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简介:[摘要] 通过分析需要系数与同时系数的概念,详细介绍其在负荷计算中的取值要求,并以实例阐述给排水工程中通过需要系数与同时系数负荷计算时与传统负荷计算结果的差别及实际意义。
简介:AbstractBackground:The End Tuberculosis (TB) Strategy of the World Health Organization highlights the need for patient-centered care and social protection measures that alleviate the financial hardships faced by many TB patients. In China, TB treatments are paid for by earmarked government funds, social health insurance, medical assistance for the poor, and out-of-pocket payments from patients. As part of Phase III of the China-Gates TB project, this paper introduces multi-source financing of TB treatment in the three provinces of China and analyzes the challenges of moving towards universal coverage and its implications of multi-sectoral engagement for TB care.Main text:The new financing policies for TB treatment in the three provinces include increased reimbursement for TB outpatient care, linkage of TB treatment with local poverty alleviation programs, and use of local government funds to cover some costs to reduce out-of-pocket expenses. However, there are several challenges in reducing the financial burdens faced by TB patients. First, medical costs must be contained by reducing the profit-maximizing behaviors of hospitals. Second, treatment for TB and multi-drug resistant TB (MDR-TB) is only available at county hospitals and city or provincial hospitals, respectively, and these hospitals have low reimbursement rates and high co-payments. Third, many patients with TB and MDR-TB are at the edge of poverty, and therefore ineligible for medical assistance, which targets extremely poor individuals. In addition, the local governments of less developed provinces often face fiscal difficulties, making it challenging to use of local government funds to provide financial support for TB patients. We suggest that stakeholders at multiple sectors should engage in transparent and responsive communications, coordinate policy developments, and integrate resources to improve the integration of social protection schemes.Conclusions:The Chinese government is examining the establishment of multi-source financing for TB treatment by mobilization of funds from the government and social protection schemes. These efforts require strengthening the cooperation of multiple sectors and improving the accountability of different government agencies. All key stakeholders must take concrete actions in the near future to assure significant progress toward the goal of alleviating the financial burden faced by TB and MDR-TB patients.
简介:摘 要: 锅炉引风机在运行过程中节能、工艺操作都需要调速,调速技术飞速发展,磁力耦合以投资较少、稳定可靠、谐波较少、改造简单、抗晃电能力强优点脱颖而出,将磁力耦合应用在锅炉引风机上具有可行性。
简介:AbstractBackground:The global prevalence of nonalcoholic fatty liver disease (NAFLD) is increasing. The pathogenesis of NAFLD is multifaceted, and the underlying mechanisms are elusive. We conducted data mining analysis to gain a better insight into the disease and to identify the hub genes associated with the progression of NAFLD.Methods:The dataset GSE49541, containing the profile of 40 samples representing mild stages of NAFLD and 32 samples representing advanced stages of NAFLD, was acquired from the Gene Expression Omnibus database. Differentially expressed genes (DEGs) were identified using the R programming language. The Database for Annotation, Visualization and Integrated Discovery (DAVID) online tool and Search Tool for the Retrieval of Interacting Genes/Proteins (STRING) database were used to perform the enrichment analysis and construct protein-protein interaction (PPI) networks, respectively. Subsequently, transcription factor networks and key modules were identified. The hub genes were validated in a mice model of high fat diet (HFD)-induced NAFLD and in cultured HepG2 cells by real-time quantitative PCR.Results:Based on the GSE49541 dataset, 57 DEGs were selected and enriched in chemokine activity and cellular component, including the extracellular region. Twelve transcription factors associated with DEGs were indicated from PPI analysis. Upregulated expression of five hub genes (SOX9, CCL20, CXCL1, CD24, and CHST4), which were identified from the dataset, was also observed in the livers of HFD-induced NAFLD mice and in HepG2 cells exposed to palmitic acid or advanced glycation end products.Conclusion:The hub genes SOX9, CCL20, CXCL1, CD24, and CHST4 are involved in the aggravation of NAFLD. Our results offer new insights into the underlying mechanism of NAFLD progression.
简介:摘要:气溶胶设备维护的好坏对确保气溶胶质量浓度数据观测和传输是否正常起着决定性作用,本文结合平罗局气溶胶仪器性能及工作实际,依据大气成分观测业务规范及大气成分质量控制信息采集软件操作手册,归纳出气溶胶散射系数设备使用维护需注意的问题,确保气溶胶散射系数设备正常运转。
简介:摘要:磁耦合谐振式无线电能传输是一种利用线圈间高频耦合谐振磁场实现能量无线传输的新兴技术。目前该技术在传输距离、效率和功率等方面还不能够满足实用化所提出的要求,仍存在一些问题有待于研究。其理论研究主要采用耦合模理论和集中参数电路模型的分析方法,对耦合体的动态过程、系统内部能量分布规律的研究还不够深入。另外由于工作频率高于电力电子器件的一般使用频率,磁耦合线圈的耦合系数较小并且处于谐振状态,存在着功率器件难以满足要求、系统损耗较大、效率较低等问题。本文从机理与模型、谐振线圈组、磁场驱动源、系统设计等方面展开研究,为磁耦合无线电能传输系统的分析与设计奠定了理论基础。
简介:摘要:电感耦合等离子体质谱(ICP-MS)是以电感耦合等离子体为离子源,以质谱分析器进行检测的无机多元素和同位素分析技术。该技术以其灵敏度高、干扰少、检出限低、可测定元素多、线性范围宽、可进行同位素分析、应用范围广等优点被公认为是当前最先进的痕量无机元素分析技术之一。本文重点探讨了电感耦合等离子体质谱技术。
简介:摘要目的探讨舌黏膜耦合颊黏膜与舌黏膜耦合异种脱细胞基质生物膜(ADM)一期尿道成形术治疗男性尿道下裂多次修复失败患者的临床疗效。方法回顾性分析2017年2月至2019年2月收治的26例成年男性尿道下裂修复失败患者的病例资料,其中上海交通大学附属第六人民医院18例,山西医科大学第二医院3例,郑州大学第一附属医院3例,哈尔滨医科大学附属第二医院2例。根据尿道替代材料不同将患者分为两组,A组为舌黏膜耦合颊黏膜组(14例),平均年龄(29.5±1.2)(18~41)岁;既往手术次数平均(3.6±0.7)(2~5)次;既往取口腔黏膜次数平均(1.0±0.5)(0~2)次;尿道缺损长度(6.4±0.6)cm。B组为舌黏膜耦合ADM组(12例),平均年龄(26.5±0.8)(20~38)岁;既往手术次数平均(4.6±0.8)(3~5)次;既往取口腔黏膜次数平均(1.0±0.5)(0~2)次;尿道缺损长度(6.7±0.4)cm。两组上述指标比较差异均无统计学意义(P>0.05)。手术方式:将阴茎伸直,切除纤维组织或瘢痕,测量尿道缺损长度。A组采用舌黏膜铺尿道板,加盖颊黏膜;B组采用舌黏膜铺尿道板,加盖ADM[异种(牛)脱细胞基质敷料,规格5 cm×5 cm]。A组取舌黏膜的长度平均(5.0±0.2)(4.0~6.0)cm,宽度平均(1.2±0.2)(1.0~1.5)cm;取颊黏膜的长度平均(4.1±0.2)(3.5~5.5)cm,宽度平均(1.2±0.2)(1.0~1.5)cm。B组取舌黏膜的长度平均(5.0±0.2)(5.0~6.0)cm,宽度平均(1.2±0.2)(1.0~1.5)cm。两组术中取口腔黏膜长度差异有统计学意义(P<0.05)。尿道下裂修复成功标准:①阴茎外观接近正常;②矫正阴茎下曲;③尿道正位开口;④尿流尿线正常,排尿通畅,成人最大尿流率>15 ml/s。比较两组的疗效和并发症发生率。结果术后平均随访(16.3±1.6)(8~24)个月。A、B组口腔区域并发症发生比例分别为:口腔供区疼痛7/14例和1/12例,张口紧绷感8/14例和1/12例,口腔供区麻木感8/14例和1/12例,差异有统计学意义(P<0.05)。A、B组尿道并发症发生比例分别为:尿道瘘1/14例和4/12例,尿道狭窄2/14例和6/12例,差异有统计学意义(P<0.05);阴茎弯曲2/14例和1/12例,差异无统计学意义(P>0.05)。A、B组手术成功比例分别为12/14例和5/12例,差异有统计学意义(P<0.05)。结论对于尿道下裂多次修复失败后皮源缺少的患者,建议采用舌黏膜耦合颊黏膜一期尿道成形术修复尿道。舌黏膜耦合ADM尽管具有口腔黏膜取材少、术后口腔并发症低等优点,为多次手术失败阴茎局部皮源缺损患者提供了一种新途径,但存在术后并发症多、手术成功率低等风险,应谨慎使用,不推荐一线使用。