简介：Objective:Toreportthedevelopmentofatechniqueforminimallyinvasivethyroidlobectomy.Method:Theprocedurewasacceptedby200patientswithanoduleofthelobeofthethyroid.Weperformedhemithyroidectomysthrougha2-4cmlow-collarhorizontalskinincisionbyconventionalinstrumentation.Results:Therecurrentlaryngealnerveandtheparathyroidglandswereeasilyidentifiedandpreserved.Theamountofbleedingrangedfrom5to50ml(mean15ml).MeanOperationtimewas52.2minutes(ranged32to80minutes).Nocomplicationoccurred.Meanpostoperativestaywas5.5days(ranged4to7days).Theincisionprovidedexcellentcometicresultsbecausethesmallandlowerincisionswerecompletelyhiddenbyclothingcollar.Conclusion:Theabovetechniqueisfeasible,safe,minimallyinvasive,lesstimeandcostconsumingandcosmetical.

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简介：Haemangiopericytoma(HPC)isararevasculartumorwithborderlinemalignancy,considerablehistologicalvariability,andunpredictableclinicalandbiologicalbehavior.HPCcanpresentadiagnosticchallengebecauseofitsindeterminateclinical,radiological,andpathologicalfeatures.HPCgenerallypresentsinadulthoodandisequallyfrequentinbothsexes.HPCcanariseinanysiteinthebodyasaslowlygrowingandpainlessmass.TheprecisecelltypeoriginofHPCisuncertain.OnethirdofHPCsoccurintheheadandneckareas.Exceptionalcasesofhemangioblastomaarisingoutsidetheheadandneckareashavebeenreported,butlittleisknownabouttheirclinicopathologicandimmunohistochemicalfeatures.Thisstudyreportsonacaseofalargesacro-anteriorHPCina65-year-oldmale.

简介：BackgroundTheVisibleHumanProject(VHP)initiatedbytheU.S.NationalLibraryofMedicinehasdrawnmuchattentionandinterestsfromaroundtheworld.TheVisibleChineseHuman(VCH)projecthasstartedinChina.ThecurrentstudyaimsatacquiringafeasiblevirtualmethodologyforreconstructingthetemporalboneoftheChinesepopulation,whichmayprovideanaccurate3-Dmodelofimportanttemporalbonestructuresthatcanbeusedinteachingandpatientcareformedicalscientistsandclinicians.MethodsAseriesofsectionalimagesofthetemporalboneweregeneratedfromsectionslicesofafemalecadaverhead.Oneachsectionalimage,SOIs(structuresofinterest)weresegmentedbycarefullydefiningtheircontoursandfillingtheirareaswithcertaingrayscalevalues.Theprocessedvolumedataweretheninductedintothe3DSlicersoftware(developedbytheSurgicalPlanningLabatBrighamandWomen'sHospitalandtheMITAILab)forresegmentationandgenerationofasetoftaggedimagesoftheSOIs.3DsurfacemodelsofSOIswerethenreconstructedfromtheseimages.ResultsThetemporalboneandstructuresinthetemporalbone,includingthetympaniccavity,mastoidcells,sigmoidsinusandinternalcarotidartery,weresuccessfullyreconstructed.Theorientationofandspatialrelationshipamongthesestructureswereeasilyvisualizedinthereconstructedsurfacemodels.ConclusionThe3DSlicersoftwarecanbeusedfor3-dimensionalvisualizationofanatomicstructuresinthetemporalbone,whichwillgreatlyfacilitatetheadvanceofknowledgeandtechniquescriticalforstudyingandtreatingdisordersinvolvingthetemporalbone.

简介：AbstractObjective:There has been a significant shift from open craniofacial resection of the anterior skull base to endoscopic approaches that accomplish the same outcomes in tumor ablation. However, when open resection is required, free flap reconstruction is often necessary to provide sufficient well-vascularized tissue for optimal wound healing as well as providing adequate tissue bulk for cosmesis. This articleaims to providea focused review of free flaps most commonly used in anterior skull base reconstruction.Methods:This is a state-of-the-art review based on expert opinion and previously published reviews and journal articles, queried using PubMed and Google Scholar.Results & conclusion:Anterior skull base reconstruction via free tissue transfer is imperative in limiting complications and promoting healing, particularly with large defects, post-radiation, and in at-risk patients. The type of free flap utilized for a particular anterior skull base reconstruction should be tailored to the patient and nature of the disease. This review offers insight into the numerous reconstructive options for the free flap surgeon.

简介：DearEditor,Adenocarcinomaofthenonpigmentedciliaryepithelium(NPCE)isararemalignanttumorwhichisnoteasytobefoundintheearlystage~([1]).Herein,wereportacaseofadenocarcinomaoftheNPCEinaChineseboyanddiscussits

简介：Thispaperanalysestheanteriordescendingbranchofthearteriacoronariasinistrafromtheviewofhemodynamics.Theresultsshowthatthebranchingoftheanteriordescendingbranchwithanangleof90°attheopeningandtheformationofthemuralarteriacoronariaarethehemodynamiccharacteristics.Theshearingstressoftheturbulentflow,theadditionalpressure,theformationofthebloodvertex,andtheimpulsivepressure,causedbythesecharacteristics,arehemodynamicreasonsthatleadstotheoccurenceofatherosclerosisinanteriordescendingbranch.

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简介：Inordertounifythetimeandthespaceattributesintotemporal-spatialdistance,thetemporal-spatialproportionalcoefficientfTSisproposedinthispaper.Inaccordancewiththenewdistanceconcept,thetemporal-spatialcorrelativitywithintemporaldoubletsofstrongearthquakesinNorthChinaanditsvicinitysinceAD1500hasbeenanalyzed.ThecomputationresultsindicatethatdoubletsofstrongearthquakecanbedividedintotwogroupswhenfTSisendowedwith10km/ainthenewdistanceformula.Thetemporal-spatialdistancebetweentwopointsofdoubletgenerallycannotexceed140kmwhentwostrongquakesindoublethavesomecausativerelation.Andthosedoubletswithtemporal-spatialdistanceexceeding280kmareprobablyindependentseismiceventsindoublets.Thischaractercanbethereferencetothemigrationlawsummarizationandtrendprediction.

简介：Twodifferentpulsecleaningtechniquesforultra-highcontrastlasersystemsarecomparablyanalysedinthiswork.Thefirstpulsecleaningtechniqueisbasedonnoncollinearfemtosecondoptical-parametricamplification(NOPA)andsecond-harmonicgeneration(SHG)processes.Theotherisbasedoncross-polarizedwave(XPW)generation.Withadoublechirpedpulseamplifier(double-CPA)scheme,althoughtemporalcontrastenhancementinahigh-intensityfemtosecondTi:sapphirechirpedpulseamplification(CPA)lasersystemcanbeachievedbasedonbothofthetechniques,thetwodifferentpulsecleaningtechniquesstillhavetheirownadvantagesandaresuitablefordifferentcontrastenhancementrequirementsofdifferentlasersystems.

简介：Asmostgenesequencesandfunctionalstructuresofinternalorgansinratshavebeenwellstudied,ratmodelsarcwidelyusedinexperimentalmedicalstudies.Alargenumberofdescriptionsandatlasoftherattemporalbonehavebeenpublished,butsomedetailedanatomyofitssurfaceandinsidestructuresremainstobestudied.Byfocusingonsomeuniquecharacteristicsoftherattemporalbone,thecurrentpaperaimstoprovidemoreaccurateanddetailedinformationonrattemporalboneanatomyinanattempttocompletemissingorunclearareasintheexistedknowledge.Wealsohopethispapercanlayasolidfoundationforexperimentalrattemporalbonesurgeries,andpromoteinformationexchangeamongcolleagues,aswellasprovidingusefulguidancefornoviceresearchersinthefieldofhearingresearchinvolvingrats.

简介：Preparationofthetemporalboneforlightmicroscopyisanimportantstepinhistologicalstudiesoftheinnerear.Duetothecomplexityofstructuresoftheinnerear,itisdifficulttomeasureorcomparestructuresofinterestwithoutacommonlyacceptedstandardizedmeasureoftemporalbonesections.Therefore,standardizationoftemporalbonesectionsisveryimportantforhistologicalassessmentofsensoryhaircellsandperipheralganglionneuronsinthecochlearandvestibularsystems.Thestandardizedtemporalbonesectioningisorientedtoaplaneparalleltotheouterandinternalauditorycanals.Sectionsarecollectedfromtheepitympanumtothehypotympanumtoreveallayersintheorderofthecristaampullarisofthesuperiorandlateralsemicircularcanals,maculautriculiandmaculasacculi,superiorvestibularganglionneurons,maculaofsacculeandinferiorvestibularganglionneurons,cochlearmodiolus,endolymphaticductandendolymphaticsac,andfinallythecristaampullarisoftheposteriorsemicircularcanal.Moreover,technicaldetailsofpreparingfortemporalbonesectioningincludingfixation,decalcification,wholetemporalbonestaining,embeddingpenetration,andembeddingorientationarealsodiscussed.

简介：Thisresearchtakestheviewthatthemodellingoftemporaldataisafundamentalsteptowardsthesolutionofcapturingsemanticsoftime.Theproblemsinherentinthemodellingoftimearenotuniquetodatabaseprocessing.Therepresentationoftemporalknowledgeandtemporalreasoningarisesinawiderangeofotherdisciplines.Inthispaperanaccountisgivenofatechniqueformodellingthesemanticsoftemporaldataanditsassociatednormalizationmethod.ItdiscussesthetechniquesofprocessingtemporaldatabyemployingaTimeSequence(TS)datamodel.Itshowsanumberofdifferentstrategieswhichareusedtoclassifydifferentdatapropertiesoftemporaldata,anditgoesontodevelopthemodeloftemporaldataandaddressesissuesoftemporaldataapplicationdesignbyintroducingtheconceptoftemporaldatanormalisation.

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简介：AbstractPurpose:No therapeutic consensus has been established about proximal ruptures of the rectus femoris muscle. The objective of this literature review is to determine a therapeutic course of action.Methods:We conducted a literature review on the PubMed database using the following keywords (in French and English, respectively): "quadriceps/quadriceps", "droit antérieur/rectus femoris", "proximal/proximal", "chirurgie/surgical", "avulsion/avulsion". We collected 266 articles, 36 of them were selected, which were related to our topic: proximal rupture of the anterior rectus femoris. Patients with a proximal rupture of the rectus femoris, minor or major patient of traumatic origin were included in this study. Patients injured at another lesion level, or non-traumatic lesions of the proximal rectus femoris (tendinitis without ruptures, tumor or others) were excluded. For each patient, the indications, the type of treatment and the functional result were analyzed, with the time to recovery and the level of recovery from sports and professional activities (same sport/profession or not, same level or not) as the main criterion of judgment. Fisher exact test was used for statistical comparison.Results:The aims of conservative treatment are to be pain free for the patient, to fight hematoma and to rehabilitate the injury as quickly as possible. The surgical techniques are varied, with most consisting of either a reinsertion of the musculo-tendon stump or a resection of the scar tissue with myo-tendino-aponeurotic suture in place. The functional results are good for the majority of the treatments proposed, but the conservative treatment has a shorter recovery time (3 months vs. 4 months for the best surgical results). Highly displaced bone avulsion is the only indication for first-line surgical treatment.Conslusion:The main disadvantage of conservative treatment is the risk of residual pain beyond 3 months (10%), justifying an MRI to guide secondary surgical treatment. We propose a treatment plan for proximal rupture of the proximal rectus femoris rupture.

简介：Ifsystolicanteriormotion(SAM)ofaredundantanteriorleafletofthemitralvalveiscombinedwithsystolicthickeningofanasymmetricseptum,(ASH),anarrowoutflowchanneloftheleftventricleisformed.Thisnarrowedoutflowchannelisthenresponsibleforthemidsystolicpressuredifferencebetweenthebodyoftheleftventricleandtheoutflowareaoftheleftventricle.Thisresultsinhypertrophic“obstructive”cardiomyopathy(HOCM).

简介：TheundecapeptidesubstanceP(SP)wasshowntobeintimatelyinvolvedinboththestructuralandfunctionalaspectsoftheanteriorpituitary.Yet,inadditiontoitsinfluencesonhormonalsecretion,SPmaywellpossessmoreactionsinthismastergland.ThepresentstudywasfthereforeaimedtoinvestigatetheeffectofSPontheproliferationofratanteriorpituitarycellsinprimaryculture,ItwasfoundthatSPcoulddose-dependentlyincreasetheincorporationoftritiatedthymidine(3H-TdR)intoculturedanteriorpituitarycells.OthermammaliantachykininssuchasneurokininAandneurokininBhadsimilareffectbuttovaryingdegrees.TheequipotentanalogueofSP,Norleucine^11-SP(Nle^11-SP),alsoactedlikewise.withitsactionantagonizablebyspantide,aSPreceptorblocker.TofurthercharacterizethenatureofcellsresponsivetothechallengeofSP,immunocytochemicalstainingagainstS-100proteinandsomeadenohypophysealhormoneswasperformedaloneorplusautoradiography.TheresultsshowedthatthepercentageofS-100proteinimmunorectivecellswasapparentlyelevatedbytheaddtionofNle^11-Spfor48h,whichindicatesapreferentialproliferationoffolliculo-stellatecellsundertheregime.ThiswasconfirmedbyincreasesinimmunocytochemicalorautoradiographicallabellingindicesofanteriorpituitarySubstancePandanteriorpituitarycellproliferation.Cellstreatedsimilarly.Takentogether,TheseresultsrevealthatthetrophicactionofSPobservedpreviouslyinothertissuesisalsopresentatleastinculturedratanteriorpituitarycells.withrespondingcellsbeingpredominantlyfolliculo-stellatecellsastypifiedbyS-100proteinimmunoreactivity.Therefore,anintra-pituitarytrophicactionofSPinvivocouldbeanticipated.

简介：AbstractBackground:The first-line treatment for lung cancer is surgical resection, and one-lung ventilation (OLV) is the most basic anesthetic management method in lung surgery. During OLV, inflammatory cytokines are released in response to the lung tissue damage and promote local and contralateral lung damage through the systemic circulation. We designed a randomized, prospective study to evaluate the effect of the urinary trypsin inhibitor (UTI) ulinastatin on the inflammatory response after video-assisted thoracic lobectomy in patients with lung cancer.Methods:Adult patients aged 19 to 70 years, who were scheduled for video-assisted thoracic lobectomy surgery to treat lung cancer between May 2020 and August 2020, were enrolled in this randomized, prospective study. UTI (300,000 units) mixed with 100 mL of normal saline in the ulinastatin group and 100 mL of normal saline in the control group was administered over 1 h after inducing anesthesia.Results:The baseline (T0) interferon-γ (IFN-γ)/interleukin-4 (IL-4) ratio was not different between the groups (6941.3 ± 2778.7 vs. 6954.3 ± 2752.4 pg/mL, respectively; P > 0.05). The IFN-γ/IL-4 ratio was significantly higher in ulinastatin group at 30 min after entering the recovery room than control group (20,148.2 ± 5054.3 vs. 6674.0 ± 2963.6, respectively; adjusted P < 0.017). Conclusion: Administering UTI attenuated the anti-inflammatory response, in terms of INF-γ expression and the IFN-γ/IL-4 ratio, after video-assisted thoracic surgery in lung cancer patients.Trial registration:Clinical Research Information Service of Korea National Institute of Health (CRIS), KCT0005533.

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