简介：【病例】刘阿姨今年53岁,吃东西时＂嗓子眼＂疼了5年。开始时服用药物可以控制症状,但近两年疼痛有加重趋势,范围不仅局限在咽部,还会带着舌根、耳朵里面疼痛,每次疼痛持续约1分钟,像刀子割一样,吃饭或喝水时都有可能诱发疼痛,给生活带来了巨大的困扰,

简介：长期不和:一种怀恨,通常是长期的争吵或者敌对,特别是在两个家庭或者家族之间。这就是字典对于长期不和的解释。在摔角界,到处都是不和留下的气味,这些片断,是绝对不能在摔角史上抹去的。

简介：你不可能没有它们忘掉那些繁琐无趣的讲解,这里有10种完美的补剂可以改变你的训练,你的健康和你的身体"哪些补剂我们应该写在下面呢?"这可能也是读者比较感兴趣的问题。对于《健美先生》的编辑来说,就好像你再问英语老师四级考试如何通过一样。当然,答案是要看你的目标是什么了。但是我们认为绝大多数的读者是想让自己有一个非常不错的体型,所以依据这个目标我们编辑的这个前10名的补剂清单,它包含了所有的训练领域。什么也不说了,好好看吧。

简介：BACKGROUND:Gliomaisthemostcommonintracranialtumorandhasapoorpatientprognosis.Thepresenceofbraintumorstemcellswasgraduallybeingunderstoodandrecognized,whichmightbebeneficialforthetreatmentofglioma.OBJECTIVE:Tousebibliometricindexestotrackstudyfocusesongliomastemcell,andtoinvestigatetherelationshipsamonggeographicorigin,impactfactors,andhighlycitedarticlesindexedinWebofScience.METHODS:AlistofcitationclassicsforgliomastemcellswasgeneratedbysearchingthedatabaseofWebofScience-Expandedusingtheterms"gliomastemcell"or"glioma,stemcell’"or"braintumorstemcell".Thetop63citedresearcharticleswhichwerecitedmorethan100timeswereretrievedbyreadingtheabstractorfulltextifneeded.Eacheligiblearticlewasreviewedforbasicinformationonsubjectcategories,countryoforigin,journals,authors,andsourceofjournals.Inclusivecriteria:(1)articlesinthefieldofgliomastemcellswhichwascitedmorethan100times;(2)fundamentalresearchonhumansoranimals,clinicaltrialsandcasereports;(3)researcharticle;(4)yearofpublication:1899-2012;and(5)citationdatabase:ScienceCitationIndex-Expanded.Exclusivecriteria:(1)articlesneedingtobemanuallysearchedoraccessedonlybytelephone;(2)unpublishedarticles;and(3)reviews,conferenceproceedings,aswellascorrectedpapers.RESULTS:Of2040articlespublished,the63top-citedarticleswerepublishedbetween1992and2010.Thenumberofcitationsrangedfrom100to1754,withameanof280citationsperarticle.Thesecitationclassicscamefromnineteencountries,ofwhich46articlescamefromtheUnitedStates.DukeUniversityandUniversityofCalifornia,SanFranciscoledthelistofclassicswithsevenpaperseach.The63top-citedarticleswerepublishedin28journals,predominantlyCancerResearchandCancerCell,followedbyCellStemCellandNature.CONCLUSION:Ourbibliometricanalysisprovidesahistoricalpersp

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简介：随着现代医学对止血和血栓形成机制认识的不断深入。临床实验室开展有关的检测项目逐渐增多,对凝血仪的要求也越来越高。ACL—TOP全自动凝血分析仪是InstrumentLaboratory公司一款较为成熟的凝血分析仪,其集凝固（浊度）法、发色（吸光度）法和免疫法检测于一身,精密度、线性度及准确度均较稳定,是代表当前全自动凝血检测技术的主流产品。

简介：立春过后,春天的脚步已经渐渐接近。气候日渐转暖,不少人出现了困倦、疲乏、急躁、皮肤干燥等症状,你以为是春困吗？其实这些现象都是在提醒你的内分泌失调了。人体的内分泌系统就像个总指挥,与神经系统搭档一起调节激素的分泌,维持机体内环境的稳定,对于人和生命而言都非常重要。内分泌系统是个大家族,既有我们熟知的甲状腺、胰腺、性腺,也有＂名气稍小＂的甲状旁腺、肾上腺、垂体、松果体等。如果腺体分泌异常,就会导致激素失衡,进而出现多种症状。

简介：生病吃药,除疗效外,你是否关注＂副作用＂？买药时,如果药盒上有下面这样10个字,请一定咨询医师后再购买。麻：高血压患者不宜用感冒药一般除了商品名外,还有根据成分起的通用名,如＂美扑伪麻片＂,从名字就能看出其中的主要成分。＂麻＂指的是含有伪麻黄碱,它有助于减轻感冒、过敏性鼻炎及鼻窦炎引起的鼻充血症状。

简介：口角炎俗称＂烂嘴角＂,在冬季尤其多发,为避免宝宝出现这种情况,家长们要掌握一些妙招,进行有效预防,让宝宝健康度冬季。宝宝烂嘴角,在医学上称之为＂口角炎＂,可发生在单侧或双侧口角,起初时口角黏膜皮肤交界处发白或苍白,随之病变区糜烂变软,张口时有刺痛感,进而出现溃疡、干裂、出血等症状,常有继发感染,有时还会出现小脓包和结痂,说话、吃饭时张不开嘴。如果细菌侵入,可能会导致更严重的口腔问题。

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简介：GDF-5是骨形态发生蛋白家族中较新的成员,在促进肢体发育,调节细胞分化,骨与软骨发育等方面具有重要的作用。本文从其对肢体发育、软骨、骨等的影响方面进行综述。

简介：多多喝水夏季心烦、脾胃停滞，容易造成胃肠不消化、胀气、食欲不振等，从现在起应避免肥腻食物，改由新鲜、清淡饮食取代。乳制食物、过多盐分的食物和油炸食物，或是进补的羊肉炉、麻油鸡、烧酒鸡等，不适合在夏天食用。对老人及小孩，不易消化的糯米也要适可而止。

简介：谈到哮喘，人们似乎对它并不陌生。著名歌星邓丽君就是被哮喘夺去了生命。这是一种呼吸道的慢性炎症性疾病，属于常见病、多发病。目前，我国至少有2000万以上的哮喘患者，但其中只有不足5％的人接受了规范化的治疗。

简介：宝宝饮食太重要，科学喂养要记牢。”哪些食物该吃，哪些食物不宜多吃，对宝宝的健康成长十分重要。

简介：摘要家庭内部56天内多人毒鼠强中毒较少见。该文报道5例患者因误服人为毒鼠强蓄意投毒食物引起毒鼠强中毒，主要临床表现为头痛，头晕、乏力、恶心、呕吐、四肢阵发性强直性抽搐、昏迷、呼吸衰竭，发作时全身抽搐、口吐白沫、小便失禁、意识丧失，实验室检查毒鼠强阳性，结合患者的临床表现以及特异性实验室检查，排除其他疾病，毒鼠强中毒诊断成立。本组病例因服毒病史不明确而误诊3例，误诊率高。本文所提5例患者3例死于呼吸衰竭，2例临床治愈。应提请广大临床医生注意人为投毒引起的毒鼠强中毒因病史不清，发病急，特别容易引起患者死亡，要及时确诊、早期洗胃、有效地控制惊厥及二巯基丙磺酸钠的应用。

简介：AbstractBackground:Epithelial to mesenchymal transition (EMT) is a key process in determining distant metastasis and intra-hepatic dissemination of hepatocellular carcinoma (HCC). Follistatin (FST) family members are considered to be an attractive therapeutic targets and prognostic indicators in cancers. As a derivative of FST, Follistatin Like 5 (FSTL5) may play a similar role in HCC cells. This study aimed to investigate the expression and function of FSTL5 in HCC and its role in EMT.Methods:FSTL5, E-cadherin and vimentin in HCC, and paracancerous tissues were detected by immunohistochemistry. Correlation of FSTL5 expression with overall survival was assessed. The proliferation and invasion of HCC cell lines SK-Hep1 and MHCC-LM3 were analyzed by cell counting kit-8 and Transwell assays. The expression of FSTL5, E-cadherin, and vimentin in HCC cells was examined by polymerase chain reaction and Western blot analysis. T-test was used to analyze the difference in proliferation and invasion ability between groups. The Spearman rank correlation test was used to detect the correlation between the expression of FSTL5 and E-cadherin or vimentin.Results:The expression of FSTL5 in HCC was lower than that in paracancerous tissues (9.97% vs. 82.55%, χ2 = 340.15, P < 0.001). Patients with high FSTL5 expression had a better prognosis (χ2= 8.22, P= 0.004) and smaller tumor diameter (χ2 = 45.52, P < 0.001), less lymph node metastasis (χ2 = 5.58, P= 0.02), earlier tumor node metastasis stage (χ2 = 11.29, P= 0.001), a reduced number of tumors (χ2 = 5.05, P= 0.02), lower alpha-fetoprotein value (χ2 = 24.36, P < 0.001), more probability of hepatitis carrying (χ2 = 40.9, P < 0.001), and better liver function grade (χ2 = 5.21, P = 0.02). Immunohistochemistry showed that FSTL5 expression in HCC tissues was positively correlated with E-cadherin expression (r = 0.38, P < 0.001) and negatively correlated with vimentin expression (r = -0.385, P < 0.001). Furthermore, over-expression of FSTL5 up-regulated the expression of E-cadherin and down-regulated the expression of vimentin in SK-Hep1 (negative control [NC] vs. FSTL5-interfering group [Lv-FSTL5]: E-cadherin [t= 45.03, P < 0.001], vimentin [t= 67, P < 0.001]) and MHCC-LM3 (NC vs. Lv-FSTL5: E-cadherin [t = 50, P < 0.001], vimentin [t = 72.75, P < 0.001]) cells at mRNA level. The same as protein level. In addition, the over-expression of FSTL5 inhibited the proliferation (NC vs. Lv-FSTL5: SK-Hep1, 3 d [t = 7.324, P = 0.018], 4 d [t = 6.23, P = 0.021], 5 d [t= 10.21, P= 0.003]; MHCC-LM3, 3 d [t= 4.32, P= 0.037], 4 d [t= 7.49, P= 0.012], 5 d [t= 9.3661, P = 0.009]) and invasion (NC vs. Lv-FSTL5: SK-Hep1, t= 21.57, P < 0.001; MHCC-LM3, t= 18.04, P < 0.001) of HCC cells.Conclusions:Down-regulation of FSTL5 may contribute to EMT of HCC, and FSTL5 is a potential target in the treatment of HCC.

简介：摘要《过敏与临床免疫学杂志》（Journal of Allergy and Clinical Immunology，JACI）创刊于1929年，是过敏性疾病领域引用率最高的杂志，其发表变应性鼻炎、慢性鼻窦炎和哮喘等临床、基础和转化研究的高质量论文，为变态反应科和呼吸科等研究人员提供了最新前沿动态。本文通过引文分析明确JACI创刊90年来的排名前100（TOP 100）文章，以及它们对过敏与临床免疫领域作出的贡献，旨在为研究者提供未来研究的重点和方向。

简介：一到夏天,宝宝就爱起痱子,脑门儿、脖子、大腿根都是重灾区,这可怎么办?有没有什么防范的办法呢?痱子怎么长出来的宝宝长痱子最主要的原因是热着了。在炎热潮湿的季节,人体要排出大量汗液。当汗液不能迅速蒸发时,过多的汗液就会堵塞汗孔或汗腺导管,而堵塞的下方仍不断分泌的汗液便潴留于皮内,于是形成了痱子。而对于婴幼儿来说,