaturealongtheflattestmeridianchangedfrom41.24±2.21Dpreoperativelyto43.15±3.94Dat3monthspostoperatively,and42.85±5.17Dat1yearpostoperatively(P<0.05);andthesurgeryinducedastigmatism(SIA)oncorneawascalculatedbyvectoranalysis,whichwas2.42±2.13Dat3monthspostoperatively,and2.18±3.42Dat1yearpostoperatively,thedifferencewasstatisticallysignificant(P<0.05).CONCLUSION:Thescleralflapmadealongtheflattestmeridian,underwhichtheposteriorchamberintraocularlenses(PCIOL)weresulcus-fixedbytrans-scleralsuture,cansteepenthecorneainvaryingdegrees,thusreducingpreexistingcornealastigmatism.