简介：AbstractBackground:Hypertension is considered an important risk factor for the coronavirus disease 2019 (COVID-19). The commonly anti-hypertensive drugs are the renin-angiotensin-aldosterone system (RAAS) inhibitors, calcium channel blockers (CCBs), and beta-blockers. The association between commonly used anti-hypertensive medications and the clinical outcome of COVID-19 patients with hypertension has not been well studied.Methods:We conducted a retrospective cohort study that included all patients admitted with COVID-19 to Huo Shen Shan Hospital and Guanggu District of the Maternal and Child Health Hospital of Hubei Province, Wuhan, China. Clinical and laboratory characteristics were extracted from electronic medical records. Hypertension and anti-hypertensive treatment were confirmed by medical history and clinical records. The primary clinical endpoint was all-cause mortality. Secondary endpoints included the rates of patients in common wards transferred to the intensive care unit and hospital stay duration. Logistic regression was used to explore the risk factors associated with mortality and prognosis. Propensity score matching was used to balance the confounders between different anti-hypertensive treatments. Kaplan-Meier curves were used to compare the cumulative recovery rate. Log-rank tests were performed to test for differences in Kaplan-Meier curves between different groups.Results:Among 4569 hospitalized patients with COVID-19, 31.7% (1449/4569) had a history of hypertension. There were significant differences in mortality rates between hypertensive patients with CCBs (7/359) and those without (21/359) (1.95% vs. 5.85%, risk ratio [RR]: 0.32, 95% confidence interval [CI]: 0.13-0.76, χ2 = 7.61, P = 0.0058). After matching for confounders, the mortality rates were similar between the RAAS inhibitor (4/236) and non-RAAS inhibitor (9/236) cohorts (1.69% vs. 3.81%, RR: 0.43, 95% CI: 0.13-1.43, χ2 = 1.98, P = 0.1596). Hypertensive patients with beta-blockers (13/340) showed no statistical difference in mortality compared with those without (11/340) (3.82% vs. 3.24%, RR: 1.19, 95% CI: 0.53-2.69, χ2= 0.17, P= 0.6777).Conclusions:In our study, we did not find any positive or negative effects of RAAS inhibitors or beta-blockers in COVID-19 patients with hypertension, while CCBs could improve prognosis.

简介：Echocardiographyisthemostfrequentlyusedimagingmodalitytodeterminecardiacfunction.Leftventricularejectionfractionthemostwidelyusedparameterforevaluationofsystolicfunction,providesimportantprognosticvalueinclinicalpractice,andformspartoftheevidencebaseformanydecisionsaboutcardiovascularcare.However,ejectionfractionhasseveralsubstantiallimitationsandisinsensitivetosubtlechangesinsystolicfunction.Theassessmentofmyocardialdeformationwithechocardiographyhasbeenstudiedfortwodecades,andisincreasinglyusedintheclinicalsetting.Thistechniquecanpreciselycharacterizethemechanicsofmyocardialcontractionandrelaxation.Themostcommonlyusedparameterisgloballongitudinalstrain,whichismoresensitivethanejectionfractionforthemeasurementofsystolicfunction.Thisreviewfocusesontheprognosticvalueofgloballongitudinalstraininpredictingadverseoutcomesincardiovasculardisease.

简介：Positronemissiontomography(PET)isapowerfulnoninvasiveimagingtoolforphenotypingpatientsatriskoforwithknowncoronaryarterydisease(CAD).Oneofthekeyadvantagesoverotherimagingmodalitiesisitsuniqueabilitytoquantifyphysiologicprocesses,includingmyocardialbloodflow(inmillilitersperminutepergramofmyocardium),metabolism,andcardiacreceptors,anditshighsensitivityfordelineatingandquantifyingmoleculartargetsinvivousingtargetedimagingprobes.CardiacPET/CToffersopportunityforacomprehensivenoninvasiveevaluationoftheconsequencesofatherosclerosisinthecoronaryarteriesandthemyocardium.

简介：AIM:Toevaluatewhetherthelevelofthrombospondin-1(TSP-1)inaqueoushumorcanpredicttheprognosisoftrabeculectomyinpatientswithprimaryangle-closureglaucoma(PACG).METHODS:Thiscase-controlstudyinvolved26patientswithPACGwhoexperiencedafailedtrabeculectomy(casegroup)and78age-andsex-matchedpatientswithPACGwhounderwentsuccessfultrabeculectomy(controlgroup).AqueoushumorwascollectedatthetimeoftrabeculectomyandtestedforTSP-1andTGF-β2levelswithanenzyme-linkedimmunosorbentassaymethod.Logisticregressionmodelingwasusedtoassesstheriskfactorsforfailedtrabeculectomy.RESULTS:ThemeanTSP-1aqueousconcentrationsweresignificantlyhigherinthecasegroup(20.67±9.79ng/mL)thanthecontrolgroup(5.17±2.29ng/mL)(P<0.001).Thetransforminggrowthfactor-β2(TGF-β2)aqueousconcentrationsweresignificantlydifferentbetweenthecaseandcontrolgroup,at3633.25and1090.24pg/mL,respectively(P<0.001).LogisticregressionanalysisrevealedTSP-1levelasanindependentriskfactorforafailedtrabeculectomy(OR=3.540;95%CI=1.092-11.482).CONCLUSION:TheaqueoushumorTSP-1andTGF-β2levelsarehigherinPACGeyeswithfailedtrabeculectomythanwithsuccessfultrabeculectomyatoneyear.TheaqueoushumorTSP-1levelisanindependentriskfactorassociatedwithfailedtrabeculectomy.

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简介：ObjectiveToinvestigatetheeffectoffamilytherapyonprognosisofpatientswithschizophrenis.Method200patientsafterdischargingfromhospitalwererandomlydividedintotwogroups:controlgroup(n=100)andexperimentgroup(n=100).Familytherapywasactualizedinpatientsofexperimentgroup.ResultsTherewassignificantdifferenceinpercentofrecurrenceratebetweencontrolgroup(38%)andexperimentgroup(18%,P<0.05).ConclusionFamilytherapymaydecreaserecurrencerateofschizophrenicafterdischargingfromhospital.

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简介：MurongFeng,a31-year-oldactivistfromHebeiProvinceinnorthernChina,hadattendedseveraltrainingworkshopsfornon-govemmentalorgani-zations(NGOs)relatedtoHIV/AIDSpre-ventionbeforehecametoBeijinglastOctoberforanotherone.Thistime,theleadingmemberofAiZhiGuang(lightoflove)caregroupforhomosexuality-foundthetrainersdiffer-ent.

简介：Thispaperproposesanewwaytoimprovetheperformanceofdependencyparser:subdividingverbsaccordingtotheirgrammaticalfunctionsandintegratingtheinformationofverbsubclassesintolexicalizedparsingmodel.Firstly,theschemeofverbsubdivisionisdescribed.Secondly,amaximumentropymodelispresentedtodistinguishverbsubclasses.Finally,astatisticalparserisdevelopedtoevaluatetheverbsubdivision.Experimentalresultsindicatethattheuseofverbsubclasseshasagoodinfluenceonparsingperformance.

简介：Theyear2001wasoneofgreathistoricalsignificanceforChinainitsreformandopeningup.ChinawasadmittedtotheWTO;itsuccessfullyhostedAPECleaderssummit;anditwonthebidforhostingthe2008SummerOlympics.Thehumanrightsconditionsdevelopedsidebysidewiththedevelopmentofthewholesociety,leavingusadeepimpression.Wehavecollectedagroupofarticles,whichreview,fromdifferentangles,thechangesinthedevelopmentofhumanrightsinthecountry.

简介：Mostofmiddleshoolstudents,Feelitdiffiulttodoreadingcomprehension,Butatthesametimeit’satleast20%ineachtestsoit’sspecialimportantforthestudentstodoitwell.HowtoimproveyourreadingcomprehensionThecommonstepsare!Firstreadthroughthewholetext,makesurethemainidea,themainperson(who),Whathappened(what),howithappened,(how),andwhereithappened,(where)andtheresult,whenyou’rereading,makesuretheprons,eg,it/she/hethey/me/this,whe/whatitdoesreterto,it’sveryimportantforyoutoundertandwholetext.Second,occordtingtothequestions,readthetextonewordbyoneword,payspecialattentiontothosesentencesareconnectwithquestions.Third:readthetextagain,checkanswers.eg,Whatdifferentkindsofbirdscanspeak,Theycancopythesoundsoflanguages,Africanparrotsarethebestknownforthiskindoftalkingbirds.

简介：VanAndelResearchInstitute(VARI)investigatorsworkingincollaborationwithClevelandClinicresearchershavedeterminedthattwotypesofkidneytumorspreviouslythoughttobedifferentdiseasesareactuallyvariationsofthesamedisease.Thisfindingwillhelpdoctorstomoreaccuratelydiagnosethediseaseinpatients,anddemonstratestheimpor-tanceofusingmoleculardatatodiagnosecanceringeneral.

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简介：Principalthesesoffocustectoniesandmetallogenyofactiveregion(unlinearmetallogeny)arecloseinspace-genetieaspectes,ageandparticularyinorecontent(tablel).MetallogcnicanalysisofdataondcpositdistributioninthcfoCus8tructurcs(structurcsofCcntraltypc-SCT)andinthcirconccntriczonc8,conductcdonthebaseofSCTidcaa

简介：ＩＮＳＩＴＵＬＡＢＥＬＩＮＧＡＰＯＰＴＯＳＩＳＩＮＢＲＥＡＳＴＣＡＮＣＥＲＡＳＲＥＬＡＴＥＤＴＯＰＲＯＧＮＯＳＩＳＷｕＪｉｏｎｇ吴炅ＳｈａｏＺｈｉｍｉｎ邵志敏ＪｉａｎｇＭｉｎｇ江明ＨａｎＱｉｘｉａ韩企夏ＺｈａｎｇＴｉｎｇｑｉｕ张廷ＳｈｅｎＺｈｅｎｚ...

简介：目的将在hepatocellular癌(HCC)调查cortactin表示并且在HCC病人的预后探索它的意义。方法Immunohistochemistry被执行让119HCC纸巾(HCC)和paratumorous肝纸巾(PTLT)的石蜡样品计算cortactin表达式。在HCC和PTLT的cortactin表示差别被McNemars测试分析。在HCC和clinicopathologic因素的cortactin表情的关系与Mann-WhitneyU测试被分析。Kaplan-Meier方法和木头等级测试被采用比较在Cortactin否定表示组，弱表示组和强壮的表示组之间的全面幸存。cortactin的表示进一步与西方的弄污在19个新鲜HCC和PTLT标本被决定。结果Cortactin表示率在HCC是显著地更高的(53/119，44.5%)比那在PTLT(2/119，1.7%)(P<0.001)。在HCC的upregulatedcortactin表示显著地被相关到形成(P=0.012)，脉管的侵略(P=0.037)和高Edmondson啤酒杯杯分级的囊的缺席(P=0.020)，并且预言了更短的全面幸存。西方的弄污证明那cortactin表情与相应PTLT相比从19HCC(47.4%)是在9的upregulated。结论Cortactin表示是在HCC的upregulated并且与病人的更短的全面幸存有关，建议cortactin可能起在HCC的转移的作用并且预言HCC病人的差的预后。

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简介：I.ProtectionofHumanRightsoftheConvictedHumanrightsoftheconvictedrefertotherightsenjoyedorduetobeenjoyedbypeoplesubjecttocriminalpunishmentbyvirtueofitsnaturalandsocialattributes.Intermsofnaturalattribute,theconvictedarepeople,despitethefactthattheyhavebeensentencedtocriminalpunishments.Sothey