简介：二新Steroidal碱，命名pengbeisineA和pengbeisineB，从FritillariamonathaMigo的新鲜灯泡被孤立。与已知的碱一起。结构作为22,26-imino-17被描绘，23-oxido-5-jerv-6-oxo-2,3β-diol并且22，26-imino-17，23-oxido-5-jerv-6-oxo-2β，3-diol根据分光镜的方法。

简介：TheaconitebelongstoplantsofgenusAconituminfamilyofRanunculaceaandhavenotableclinicalfunctionsintreatingrheumaticarthritis,heartfailure,etc.However,accidentsofaconitine(fromaconite)poisoningfrequentlyoccurtomanypeopletakingtheseherbs.

简介：Twonewsteroidalalkaloids,isoconkuressineandN-formylconessimine,togetherwith6knownsteroidalalkaloidsincludingconkuressine,conessine,isoconessimine,conimine,conarrhimine,andfuntudienine,wereisolatedfromtheseedsofHolarrhenaantidysenteriacaWall.exA.DC.Theirintrinsicantibacterialactivitiesandsynergisticeffectswithpenicillinandvancomycinwereanalyzedinmethicillinsensitivestaphylococcusaureus(MSSA)andmethicillinresistantstaphylococcusaureus(MRSA).Twoofthesteroidalalkaloidsincludingonenewcompound(N-formylconessimine)showedpotentialantibacterialactivityandpossessedsynergisticeffectswithpenicillinandvancomycin,respectively.

简介：Ｃ１９－ＤＩＴＥＲＰＥＮＯＩＤＡＬＫＡＬＯＩＤＳＯＦＤＥＬＰＨＩＮＩＵＭＭＯＬＬＩＰＩＬＵＭ￥ＳｕｏＭｉｎｇＺＨＡＮＧ；ＱｉｎｇＹｕＯｕ(ＬａｎｚｈｏｕＩｎｓｔｉｔｕｔｅｏｆＣｈｅｍｉｃａｌＰｈｙｓｉｃｓ，ＣｈｉｎｅｓｅＡｃａｄｅｍｙｏｆＳｃｉ?..

简介：Naturalproductshavegainedpopularityworldwideforpromotinghealthcare,aswellasdiseaseprevention.Alkaloidsareimportantchemicalcompoundsthatserveasarichreservoirfordrugdiscovery.Severalalkaloidsisolatedfromnaturalherbsexhibitantiproliferation,antibacterial,antiviral,insecticidal,andantimetastaticeffectsonvarioustypesofcancersbothinvitroandinvivo.Thispaperfocusesonthenaturally-derivedalkaloidssuchasberberine,matrine,piperine,fritillarine,andrhynchophylline,etc.,andsummarizestheactionmechanismsofthesecompounds.Basedontheinformationintheliteraturethatissummarizedinthispaper,theuseofalkaloidsasdrugsisverypromising,butmoreresearchandclinicaltrialsarenecessarybeforefinalrecommendationsonspecificalkaloidscanbemade.Followingthis,itishopedthatasaresultofthisreview,therewillbeagreaterawarenessoftheexcellentpromisethatnaturalalkaloidsshowforuseinthetherapyofdiseases.

简介：有electrochemiluminescence察觉的新、简单的毛状的电气泳动为分离和一双diastereoisomeric碱(麻黄素和pseudoephedrine)的quantification被开发。察觉的限制(S/N=3)4.5是?????????€牂????€??€午???丠？？

简介：三新sesquiterpene碱，1-desacetylwilforgine(1)，1-desacetylwilforine(2)，和9鈥?hydroxy-2-nicotinoylwilforine(3)从Tripterygiumwilfordii钩f.的根被孤立，与六已知的碱一起。他们的结构被建立根据光谱分析。

简介：现在的学习被设计决定Pinelliapedatisecta的茎tuber的化学成分。化学成分被各种各样的色析法的技术，和他们的结构孤立并且净化根据物理化学的性质被阐明并且光谱数据。三新碱(加重1，2，和3)作为9-被获得并且识别((5-methoxypyridin-2-yl)甲基)-9H-purin-6-amine(1)，4-(2-(2，5-dioxopyrrolidin-1-yl)乙醇)苯基醋酸盐(2)，并且N-(9-((5-methoxypyridin-2-yl)甲基)-9H-purin-6-yl)acetamide(3)。这些混合物与人的颈的癌症HeLa房间为他们的cytotoxicity被作比较。混合物1和3显著地与是的IC50价值禁止了HeLa房间的增长3.02???????┱??????????????愠摮潲牧灡潨楬敤？？

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简介：ChemicalinvestigationontheethanolextractfromtherootsofSpiraeajaponicavar.acutaresultedintheisolationoftwonewditerpenealkaloidsnamedspiratinesAandB(1-2),respectively.

简介：二新-carboline-type碱，dichotomineK(1)和dichotomineL(2)，从中国药用的植物StellariadichotomaL的根被孤立。var。lanceolataBge。1和2的结构根据化学、分光镜的工具被决定。

简介：AIM:ToestablishamethodtosimultaneouslydeterminethemainfivealkaloidsofCatharanthusroseusfortracesamples,ahigh-performanceliquidchromatography–electrosprayionization-tandemmassspectrometry(HPLC-ESI-MS/MS)analysismethodwasdeveloped.METHOD:ThefiveCatharanthusalkaloids,vinblastine,vincristine,vinleurosine,vindoline,andcatharanthinewerechromatographicallyseparatedonaC18HPLCcolumn.Themobilephasewasmethanol-15nmol?L–1ammoniumacetatecontaining0.02%formicacid(65:35,V/V).ThequantificationofthesealkaloidswasbasedontheMultipleReactionMonitoring(MRM)mode.RESULTS:Thismethodwasvalidated,andtheresultsachievedtheaimsofthestudy.Theintra-andinter-dayprecisionandaccuracyofthefivealkaloidswerewithin1.2%-11.5%(RSD%)and-10.9%-10.5%(RE%).Therecoveryratesofthefivealkaloidsofsampleswerefrom79.9%to91.5%.Thefiveanalyteswerestableatroomtemperaturefor2h,at4°Cfor12h,andat-20°Cfortwoweeks.ThedevelopedmethodwasappliedsuccessfullytodeterminethecontentofthefivealkaloidsinthreeplantpartsofthreebatchesofC.roseuswithaminuteamountcollectedfromthreeregionsofChina.CONCLUSION:TheHPLC-ESI-MS/MSmethodcanbeusedforthesimultaneousdeterminationoffiveimportantalkaloidsintraceC.roseussamples.

简介：一新stenine类型碱，和五已知的stenine类型碱(2–6)和二已知的stemoninine类型碱(7和8)，tuberostemonineD(1)从Stemonatuberosa的根被孤立。他们的结构被广泛的分光镜的方法阐明(红外，紫外，MS，1D和2DNMR)，并且1的结构被X光检查衍射分析进一步证实。stenine类型和stemoninine类型碱的第一同时的隔离不仅增加了一种新化学类型并且增加了Stemonatuberosa的化学差异，而且为在类Stemona和Stichoneuron之间的靠近的关系提供了chemotaxonomic线索，并且赞成了在一样的家庭保留他们。

简介：bicyclo[2.2.2]与在C-8和C-9的一枚内酯的戒指，atisine类型C20-diterpenoid碱，辛烷C/D戒指系统成功地被综合，用氧化dearomatization/intramolecularDielsAlder反应。

简介：Despitetheadvancesincombinatorialorsyntheticchemistryandbioinformatics,recentliteraturehasdemonstratedtherelevanceofnatureandbiomassasasourceofnewmoleculestotreatdifferentpathologies,i.e.,bioactivecompoundsobtainedfromEcteinascidiaturbinatetotreatsometypesofcancerorrapamycinfromStreptomyceshygroscopicustopreventorganrejectionaftertransplant.Thistrend

简介：SophoraeFlavescentisRadix(SophoraflavescensAit.,SFR)andSophoraeTonkinensisRadixetRhizoma(S.tonkinensisGapnep.,STR)aretwocommonlyusedtraditionalChinesemedicinesfromSophora(Leguminosae)plants,whicharebelievedtopossesssimilarbioactivecomponentswithentirelydifferentclinicalapplications.InordertofindoutthecharacteristicchemicalconstituentspotentiallyleadingtotheuniquemedicinalpropertiesclaimedforeachofthetwocloselyrelatedTCMs,anHPLCfingerprintmethodwasdevelopedforanalysesofthealkaloidandflavonoidconstituentsofSFRandSTR,respectively,whichwerefurtherevaluatedandcomparedthroughsimilaritycalculationandhierarchicalclusteringanalysis(HCA).Theresultsfromthepresentstudyshowedthatthealkaloidfingerprintsofthetwoherbsweresimilar,withmanycomponentsco-existinginbothdrugsandvariousbatchesofsamplesfromdifferentspeciesbeingmixedtogetherintheHCAdendrogram.However,theirflavonoidconstituentsweretotallydifferentwithspecificfingerprintsbeingyieldedforeachherb,andfurtherHCAanalysisshowedthatthetestedsamplescouldalmostbeclearlydividedintotwogroupsbasedontheiroriginsofspecies.TheresultsfromthepresentstudyindicatedthattheflavonoidconstituentscouldserveasthedifferentiallydiagnosticconstituentsofSFRandSTRandmightpotentiallyattributedtotheirdistincttherapeuticeffects.