简介：Sex-specificdifferencesintheepidemiologyandpathophysiologyofcoronaryarterydiseaseandischemicheartdiseasearenowwellrecognized.Womenwithanginamoreoftenhavenonobstructivecoronaryarterydisease(NOCAD)comparedwithmen.Thispatientpopulationcarriesasignificantriskoffuturecardiovasculareventsthatisnotcommonlyappreciated,oftenleadingtodelayeddiagnosisandtreatment.WhilecoronarymicrovasculardysfunctionplaysacentralroleinthepathophysiologyofNOCADinwomen,othermechanismsofmyocardialischemiaarenowrecognized.RiskfactorssuchashypertensionandobesitydisparatelyaffectwomenandarelikelytoaccountforasignificantproportionofNOCADinthecomingyears.VascularinflammationisanimportantpathophysiologicpathwayinNOCADandisapotentialtherapeutictarget.CoronaryCTangiographyprovidesacomprehensiveassessmentofcoronaryanatomyandplaquemorphologyandisareasonablescreeningtestofchoiceforNOCAD.

简介：Facede-identificationhasbecomeincreasinglyimportantastheimagesourcesareexplosivelygrowingandeasilyaccessible.Theadvanceofnewfacerecognitiontechniquesalsoarisespeople'sconcernregardingtheprivacyleakage.Themainstreampipelinesoffacede-identificationaremostlybasedonthek-sameframework,whichbearscritiquesofloweffectivenessandpoorvisualquality.Inthispaper,weproposeanewframeworkcalledPrivacy-Protective-GAN(PP-GAN)thatadaptsGAN(generativeadversarialnetwork)withnovelverificatorandregulatormodulesspeciallydesignedforthefacede-identificationproblemtoensuregeneratingde-identifiedoutputwithretainedstructuresimilarityaccordingtoasingleinput.Weevaluatetheproposedapproachintermsofprivacyprotection,utilitypreservation,andstructuresimilarity.Ourapproachnotonlyoutperformsexistingfacede-identificationtechniquesbutalsoprovidesapracticalframeworkofadaptingGANwithpriorsofdomainknowledge.

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简介：ThisstudydevelopedapopulationpharmacokineticmodelforsodiumtanshinoneIIAsulfonate(STS)inhealthyvolunteersandcoronaryheartdisease(CHD)patientsinordertoidentifysignificantcovariatesforthepharmacokineticsofSTS.Bloodsampleswereobtainedbyintensesamplingapproachfrom10healthyvolunteersandsparsesamplingfrom25CHDpatients,andapopulationpharmacokineticanalysiswasperformedbynonlinearmixed-effectmodeling.Thefinalmodelwasevaluatedbybootstrapandvisualpredictivecheck.Atotalof230plasmaconcentrationswereincluded,137fromhealthyvolunteersand93fromCHDpatients.Itwasatwo-compartmentmodelwithfirst-orderelimination.Thetypicalvalueoftheapparentclearance(CL)ofSTSinCHDpatientswithtotalbilirubin(TBIL)levelof10μmol(L?1was48.7L(h?1withinterindividualvariabilityof27.4%,whereasthatinhealthyvolunteerswiththesameTBILlevelwas63.1L(h?1.Residualvariabilitywasdescribedbyaproportionalerrormodelandestimatedat5.2%.TheCLofSTSinCHDpatientswaslowerthanthatinhealthyvolunteersanddecreasedwhenTBILlevelsincreased.Thebootstrapandvisualpredictivecheckconfirmedthestabilityandvalidityofthefinalmodel.TheseresultssuggestedthatSTSdosageadjustmentmightbeconsideredbasedonTBILlevelsinCHDpatients.

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简介：Photonics-basedradarwithaphotonicde-chirpreceiverhastheadvantagesofbroadbandoperationandreal-timesignalprocessing,butitsuffersfrominterferencefromimagefrequenciesandotherundesiredfrequency-mixingcomponents,duetosingle-channelreal-valuedphotonicfrequencymixing.Inthispaper,weproposeaphotonicsbasedradarwithaphotonicfrequency-doublingtransmitterandabalancedin-phaseandquadrature(I/Q)de-chirpreceiver.Thisradartransmitsbroadbandlinearlyfrequency-modulatedsignalsgeneratedbyphotonicfrequencydoublingandperformsI/Qde-chirpingoftheradarechoesbasedonabalancedphotonicI/Qfrequencymixer,whichisrealizedbyapplyinga90°opticalhybridfollowedbybalancedphotodetectors.Theproposedradarhasahighrangeresolutionbecauseofthelargeoperationbandwidthandachievesinterference-freedetectionbysuppressingtheimagefrequenciesandotherundesiredfrequency-mixingcomponents.Intheexperiment,aphotonics-basedK-bandradarwithabandwidthof8GHzisdemonstrated.ThebalancedI/Qde-chirpingreceiverachievesanimage-rejectionratioofover30dBandsuccessfullyeliminatestheinterferenceduetothebasebandenvelopeandthefrequencymixingbetweenradarechoesofdifferenttargets.Inaddition,thedesireddechirpedsignalpowerisalsoenhancedwithbalanceddetection.Basedontheestablishedphotonics-basedradar,inversesyntheticapertureradarimagingisalsoimplemented,throughwhichtheadvantagesoftheproposedradarareverified.