简介：二维的polyacrylamide胶化电气泳动(2D页)并且帮助矩阵的激光解吸附作用/电离双人脚踏车time-of-flight团spectrometry(MALDI-TOF/TOF-MS)，与联机数据库寻找合并了，被执行调查乳癌和邻近的正常的微分蛋白质胸纸巾。考虑到那浆液白朊富有地在正常被介绍，控制样品，从12在11检测的15个微分点(91.7%)乳癌样品被联机SIENA-2DPAGE数据库寻找和MALDI-TOF/TOF-MS分析识别。结果显示乳癌的病理学的变化涉及物质新陈代谢的扩大，解朊的活动的提升，酶的一些禁止者的活动的衰落等等。与改变的表示涉及乳癌的病理学的进程的一些重要蛋白质可以是有用简历标记，例如alpha-1-antitrypsin，EF-1-beta，组织蛋白酶D，TCTP，SMT3A，RPS12，和PSMA1，SMT3A，RPS12，和PSMA1首先在这研究为乳癌在之中被报导。

简介：Theriskofbreastcancer(BC)overdiagnosisattributedtomammographyscreeningisanunresolvedissue,complicatedbyheterogeneityinthemethodologyofquantifyingitsmagnitude,andbothpoliticalandscientificelementssurroundinginterpretationoftheevidenceonthisphenomenon.EvidencefromrandomizedtrialsandalsofromobservationalstudiesshowsthatmammographyscreeningreducestheriskofBCdeath;similarly,thesestudiesprovidesufficientevidencethatoverdiagnosisrepresentsaseriousharmfrompopulationbreastscreening.Forboththeseoutcomesofscreening,BCmortalityreductionandoverdiagnosis,estimatesofmagnitudevarybetweenstudieshoweveroverdiagnosisestimatesareassociatedwithsubstantialuncertainty.Thetrade-offbetweenthebenefitandthecollectiveharmsofBCscreening,includingfalse-positivesandoverdiagnosis,ismorefinelybalancedthaninitiallyrecognized,howeverthesnapshotofevidencepresentedonoverdiagnosisdoesnotmeanthatbreastscreeningisworthless.Futureeffortsshouldbedirectedtowards(a)ensuringthatanychangesintheimplementationofBCscreeningoptimizethebalancebetweenbenefitandharms,includingassessinghowplannedoractualchangesmodifytheriskofoverdiagnosis;(b)informingwomenofalltheoutcomesthatmayaffectthemwhentheyparticipateinscreeningusingwell-craftedandbalancedinformation;and(c)investinginresearchthatwillhelpdefineandreducetheensuingovertreatmentofscreen-detectedBC.

简介：Breastcancerisoneofthemostcommoncancersaroundtheworldwithapproximately1.6millionnewcasesand425thousanddeathsfromthediseasein2010(1).Whileearlydetectionmethodsandtreatmenthavecontinuouslyevolvedandimprovedovertheyears,thereisstillastrong

简介：Objective:Tofindaneffective,sensitive,specificandnoninvasivediagnosticmethodofbreastcancer.Methods:109massesof102patientswithbreastlesionssmallerthan2cmindiameterweredividedintothreegroupstoundergo99mTc-MIBIimagingandcomparedwiththeresultsofpathologyexamination.20caseswithoutbreastlesionswereselectedascontrol.Abnormalcondensationof99mTc-MIBIinthebreastreaching10%higherthanthatinthecounterpartofthehealthybreastwasregardedaspositive.Results:Of32breastcancers,positiveimagingappearedin25.Negativeimagingwerefoundin31of38benignbreastlesions.Of39occultbreastlesions,positiveimagingappearedin6and3ofthemwerebreastcancer,2of3patientswithslightlyincreased99mTc-MIBIimagingthresholdwerebreastcanceralso.Nopositiveimagingwasfoundinthecontrolgroup.Thediagnosticaccuracy,sensitivity,specificity,positivepredictivevalue,negativepredictivevalueof99mTc-MIBIwas88.4%,89.2%,88.0%,75.0%and95.3%,respectively.Conclusion:99mTc-MIBIimaginghadhighersensitivityandaccuracyinthediagnosisofbreastcanceranddifferentiationbetweenbenignandmalignantbreastlesions.Itcouldprovideusefulinformationforthediagnosisofclinicallysuspectedbreastcancer.

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简介：Usingultrashort-pulseradarwithcompactvivaldiantennas,thesimulationexperimentofbreastcancerdetectionhasbeenperformedinasyntheticbreastphantom.Twometallicballswith9mmand6mmindiameterareusedastumorsinourexperiment.Theimagereconstructionsofthebreastmodelswithtumorsusingreflectiondatahavebeenpresentedbyaconfocalmicrowaveimagingtechnique.Themethodcanbeusedforapulsecompressiontechniquetoreflectedwavesforclearimageformation.

简介：Objective:Toinvestigatetheeffectofbreast-conservationtherapyinearlystagebreastcancer.Methods:Atotalof234earlystagebreastcarcinomapatientsreceivedbreastconservingtreatmentinourhospital.Aftertheoperation,theyunderwentadjuvantchemotherapyandradiotherapy.Allofthesepatientsdesiredtopreservetheirbreasts.Results:Aftermedianfollow-upof29.46months(rangefrom3to100months),3caseshadlocalrelapseand8caseshaddistantmetastasis.Theoverallsurvivalrateof5yearwas96.7%,andthediseasefreesurvivalrateof5yearwas87.85%.Conclusion:Forearlystagebreastcarcinomapatients,classicquadrantectomy,axillarydissectionandpost-operativeadjuvantchemotherapyandradiotherapyleadtoexcellentlocalcontrolandgoodsurvival.

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简介：Translationalresearch,ingeneral,meanstotakeknowledgefromoneareaintoasecond.Traditionalthoughttorepresenttransferofknowledgefrombasicresearchintotheclinic,translationalresearchtodaycoversamuchbroaderterm.Thus,mostinvestigatorswillagreetranslationalresearchcoversatwo-wayprocessthatalsoincludestakinglessonsfromtheclinicbacktothelaboratory,bywhichbiologicalobservationsinvivowouldcreatenovelhypothesestobefurtherexploredinlaboratoryexperiments.

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简介：客观：学习在胸方法的ductalcarcinomainsitu的作为一个预示的因素的组织学的分级的意义：根据凡·奈鈥檚分类，胸的ductalcarcinomainsitu(DCIS)的32个盒子被划分成三个组。结果：低等级(很好区分的、低等级DCIS)12个病人(37.5%)；中间的等级，9个病人(28.1%)；高等级(糟糕区分的DCIS)11个病人(34.4%)。在高等级DCIS之中，histologic子类型是粉刺(9个病人)，micropapillary(1个病人)和固体(1个病人)。在高等级DCIS的积极表示ofc-erbB-2，p53和MIB-1在中间、低的等级DCIS比那高。高等级和低等级DCIS之间的差别是重要的(P<0.05)。表示嗯在高等级，DCIS在中间、低的等级DCIS是比那低的。结论：胸ductalcarcinomainsitu的组织学的分级可以是一个好预示的因素。

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简介：Breastcanceristhemostprevalentfemalecancerinboththedevelopedandlessdevelopedworld.AccordingtoWHO2013estimates,therewereover522000femalebreastcancerdeathsin2012[1].Breastcancer(1.7million)wasthesecondcommonlydiagnosedcancerworldwideafterlungcancer(1.8million),andfollowedbycolorectalcancer(1.4million)[1].Inless

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