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简介：AbstractMucormycosis is a lethal human disease caused by fungi of the order Mucorales. Mucormycosis is caused by fungi mainly belonging to the genera Mucor, Rhizopus, and Lichtheimia, all of which belong to the order Mucorales. The number of individuals with mucormycosis-causing disorders has increased in recent years, hence, leading to the spread of mucormycosis. Throughout the coronavirus disease 2019 (COVID-19) pandemic, numerous cases of mucormycosis in COVID-19-infected patients have been reported worldwide, and the illness is now recognized as COVID-19-associated mucormycosis, with most of the cases being reported from India. Immunocompromised patients such as those with bone marrow sickness and uncontrolled diabetes are at a greater risk of developing mucormycosis. Genes, pathways, and other mechanisms have been studied in Mucorales, demonstrating a direct link between virulence and prospective therapeutic and diagnostic targets. This review discusses several proteins such as high-affinity iron permease (FTR1), calcineurin, spore coat protein (CotH), and ADP-ribosylation factors involved in the pathogenesis of mucormycosis that might prove to be viable target(s) for the development of novel diagnostic and therapeutic methods.

简介：摘要：智能制造是我国由制造大国迈向制造强国的战略途径，涉及的技术较为复杂，但MES无疑是核心之一。智能制造的“智”是体现在紧耦合MES中，即系统具备一定的判断和决策能力。紧耦合MES落地较难，本文结合多个智能工厂成功落地经验给出一些路径，希望能为行业发展起到抛砖引玉之作用。

简介：摘要：焚烧法是实现我国污泥快速减量化、无害化处置的主流方式，而在“双碳”目标的推动下，燃煤耦合污泥焚烧发电技术能有效实现燃煤领域低碳减排和污泥清洁焚烧处置，本文对比了不同技术路线的优缺点并进行深入分析，当污泥掺烧比例控制在一定范围时，既可以实现污泥的无害化处置，又能保证机组维持运行的经济性和清洁性。

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简介：摘要：约翰·冈田的小说《不一不仔》反映了1942年的重置营事件和1943年的征兵令对战后日裔美国社区造成的灾难性后果。本论文从后殖民主义批评理论的视角，以理论中的“他者”为切入点，从家庭和社会两个层面分析了《不-不仔》一书中“不不仔”的“他者”身份。

简介：摘要：随着生产装置的大型化，装置中的构筑物尺寸也随之增大、增高。风荷载作为水平荷载的重要性尤为突出。风荷载中的风振系数对风荷载大小的影响相对较大，从风振系数的计算公式中可以分析出，结构的基本自振周期影响风振系数。本文通过不同的结构模型，探讨风振系数与结构基本自振周期的关系。

简介：摘要：在自然科学、工程技术中，许多实际问题可以归结为二阶常微分方程，因此求二阶常微分方程的解有着非常重要意义。本文介绍利用待定系数法法求解二阶常系数非齐次线性常微分方程。

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简介：摘要：专用平板附着系数测试装置是对平板式制动检验台附着系数检测的专用计量器具。针对平板附着系数的检测有便于携带，操作简便，测试结果科学准确的特点。本文对专用平板附着系数测试装置的制作原理进行了简单的阐述，并对附着系数的不确定度进行了分析。

简介：摘要：在焦炉当中，热工系数的高低与炼焦能耗、焦炭质量等相关指标密切相关，怎样促进热工系数的显著提高，是确保焦虑热工管理效率的重要内容。本文通过对焦炉热工管理的现状进行分析，明确其管理的突破点，通过结合热工系数偏低的原因，从而对提高焦炉热工系数的方法进行阐述。

简介：摘要：利用 ABAQUS 软件对边坡进行模拟，运用强度折减法，分析抗滑桩不同桩长、桩位、桩径及桩土模量比对边坡安全系数的影响。实例计算结果表明：满足抗滑桩平面布置要求时，桩长越长，对边坡抗滑作用越好；将抗滑桩设置于边坡底部比设置在边坡中部或坡顶抗滑效果好；增大桩径可以非常有效的增加边坡的安全系数；安全系数随抗滑桩的弹性模量增加成线性增加趋势。

简介：摘要：在焦炉当中，热工系数的高低与炼焦能耗、焦炭质量等相关指标密切相关，怎样促进热工系数的显著提高，是确保焦虑热工管理效率的重要内容。本文通过对焦炉热工管理的现状进行分析，明确其管理的突破点，通过结合热工系数偏低的原因，从而对提高焦炉热工系数的方法进行阐述。

简介：摘要：在焦炉当中，热工系数的高低与炼焦能耗、焦炭质量等相关指标密切相关，怎样促进热工系数的显著提高，是确保焦虑热工管理效率的重要内容。本文通过对焦炉热工管理的现状进行分析，明确其管理的突破点，通过结合热工系数偏低的原因，从而对提高焦炉热工系数的方法进行阐述。

简介：摘要：作为电梯建筑的重要运输设备，承运人和货物承担着重要的上下楼梯任务，因此电梯运行的安全性和稳定性越来越受到人们的关注。人们日常使用的电梯主要由牵引驱动电梯、自动扶梯和自动人行道组成，平衡系数是电梯牵引驱动的重要参数之一。牵引电梯平衡系数太小，导致电梯牵引力下降、能耗增加、电梯制动困难、电梯舒适度下降等问题。

简介：摘要：当前的配电网负荷需要系数选取，主要依赖于规划人员经验值取值，容易导致计算误差大。为提升需要系数预测的精度，提出一种基于数据挖掘的负荷需要系数预测方法。该方法首先采用K-means聚类分析对用户类型进行聚类，在聚类结果基础上，建立多层双向循环神经网络模型，实现对负荷需要系数预测模型的训练和预测。案例分析结果表明，采用所提的预测方法能有效提高需要系数取值的准确性，提高规划效益。

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简介：AbstractIn order to effectively implement the Tianjin Biosecurity Guidelines for Codes of Conduct for Scientists, biosecurity awareness-raising and education are essential because if these are not in place scientists will not understand the need for biosecurity codes of conduct. In an effort to assist in the implementation of the guidelines, a small-scale survey was carried out in early 2022 of biosecurity awareness-raising and education projects that have been developed over the last two decades to discover what resources and experience have been accumulated. It is argued that the survey demonstrates that much of what is needed to implement the guidelines effectively has been developed, but that there are specific deficiencies that need to be remedied quickly. In particular, an updated teaching resource covering the core issues related to the Biological and Toxin Weapons Convention (BTWC) and the problem of dual use in scientific research needs to be made widely available and translated into at least the six official United Nations (UN) languages. Additionally, more specialists from the Humanities with expertise in ethics need to become involved in biosecurity awareness-raising and education activities. While advantage should be taken now of the available national, regional and international networks of people involved in related activities, it is suggested that in the longer term cooperation in biosecurity awareness-raising and education will benefit from the development of an equivalent organisation to the International Nuclear Security Education Network (INSEN) organised through the International Atomic Energy Agency (IAEA).