简介：Objective:Tostudytheanti-inflammatoryactivityandtissuedistributionpatternsofintravenousemulsionofdexamethasoneacetateinmice.Methods:Theanti-inflammatorysolutionforinjectionandLimethasone(Jepaneseproduct)givenintravenouslywereevaluatedbyusingthepreformedcarrageenangranulomapouchmethodinrats.Results:Theanti-inflammatoryactivityofdexamethasoneacetateemulsionatlowdoseof0.05mg.kg1wasaspotentasdexamethasonesodiumphosphatesolutionathighdoseof0.3mg.kg1.Thedistributionpatternsinmicetissuesof[^3H]dexamethasoneacetateemulsionand[^3H]dexamethasonesodiumphosphatesolutioninmiceweremarkedlydifferent.Dexamethasoneacetateemulsionshowedamuchhigherconcentrationintheliver,spleen,lung,andinflamedtissues,whereasdexamethasonesodiumphosphatehadahighconcenti,moninthemusclesofvastuslateralis.Theseresultsmayindicatethatdexamethasoneincoporatedinlipidemulsionwastakenupbythereticuloendothelialsystemandinflammatorycellsmuchmorethandexamethasonesodiumphosphatesolution.Conclusion:Whendexamethasoneacetatewasincorporatedinemulsion,thedistributionpatternsintissueswerechangedandtheyhadastrongeranti-inflammatoryactivity.

简介：【摘要】目的：观察哮喘患儿联合应用布地奈德、孟鲁司特钠治疗的临床效果。方法：于2021年05月--2022年05月就诊于本院儿科的哮喘患儿118例作为探讨对象，根据随机分组原则设为研究组（布地奈德+孟鲁司特钠）、常规组（布地奈德），各59例。结果：研究组用药疗效较常规组更高（p