简介:7月22日,Beyend三人开完了在内地最后一场解散前的巡演,之后,这个永生的乐队,成为永远的纪念或遗憾。
简介:<正>FewWesternersknowmuchaboutPakistanbeyondmediareportsofIslamicfundamentalism,communalviolenceandmartiallaw,butitcontainssomeofAsia’smostmind-blowinglandscapes,extraordinarytrekkingopportunities,amultitudeofculturesandalongtraditionofhospitality.TheChina’sneighbouringcountryisthesiteofsomeoftheearliesthumansettlements,hometoanancientcivilisationrivallingthoseofEgyptandMesopotamia,andthecrucibleoftwooftheworld’smajorreligions,HinduismandBuddhism.You’llsurelygetmorethanwhatyouexpectedthere..
简介:Hypertensionisaleadingriskfactorforcardiovasculardisease,theleadingcauseofdeathandmorbidityinoursocietyandonaglobalscale.Majorcomponentsofcardiovasculardiseaseincludestroke,coronaryarterydisease,heartfailure,andchronickidneydisease,inallofwhichhypertensionplaysamajorrole.Theriskofthesecomplicationsincreasesdirectlyandlinearlywithsystolicbloodpressurestartingat115mmHg.Althoughusuallyasymptomatic,hypertensionisreadilydetectableonphysicalexaminationandisamenabletobothlifestylemodificationandpharmacologictreatmentinmostpatients.However,largeproportionsofthehypertensivepopulationremainundetectedandundertreated.Numerousguidelineshavebeenissuedduringthepastfewdecadestopromotedetectionandoptimaltherapy.Despitetheincreaseinriskwithsystolicbloodpressuregreaterthan115mmHg,thegenerallyacceptedthresholdfordiagnosisandtreatmenthasbeensystolicbloodpressuregreaterthan139mmHganddiastolicbloodpressuregreaterthan80mmHgbecauseuntilrecentlytreatmenttolowerlevelshasbeenassociatedwithanunfavorablerelationbetweenclinicalbenefitandharm.Inthepastseveralyears,newguidelines,advisories,commentaries,andclinicaltrialshaveprovidedevidenceforapotentialchangeincurrentrecommendationsforthemanagementofhypertension.Inthisregard,thelong-awaitedeighthreportoftheJointNationalCommitteeonthePrevention,Detection,Evaluation,andTreatmentofHighBloodPressurerecommendedpatientsolderthan60yearsbetreatedtoasystolicbloodpressureoflessthan150mmHg,whichhasgeneratedconsiderablecontroversyandcaution.ThestrikingfindingsoftheSystolicBloodPressureInterventionTrial(SPRINT)havereceivedconsiderableattentionbecauseofthedemonstrationthatintensivetherapytoatargetsystolicbloodpressurebelow120mmHgdecreasescardiovascularmortalityandmorbiditymorethanlessintensivetreatmenttoatargetsystolicbloodpressurebelow140mmHg
简介:<正>IncelebrationofthediscoveryofthestructureofDNA-thesecretcodedlanguageoflife-intheUK50yearsago,theexhibitionDNA50:Watson,CrickandBeyond,willvisitBeijinginSeptemberandOctober,unlockingsomeofthemysteriesofthismonumentaldiscovery.OrganisedbytheBritishCouncilandtheChineseAcademyofScience,andsponsoredbyGlaxoSmithKline,theexhibitionwilltakeplaceatXinDongAnShopping
简介:AbstractSepsis remains a significant cause of neonatal morbidity and mortality in China. A better understanding of neonatal sepsis in China as compared with other industrialized and non-industrialized countries may help optimize neonatal health care both regionally and globally. Literature cited in this review was retrieved from PubMed using the keywords "neonatal sepsis," "early-onset (EOS)" and "late-onset (LOS)" in English, with the focus set on population-based studies. This review provides an updated summary regarding the epidemiology, pathogen profile, infectious work-up, and empirical treatment of neonatal sepsis within and beyond China. The incidence of neonatal EOS and the proportion of Group B Streptococcus (GBS) within pathogens causing EOS in China seem to differ from those in developed countries, possibly due to different population characteristics and intrapartum/postnatal health care strategies. Whether to adopt GBS screening and intrapartum antibiotic prophylaxis in China remains highly debatable. The pathogen profile of LOS in China was shown to be similar to other countries. However, viruses as potential pathogens of neonatal LOS have been underappreciated. Growing antimicrobial resistance in China reflects limitations in adapting antibiotic regimen to local microbial profile and timely cessation of treatment in non-proven bacterial infections. This review stresses that the local epidemiology of neonatal sepsis should be closely monitored in each institution. A prompt and adequate infectious work-up is critically important in diagnosing neonatal sepsis. Adequate and appropriate antibiotic strategies must be overemphasized to prevent the emergence of multi-resistant bacteria in China.
简介:Surgicaloptionsdevelopedtotreatcarotidarterystenosishaveevolvedinthelastsixdecades,andstudieshaveshownthesuperiorityofcarotidendarterectomy(CEA)comparedtomedicaltherapy.Similarly,asendovasculartherapyhasevolvedoverthelasttwodecades,studiesreflectingsafety,feasibility,andequivalenceofcarotidarterystenting(CAS)toCEAhavebeenreplicatedinseveralstudiesforintermediatetohighsurgicalriskpatients.However,sinceitsinception,thefieldofCAShasbeenmiredinseveralcontroversiesandhasbeensubjecttointensescrutinyfrommultiplestakeholderswithinthefieldofmedicine.ThisreviewdiscussesspecificissuesconcerningCASthatarerelevantinthecurrentera.
简介:Accountingscandalsarebecomingperpetualinnature.TheyrangefromtheancientMesopotamia,totheSouthSeaBubbleof1720,tothefamousEnronof2001,downtoParmalat,Tesco,andToshibaoftoday.Theseriesofaccountingscandalsthathaveoccurredinthelasttwodecadescallsforagreaterconcernbytheaccountingprofession.Theaccountingscandalsthathaveoccurredinthis21stcenturyalonehaveshownthatthereisaneedtolookbeyondcorporategovernanceinthefightagainstfinancialdeception.Inthispaper,wearguethateveninthefaceoftheSarbanes-OxleyAct(SOA)of2002andotherregulationsaroundtheworldthataretargetedtowardseffectivecorporategovernance,accountingscandalshaveneverceasedtooccur.Mostofthelegislationsthathavebeenpassedinrecenttimesweretargetedatcorporategovernance,forgettingthecrucialrolethatauditplayswithintheagencyrelationship.Andwheneverthereisanyrevelationoffraudulentfinancialreporting,investorsdonotaskwhoarethedirectors,butthefirstquestiontheyaskiswhoaretheauditors?Hence,thereisaneedtoimproveauditqualitybyapproachingitfromaforensicaccountingperspectiveinordertoreducetheincidenceoffinancialstatementfraudsinthiseraofinformationrevolution,thusrestoringinvestors’confidencebackinthefinancialreportingprocessandcorporategovernance.Inthispaper,weproposeaforensicaccountingparadigmasaviableoptionforreducingaccountingscandals,sincethiswillcomplimentcorporategovernancesystems.
简介:在肿瘤开始的癌症干细胞(CSC)的重要性坚定地在白血病被建立了并且最近为许多稳固的肿瘤报导了。然而,特别地关于转移,在多级式的癌症前进的CSC的角色有不定义beenwell。癌症转移要求在远机关播种和specializedCSCs的成功的殖民。正常干细胞和CSC的生物学分享显著类似并且当适用于癌症的学习时,可以有重要含意转移。而且,重叠分子和小径的集合最近被识别了调整干细胞移植和癌症转移。这些分子组成两个都为移植CSC由主要肿瘤和养育的机关微型环境的形成便于转移前壁龛的开始的细胞的相互作用的一个复杂网络。在这评论,我们在这个动态领域里调查了最近的进展并且建议CSC在tumorigenesis和转移在假定一个中央角色的癌症前进的一个统一模型。更好作为变形串联的一个基本部件理解ofCSCs将对变形癌症导致新奇治疗学的策略。
简介:Realizationofnationalunity,independenceandprosperityhaslongbeenthecherisheddreamoftheentireChinesepeopleforgenerationseversincethehu-miliating1840OpiumWar.WhenMaoZedongannouncedin1949thatthe“the