简介：Notopterygiumincisum(QH)hasbeenusedforthetreatmentofrheumatoidarthritis(RA),andvolatileoilsmaybeitsmainlybioactiveconstituents.ThepresentstudywasdesignedtoanalyzethevolatilecompoundsinQHandtodeterminetheanti-arthriticcapacityofNotopterygiumvolatileoilsandthepotentialmechanismofaction.ThevolatilecompoundsanalysiswasconductedbyGC-MS.Theanti-arthriticcapacitytestofthevolatileoilswasconductedonadjuvant-inducedarthritis(AIA)rats.Theanti-inflammatorypropertywastestedinNOreleasemodelinRAW264.7cells.Endothelialcellswereusedtoevaluatetheanti-proliferativeandanti-tubeformativeeffects.70compoundswereanalyzedbyGC-MSinthevolatileoils.NotopterygiumvolatileoilsweakenedtheratAIAinadose-dependentmanner(2,4,and8gcrudedrug/kg).TheNOproductionbyRAW264.7wasdecreasedbymorethan50%inNotopterygiumvolatileoils(5,15,and45μg·mL-1)pretreatedgroups.NotopterygiumvolatileoilsalsoinhibitedEAhy926cellproliferationandfurtherdelayedEAhy926cellcapillarytubeformationinaconcentration-dependentmanner.Theanti-NOproductive,anti-proliferative,andanti-tubeformativeeffectsofNotopterygiumvolatileoilsstronglysuggestedthatthetherapeuticeffectofQHinAIAmightberelatedtothepotentanti-inflammatoryandanti-angiogeniccapacitiesofthevolatileoils.

简介：Colorectalcancer(CRC)isthethirdmostcommoncancerinmenandthesecondmostcommoncancerinwomen,worldwide.Intheearlystagesofthedisease,biomarkerspredictingearlyrelapsewouldimprovesurvivalrates.Inmetastaticpatients,theuseofpredictivebiomarkerscouldpotentiallyresultinmorepersonalizedtreatmentsandbetteroutcomes.TheCXCfamilyofchemokines(CXCL1to17)aresmall(8to10kDa)secretedproteinsthatattractneutrophilsandlymphocytes.Thesechemokinessignalthroughchemokinereceptors(CXCR)1to8.Severalstudieshavereportedthatthesechemokinesandreceptorshavearoleineitherthepromotionorinhibitionofcancer,dependingontheircapacitytosuppressorstimulatetheactionoftheimmunesystem,respectively.Ingeneralterms,activationoftheCXCR1/CXCR2pathwayortheCXCR4/CXCR7pathwayisassociatedwithtumoraggressivenessandpoorprognosis;therefore,thespecificinhibitionofthesereceptorsisapossibletherapeuticstrategy.Ontheotherhand,thelesserknownCXCR3andCXCR5axesaregenerallyconsideredtobetumorsuppressorsignalingpathways,andtheirstimulationhasbeensuggestedasawaytofightcancer.Thesepathwayshavebeenstudiedintumortissues(usingimmunohistochemistryormeasuringmRNAlevels)orserum[usingenzyme-linkedimmunosorbentassay(ELISA)ormultiplexingtechniques],amongothersampletypes.CommonvariantsingenesencodingfortheCXCchemokineshavealsobeeninvestigatedaspossiblebiomarkersofthedisease.ThisreviewsummarizesthemostrecentfindingsontheroleofCXCchemokinesandtheirreceptorsinCRCanddiscussestheirpossiblevalueasprognosticorpredictivebiomarkersaswellasthepossibilityoftargetingthemasatherapeuticstrategy.

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简介：作为一个内部应用的反煽动性的代理人，Escin广泛地在从损伤或操作导致诊所的发炎和浮肿的治疗被使用了。然而，它皮肤的发炎和浮肿上的外部使用的效果仍然保持未经勘探。在现在的学习，反煽动性并且escin的外部使用的anti-edematous效果在老鼠，在老鼠胀大的导致paraxylene的耳朵，和棉花在导致carrageenan的爪浮肿和导致组织安的毛状的渗透被学习在老鼠的导致小团的granuloma。前列腺素E2(PGE2)上的escin胶化的外部使用的效果，肿瘤坏死因素--(TNF-)，并且interleukin-1(IL-1)被ELISA决定。反煽动性的机制被与西方的弄污和实时PCR分析检测glucocorticoid受体(GR)的表示探索，与原子factor-B(NF-B)的进一步的探索，p38激活mitogen的蛋白质kinase(P38MAPK)和使活跃之物protein-1(AP-1)表情。我们证明escin的外部使用证明在不同动物模型的尖锐、长期的发炎上的重要反煽动性的效果和它的反煽动性的效果可能与PGE2，TNF-，和IL-1的下面规定有关。结果也证明escin由支持GR的表示施加了它的反煽动性的效果，与是的可能的机制象NF-B和AP-1那样的GR相关的发信号的分子的表情的抑制。

简介：AIMTo评估热门non-steroidal的预防管理的功效在糖尿病的病人的有斑点的浮肿追随者奔流外科上的反煽动性的药(NSAID)，并且在NSAID的类型之间比较(ketorolactromethamine0.4%并且nepafenac0.1%).METHODSGroup(控制)1作为一个安慰剂组接待了人工的眼泪代用品，(nepafenac)组2收到了热门nepafenac(ketorolac)0.1%，和组3收到了热门ketorolactromethamine0.4%。病人们在完成一个以后手术后地被检查为评估似胞的有斑点的浮肿(CME)的星期，一个月，二个月和三月间隔开发。主要学习结果在与光连贯地形学(10月)测量的中央有斑点的厚度(CMT)正在完成最好改正的视觉尖酸(BCVA)和变化76个病人的.RESULTSEighty眼睛在这研究被包括。BCVA在第三个月显示出统计上重要的差别手术后列在后面在上面在控制组和NSAID组(P=0.04)之间。在开始从的所有情况中的CMT有增加手术后第一个星期直到第三个月。CMT显示出控制组和NSAID组之间的统计上重要的差别从手术后第一个月直到第三个月(P=0.008，0.027，0.004)。在BCVA和外科手术前的10月CMT.CONCLUSIONProphylacticnepafenac和ketorolac组之间没有统计上重要的差别，手术后的NSAID可以在在跟随奔流外科的糖尿病的眼睛减少CME的频率和严厉有一个角色。

简介：Cisplatinandotherplatinum-baseddrugsareusedfrequentlyfortreatmentoflungcancer.However,theirclinicalperformanceareusuallylimitedbydrugresistanceortoxiceffects.Carnosicacid,apolyphenolicditerpeneisolatedfromRosemary(Rosemarinusofficinalis),hasbeenreportedtohaveseveralpharmacologicalandbiologicalactivities.Inthepresentstudy,thecombinationeffectofcisplatinpluscarnosicacidonmouseLLC(Lewislungcancer)xenograftsandpossibleunderlyingmechanismofactionwereexamined.LLC-bearingmiceweretreatedwithintraperitonealinjectionwithcisplatin,oralgavagewithcarnosicacid,orcombinationwithcisplatinandcarnosicacid,respectively.Combinationofcarnosicacidandcisplatinyieldedsignificantlybetteranti-growthandpro-apoptoticeffectsonLLCxenograftsthandrugsalone.MechanisticstudyshowedthatcarnosicacidtreatmentboostedthefunctionofCD8~+TcellsasevidencedbyhigherIFN-γsecretionandhigherexpressionofFasL,perforinaswellasgranzymeB.Inthemeantime,theproportionofMDSC(myeloid-derivedsuppressorcells)intumortissueswerereducedbycarnosicacidtreatmentandthemRNAlevelsofiNOS2,Arg-1,andMMP9,whicharethefunctionalmarkersforMDSC,werereduced.Inconclusion,ourstudyprovedthatthefunctionalsuppressionofMDSCbycarnosicacidpromotedthelethalityofCD8~+Tcells,whichcontributedtotheenhancementofanti-lungcancereffectofcisplatin.

简介：AIMTo评估联合反脉管的endothelial生长的功效和安全因素(VEGF)代理人，口头的glucocorticoid，和为有斑点的浮肿的激光光致疑结治疗(我)对.METHODSThis学习包括了的网膜的静脉吸藏(RVO)第二等16个病人与的16只眼睛联系RVO我。病人们开始与口头的泼尼松和一个intravitrealanti-VEGF代理人被对待。二个星期以后，病人们经历了标准激光光致疑结。改正最好的视觉尖酸(BCVA)，中央网膜的厚度(CRT)，和网膜的容器氧化在收到的12mo.RESULTSPatients上被检验1.43

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