简介：Node.js是单线程,采用无阻塞I/O和异步事件模式.在本文中,讨论Node.js的异步编程模式：标准回调和事件驱动编程模式.

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简介：AIMTodeterminewhetherthenumberofexaminedlymphnodes(LNs)iscorrelatedwiththeoverallsurvivalofgallbladdercarcinoma(GBC)patients.METHODSPatientswerecollectedfromtheSurveillanceEpidemiologyandEndResultsdatabase(2004-2013)andcategorizedbythenumberofLNsintosixgroups:1LN,2LNs,3LNs,4LNs,5LNs,and≥6LNs.SurvivalcurvesforoverallsurvivalwereplottedwithaKaplan-Meieranalysis.Thelog-ranktestwasusedforunivariatecomparisons.RESULTSInacohortof893patients,themediannumberofexaminedLNswastwofortheentirecohort.Thesurvivalforthe1LNgroupwassignificantlypoorerthanthoseofthestageⅠandⅡdiseasegroupsandfortheentirecohort.BydichotomizingthenumberofLNsfrom1to6,wefoundthattheminimumnumberofLNsthatshouldbeexaminedwasfourforstageⅠ,fourorfiveforstageⅡ,andsixforstageⅢAdisease.Therefore,fortheentirecohort,thenumberofexaminedLNsshouldbeatleastsix,whichisexactlyconsistentwiththeAmericanJointCommitteeonCancercriteria.CONCLUSIONTheexaminationofhighernumbersofLNsisassociatedwithimprovedsurvivalafterresectionsurgeryforN0GBC.TheguidelinesforGBCsurgery,whichrecommendthatsixLNsbeexaminedatleast,arestatisticallyvalidandshouldbeappliedinclinicalpracticewidely.

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简介：Objective:Tocreateanomogramtopredicttheincidenceoflymphnodemetastasis(LNM)inearlygastriccancer(EGC)patientsandtoexternallyvalidatethenomogram.Methods:Toconstructthenomogram,weretrospectivelyanalyzedaprimarycohortof272EGCpatients.Univariateanalysisandabinarylogisticregressionwereperformed.AnomogrampredictingtheincidenceofLNMinEGCpatientswascreated.Thediscriminationabilityofthenomogramwasmeasuredusingtheconcordanceindex(c-index),andthenomogramwasalsocalibrated.Then,anotherprospectivecohortof81patientswasanalyzedtovalidatethenomogram.Results:Intheprimarycohort,LNMwaspathologicallyconfirmedin37(13.6%)patients.Inmultivariateanalysis,thepresenceofanulcer,themaximumlesiondiameterobservedviagastroscopy,thethicknessofthelesionobservedviaendoscopicultrasonography,andthepresenceofenlargedlymphnodesoncomputedtomography(CT)wereindependentriskfactorsforLNM.Anomogramwasthencreatedbasedontheregressionmodelwiththec-indexof0.905,andthecalibrationcurveofthenomogramfellapproximatelyontheideal45-degreeline.Thecut-offscoreofthenomogramwas110,andthesensitivity,specificity,positivepredictiveandnegativepredictivevaluesofthenomogramintheprimarycohortwere81.1%,86.0%,47.6%and96.7%,respectively,andintheprospectivevalidationcohortwere75.0%,91.0%,60.0%and95.5%,respectively.Thecalibrationcurveoftheexternalvalidationcohortwasalmostonthe45-degreeline.Conclusions:WedevelopedaneffectivenomogrampredictingtheincidenceofLNMforEGCpatients.

简介：Objective:Thisrandomizedstudyaimedtocomparetheclinicalefficacybetweenthenoveldualtracercomposedofindocyaninegreen(ICG)andbluedye(BD)andtheconventionaldualtracercomposedofradioisotopeandBDforsentinellymphnode(SLN)mappinginpatientswithbreastcancer.Methods:Thisstudyenrolled471clinicallylymphnode-negativepatientswithprimarybreastcancer.Allpatientsunderwentmastectomy,andthoseundergoingsentinellymphnodebiopsy(SLNB)wererandomizedtoreceivebluedyeplusradioisotope(RBgroup)orBDplusICG(IBgroup).ThedetectionperformancesonSLNidentificationrate,positiveSLNcounts,detectionsensitivity,andfalse-negativeratewerecomparedbetweenthetwogroups.Results:IntheIBgroup,97%(194/200)ofthepatientswhounderwenttheICGandBDdualtracerinjectionshowedfluorescentpositivelymphaticvesselswithin2–5min.TheidentificationrateofSLNswascomparablebetweentheIBgroup(99.0%,198/200)andtheRBgroup(99.6%,270/271)(P=0.79).NosignificantdifferenceswereobservedintheidentificationrateofmetastaticSLNs(22.5%vs.22.9%,P>0.05,RBgroupvs.IBgroup,thesamebelow),positiveSLNcounts(3.72±2.28vs.3.91±2.13,P>0.05),positivemetastaticSLNcounts(0.38±0.84vs.0.34±0.78,P>0.05),SLNBdetectionsensitivity(94.4%vs.92.5%,P>0.05),orfalse-negativerate(5.6%vs.7.5%,P>0.05)betweenthetwogroups.Conclusions:ICGcanbeusedasapromisingalternativetracerforradioisotopeinSLNmapping,andwhenitiscombinedwithBDinlymphangiography,itofferscomparabledetectionsensitivitycomparedtotheconventionallymphaticmappingstrategiesthatarewidelyusedinclinicalpractice.

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