简介：Cerebralischemianotonlycausespathologicalchangesintheischemicareasbutalsoinducesaseriesofsecondarychangesinmoredistalbrainregions(suchasthecontralateralcerebralhemisphere).Theimpactofsupratentoriallesions,whicharethemostcommontypeoflesion,onthecontralateralcerebellumhasbeenstudiedinpatientsbypositronemissiontomography,singlephotonemissioncomputedtomography,magneticresonanceimaginganddiffusiontensorimaging.Inthepresentstudy,weinvestigatedmetabolitechangesinthecontralateralcerebralhemisphereaftersupratentorialunilateralischemiausingnuclearmagneticresonancespectroscopy-basedmetabonomics.Thepermanentmiddlecerebralarteryocclusionmodelofischemicstrokewasestablishedinrats.Ratswererandomlydividedintothemiddlecerebralarteryocclusion1-,3-,9-and24-hourgroupsandtheshamgroup.~1Hnuclearmagneticresonancespectroscopywasusedtodetectmetabolitesintheleftandrightcerebralhemispheres.Comparedwiththeshamgroup,theconcentrationsoflactate,alanine,γ-aminobutyricacid,cholineandglycineintheischemiccerebralhemispherewereincreasedintheacutestage,whiletheconcentrationsofN-acetylaspartate,creatinine,glutamateandaspartateweredecreased.Thisdemonstratesthatthereisanupregulationofanaerobicglycolysis(shownbytheincreaseinlactate),aperturbationofcholinemetabolism(suggestedbytheincreaseincholine),neuronalcelldamage(shownbythedecreaseinN-acetylaspartate)andneurotransmitterimbalance(evidencedbytheincreaseinγ-aminobutyricacidandglycineandbythedecreaseinglutamateandaspartate)intheacutestageofcerebralischemia.Inthecontralateralhemisphere,theconcentrationsoflactate,alanine,glycine,cholineandaspartatewereincreased,whiletheconcentrationsofγ-aminobutyricacid,glutamateandcreatinineweredecreased.Thissuggeststhatthereisadifferenceinthemetabolitechangesinducedbyischemicinjuryinthecontral

简介：在反脉管的endothelial生长的一个年以后与有斑点的浮肿的分辨率和foveal消沉的恢复在眼睛报导foveal厚度减小为包含中心的糖尿病的有斑点的浮肿(DME)的因素(anti-VEGF)治疗.METHODSFoveal厚度与光连贯断层摄影术被估计决定中央子字段foveal厚度(CSFT)并且在有DME的42只眼睛的有斑点的体积(CSFT>275湥獴愠?潣灭牡摥琠?敨污桴?潣瑮潲?牧畯？

简介：Intracerebralhaemorrhage（ICH）,whichhasrapidattackandhighdeathrate,usuallyleadstobadoutcomes.Poorprognosisofthisdiseaseisprimarilyduetothedifficultyofearlydiscovery.Earlydetectionordiagnosiswouldsignificantlyreducetherateofdisabilityandmortality,andimprovetheprognosisofthepatients.Thepurposeofthispaperistotestifyelectricalimpedancechangeanddetectionofbraintissueaftercerebralischemicwithelectricalimpedancetomography.Inthisstudy,electricalimpedancetomography（EIT）wasappliedtodetecttheonsetofmodeledonrabbitsinrealtime,ICHmodelgroupwereinjectedcollagenaseintheCorpusStriatumwhilerabbitsincontrolgroupwereinjectedthesamevolumeofsalinewithcollagenase.Thesubsequentprocesswasmonitoredcontinuouslybysystemofelectricalimpedancetomography;therabbitsweresacrificedbyintravenousinjectionofoverdoseofhydrationchlorinealdehyde,andthentakenintobeingscannedbycomputedtomography（CT）witharesolutionof1mmwithin10minafterdeath.Afterthat,thebrainsoftherabbitsweretakenout,fixedandcutintoslicestodetectthechangesofbraintissue.Wefoundthatone-dimensionalimpedanceandtwo-dimensional（2D）imagesofelectricresistanceofbrainoftherabbitspretreatedwithcoilagenaseobviouslychangedafterinjectionandthehemorrhagecouldbefoundintheslicesofbrainandtherewerechangesinthemodelrabbitsgroupnotonlytheelectricresistancebutalsothebraintissues.quantitativeindexcan＇tbeprovidedbydetectionofintracerebralhemorrhageAlthoughinrabbitswithelectricalimpedancetomography＇satthisstage,cerebralhemorrhagecancausebrainelectricalimpedancecharactersofthechange,thecompletedexperimentssuggestthatelectricalimoedancetomograophr（EIT）maybecomeaneffectivetechniauetodetectICH.

简介：Inflammationafterstrokeisthemaincauseofcerebralischemia/reperfusioninjury.Cascadingeventsafterinjurycanleadtocelldeath.Heatshockprotein70andotherendogenousinjury-signalingmoleculesarereleasedbydamagedcells,whichcanleadtosystemicstressreactions.Protectingthebrainthroughrepairbeginswiththestress-injury-repairsignalingchain.Thisstudyaimedtoverifywhetheracupunctureactsthroughthischaintofacilitateeffectivetreatmentofischemicstroke.Ratmodelsofcerebralischemia/reperfusioninjurywereestablishedbyZeaLonga'smethod,andinjurysiteswereidentifiedbyassessingneurologicalfunction,2,3,5-triphenyltetrazoliumchloridestaining,andhematoxylin-eosinstaining.ElectroacupunctureatacupointsBaihui(DU20)andZusanli(ST36)wasperformedinthemodelratswithdilatationalwaves,deliveredfor20minutesadayat2–100Hzandanamplitudeof2mA.Weanalyzedthebloodserumfromtheratsandfoundthatinflammatorycytokinesaffectedthelevelsofadrenotrophinandheatshockprotein70,eachofwhichfollowedasimilarbimodalcurve.Specifically,electroacupunctureloweredthepeaklevelsofadrenocorticotrophichormoneandheatshockprotein70.Thus,electroacupuncturewasabletoinhibitexcessivestress,reduceinflammation,andpromotetherepairofneurons,whichfacilitatedhealingofischemicstroke.

简介：Acupunctureiswidelyusedtotreatfunctionaldyspepsiawithsatisfactoryoutcomes.CombinationoftheHeandMuacupointsiscommonlyusedandhasasynergisticeffectonfunctionaldyspepsia;however,itsunderlyingmechanismsremainunclear.Therefore,arandomizedcontrolledparallelclinicaltrialiscurrentlyunderwayatChengduUniversityofTraditionalChineseMedicine,China.ThistrialisdesignedtoexploretheefficacyofandcentralresponsestotheHe-Mupointcombinationinpatientswithfunctionaldyspepsiausingfunctionalmagneticresonanceimaging.Atotalof105patientswithfunctionaldyspepsiawillbeallocatedinto3groups:thelow-Hepointgroup(puncturingatZusanli(ST36)),Mupointgroup(puncturingatZhongwan(CV12)),andHe-Mupointcombinationgroup(puncturingatST36andCV12).Everyparticipantwillreceive20sessionsofmanualacupuncturefor4weeks.Theneedleswillbeinsertedperpendicularlytoadepthof1to2cun.Theangleofrotationandtwistingwillrangefrom90to180degrees,whileliftingandthrustingwillrangefrom0.3to0.5cm.Thevariousmanipulationswillbeperformed60to90timesperminute.Theneedleswillremaininplacefor30minutes,duringwhichmanipulationwillbeappliedevery10minutes.Magneticresonanceimagingwillbeperformedbeforeandafter20sessionsofacupuncture.TheprimaryoutcomeissymptomimprovementaccordingtotheChineseversionoftheNepeanDyspepsiaIndex.SecondaryoutcomesincludetheLeedsdyspepsiaquestionnaire,Self-RatingAnxietyScale,Self-RatingDepressionScale,BeckAnxietyInventory,BeckDepressionInventory,andvisualanaloguescalescoresbeforeandafter10and20sessionsofacupuncture.Needlesensationandadverseeventswillbeusedtoassessthetherapeuticeffects.ThisstudywillpromotemorewidespreadawarenessofthebenefitsofacupointcombinationintheclinicalsettingandprovideafurtherexplanationoftheneuromechanismbywhichacupunctureattheHe-Mupointcombinationforfunctio

简介：Ischemicpreconditioningelicitedbyanon-fatalbriefocclusionofbloodflowhasbeenappliedforanexperimentaltherapeuticstrategyagainstasubsequentfatalischemicinsult.Inthisstudy,weinvestigatedtheneuroprotectiveeffectsofischemicpreconditioning(2-minutetransientcerebralischemia)oncalbindinD28kimmunoreactivityinthegerbilhippocampalCA1areafollowingasubsequentfataltransientischemicinsult(5-minutetransientcerebralischemia).AlargenumberofpyramidalneuronsinthehippocampalCA1areadied4daysafter5-minutetransientcerebralischemia.IschemicpreconditioningreducedthedeathofpyramidalneuronsinthehippocampalCA1area.CalbindinD28kimmunoreactivitywasgreatlyattenuatedat2daysafter5-minutetransientcerebralischemiaanditwashardlydetectedat5dayspost-ischemia.IschemicpreconditioningmaintainedcalbindinD28kimmunoreactivityaftertransientcerebralischemia.Thesefindingssuggestthatischemicpreconditioningcanattenuatetransientcerebralischemia-causeddamagetothepyramidalneuronsinthehippocampalCA1areathroughmaintainingcalbindinD28kimmunoreactivity.