简介：Alpiniapurpurata的目的Ethylacetate摘录在vitro抗氧化剂和anticancer活动为它的潜力被评估。抗氧化剂活动被1评估的方法，1-diphenyl-2-picrylhydrazyl(DPPH)免费激进的清除方法，氢氧根基活动，superoxide基清除活动，氮的氧化物基清除活动，氢过氧化物基清除活动和减少的力量活动。OAW42房间的生存能力被MTT试金评估。结果A。purpurata与一种集中依赖者方式展出了潜在的抗氧化剂活动。摘录与130.20g的IC50在第48小时显示出潜在的anticancer活动?潴??祥獥吗？

简介：

简介：BackgroundTheco-administrationofdexrazoxane(DEX)witheachdoseofdoxorubicin(Dox)isanefficientstrategytorelieveDox-inducedcardiotoxicity,however,themechanismsunderlyingthecardioprotectiveeffectofDEXhavenotbeenwellelucidated.MicroRNAs(miRNAs)areendogenous,smallnon-codingRNAsthatnegativelyregulategeneexpressionindiversebiologicalandpathologicalprocesses.TheaimofthepresentstudywastoinvestigatewhetherthecertaincardiacmiRNAswereinvolvedinDOX-inducedcardiotoxicity.MethodsMaleSDratswererandomizedintofivegroups,includingthe4-week(cumulativedose16mg/kg)andthe8-week(cumulativedose32mg/kg)Dox-treatedgroups,andthecorresponding4-weekand8-weekDoxplusDEX-treatedgroupsandthenormalcontrolgroup.Heartfunctionsoftheanimalsweredetectedbyechocardiography.Quantitativereal-timePCRwasusedtodeterminetheexpressionofcardiacremodeling,apoptosis-relatedgenesandmaturemicoRNAsofinterest.ResultsTheechocardiographydetectionshowedthatcardiacremodelingandimpairedheartfunctionwereobservedafter4-weekand8-weekDoxtreatment,andthecardiacremodelinganddecreasedejectionfraction(EF%)andfractionalshortening(FS%)wereefficientlyrescuedinthecorresponding4-weekand8-weekDoxplusDEX-treatedgroups.ThemyocardialexpressionofAnpandCTGFmRNAwassignificantlyupregulatedbyDoxtreatment,buttheupregulationofAnpandCTGFmRNAwasblockedintheDoxplusDEX-treatedgroups.IGF-1mRNAwassignificantlyup-regulatedinratmyocardiuminDoxplusDEX-treatedgroups,withnosignificantchangesofBcl-2andBAXmRNAexpression.MaturemiRNAsdeterminationdemonstratedthatthemyocardialmiR-1and-30eweresignificantlydownregulatedandmiR-21and-208bweresignificantlyup-regulatedinDoxtreatmentgroups,buttheabovemiRNAdysregulationcouldbeefficientlyreversedafterDEXtreatment.ConclusionsDEXcouldtunethemicroRNAsdysregulationinDox-treatedratmyocardium,miRNAsparticipatedinthecardioprotec

简介：Pleurotussajorcaju(P。sajorcaju)，一朵可食、无毒的蘑菇，作为抗氧化剂被评估，antitumor，反煽动性并且antihypertensive活动。P。sajorcaju是糖类，饮食的纤维，必要氨基酸，矿物质，维生素B，folic酸和类固醇的好来源。反煽动性，immunomodulatory和止痛活动水并且P的菌丝体的methanolic摘录。sajorcaju被调查(数据没被显示出)。这发现建议那P提取。sajorcaju能对煽动性、自体免疫的疾病被使用。那么，P。为它的antiarthritic活动检验的sajorcaju。植物与水和甲醇镇定、独立提取。为antiarthritic活动500和1000mg