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  • 简介:APRIL2015ChinaPledgesEducation,Hospital,JurorSystemReformsOnApr.1,China’scentralauthoritiesrolledoutplanstosupportruralteachers,overhaulpublichospitalsandimprovepublicsupervisionofcourtcases.Theplanswereadoptedatthe11thmeetingofthecentralleadinggroupfordeepeningoverallreformonWednesday,duringwhichPresidentXiJinping,whoisalso

  • 标签: DEEPENING authorities SUPERVISION COURT APRIL issued
  • 简介:BeijinghasbeenoneoftheepicentersattackedmostseverelybytheSARS-CoV(severeacuterespiratorysyndrome-associatedcoronavirus)sincethefirstpatientwasdiagnosedinoneofthecity'shospitals.WenowreportcompletegenomesequencesoftheBJGroup,includingfourisolates(IsolatesBJ01,BJ02,BJ03,andBJ04)oftheSARS-CoV.ItisremarkablethatallmembersoftheBJGroupshareacommonhaplotype,consistingofsevenlocithatdifferentiatethegroupfromotherisolatespublishedtodate.Among42substitutionsuniquelyidentifledfromtheBJgroup,32arenon-synonymouschangesattheaminoacidlevel.Rootedphylogenetictrees,proposedonthebasisofhaplotypesandothersequencevariationsofSARS-CoVisolatesfromCanada,USA,Singapore,andChina,gaverisetodifferentparadigmsbutpositionedtheBJGroup,togetherwiththenewlydiscoveredGD01(GD-Ins29)inthesameclade,followedbytheH-UGroup(fromHongKongtoUSA)andtheH-TGroup(fromHongKongtoToronto),leavingtheSPGroup(Singapore)moredistant.ThisresultappearstosuggestapossibletransmissionpathfromGuangdongtoBeijing/HongKong,thentoothercountriesandregions.

  • 标签: SARS 冠状病毒 全基因序列 北京株
  • 简介:TheR(replicase)proteinistheuniquelydefinednon-structuralprotein(NSP)responsibleforRNAreplication,mutationrateorfidelity,regulationoftranscrip-tionincoronavirusesandmanyotherssRNAviruses.Basedonourcompletegenomesequencesoffourisolates(BJ01-BJ04)ofSARS-CoVfromBeijing,China,weanalyzedthestructureandpredictedfunctionsoftheRproteinincomparisonwith13otherisolatesofSARS-CoVand6othercoronaviruses.TheentireORF(open-readingframe)encodesfortwomajorenzymeactivities,RNA-dependentRNApolymerase(RdRp)andproteinaseactivities.TheRpolyproteinunder-goesacomplexproteolyticprocesstoproduce15function-relatedpeptides.Ahydrophobicdomain(HOD)andahydrophilicdomain(HID)arenewlyidentifiedwithinNSP1.ThesubstitutionrateoftheRproteinisclosetotheaverageoftheSARS-CoVgenome.ThefunctionaldomainsinallNSPsoftheRproteingivedifferentphylogeneticresultsthatsuggesttheirdifferentmutationrateunderselectivepressure.ElevenhighlyconservedregionsinRdRpandtwelvecleavagesitesby3CLP(chymotrypsin-likeprotein)havebeenidentifiedaspotentialdrugtargets.Findingssuggestthatitispossibletoobtaininformationaboutthephy-logenyofSARS-CoV,aswellaspotentialtoolsfordrugdesign,genotypinganddiagnosticsofSARS.

  • 标签: SARS 冠状病毒 R蛋白 结构 功能 基因序列
  • 简介:[摘要 ] 本文用 EGS002作为核心器件,设计出了一款以直流电压为 12V的电源的车载逆变模块。主要包含 BOOST升压模块、单极控制逆变模块、辅助电源模块、滤波模块组成,分别介绍了车用逆变电源各模块的原理及其拓扑结构。根据实验测试结果显示,这款车载逆变器,可以将输入的低压直流电转换为电气设备需要的工频交流电输出,一般是 220V、 50Hz的交流电压。本模块设计的转化的效率高达 95%甚至更高,输出电压的波形比较稳定,总谐波失真较小,工作性能牢靠。此外,本次设计的车载逆变模块还能够防止过压、防止过流、防止过热等问题。

  • 标签: 单相逆变 EGS002 车载逆变器 高效率
  • 简介:伴随着精心策划的《珍藏米兰》开始紧锣密鼓地制作,我们的思绪被勾回到了红黑军团上世纪80年代末90年代初的辉煌时代。作为米兰众星中极特殊的一位,伦蒂尼勾起了我的好奇,于是乎动用各种搜索引擎,终于发现,这位昔日的世界第一身价球星尚未退役,他现在效力于意

  • 标签: 效力 出场 赛季 意大利队 小城 红黑
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  • 简介:第一,项目划分,以现行全统定额、行业定额、地方定额为基础,与《建设工程工程量清单计价规范》GB50500-2013(以下简称2013版《清单计价规范》)的章、节顺序相衔接。切实反映新技术、新工艺、新材料、新设备变化情况,调整不合理项目,删除技术淘汰项目,增加建筑节能、环保等项目。

  • 标签: 《建设工程工程量清单计价规范》 定额 装饰工程 房屋建筑 消耗量 解析