简介：AbstractThere are only a few case reports of Q fever caused by Coxiella burnetii in China, despite the nature as a ubiquitous zoonotic disease worldwide. In the northeast part of China, a 52-year-old male presented with fever, cough, shortness of breath, and sputum production, accompanied by headache, dizziness, chill, myalgia, and arthralgia. Chest computed tomography images showed pneumonia accompanied by bilateral scattered infiltrates and localized upper-lobe emphysema. The abnormal liver function was indicated by the increased levels of alanine aminotransferase and aspartate aminotransferase. Through high-throughput sequencing and molecular detection, Coxiella burnetii was positive in the patient's blood specimens. After treatment with moxifloxacin hydrochloride and vidarabine monophosphate for 12 days, the patient completely recovered. To our knowledge, this was the first reported case of Q fever with pneumonia and hepatitis in this country.

简介：Theinitialassessmentoftravellersisaimedprimarilyatearlydetectionandtreatmentofmalaria(seepage32),whichcanberapidlyfatal.

简介：AcuterheumaticfeverisinitiatedbygroupAstreptococcalphar-yngitis.Thisisfollowedbyalatentperiodof2-6weeks,afterwhichtheclinicalsyndromeofacuterheumaticfeverevolves,characterizedbypolyarthritis,carditis,chorea,erythemamarginatumandsubcutaneousnodules.Thesefeaturesmayoccursinglyorinanycombination.

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简介：Thesurvivalorientedadaptationofevolvedbiosystemstovariationsintheirenvironmentisaselectiveoptimizationprocess.Recognizingtheoptimisedendproductanditsfunctionalityistheclassicalarenaofbionicengineering.Inaprimordialworld,however,themolecularorganizationandfunctionsofprebioticsystemsweresolelydefinedbyformativeprocessesintheirphysicalandchemicalenvironment,forinstance,theinterplaybetweeninterfacialwaterlayersonsurfacesandsolarlight.Theformativepotentialoftheinterplaybetweenlight(laserlight)andinterfacialwaterlayersonsurfaceswasrecentlyexploitedintheformationofsupercubanecarbonnanocrystals.Inevolvedbiosystemstheformativepotentialofinterfacialwaterlayerscanstillbeactivatedbylight.Herewereportacaseofhayfever,whichwassuccessfullytreatedinthecourseofafacialreju-venationprogramstartinginNovember2007.Targetingprimarilyinterfacialwaterlayersonelastinfibresinthewrinkledareas,wepresumablyalsoactivatedmastcellsinthenasalmucosa,reportedtoprogressivelydecreaseinthenasalmucosaoftherabbit,whenfrequentlyirradiated.Hayfeverisinducedbythereleaseofmediators,especiallyhistamine,aprocessassociatedwiththedegranulationofmastcells.Decreaseinmastcellsnumbersimpliesadecreaseinthereleaseofhistamine.Tothebestofourknowledgethisisthefirstreportonthetreatmentofhayfeverwithvisiblelight.Thisapproachwasinspiredbybionicthinking,andcouldhelpamelioratingtheconditionofmillionsofpeoplesufferingfromhayfeverworldwide.

简介：Oncomelania(Oncomelaniahupensis),adioecian,ovoviviparous,andamphibioussnail,isthesoleintermediatehostofSchistosomajaponicum,themostwide-spreadsnailfeverintheworld.Chemicaleliminatingthehostprovedunacceptablefortherewasseverecontaminationtowaterandsoil.TheriverbeachesandthedeltaareasoffiveprovincesinthemiddleandlowerreachesofYangtzeRiverinChinaprovidethemostfavorablehabitatsforOncomelania.Ourstudieshaverevealedthattheoccurrenceof...

简介：2CasesofMediterraneanspottedfeverinFrancewerereportedinthispaper.Bothhadtraveledintheendemicareasbeforeonset.Theirclinicalmanifestationsincludedfever,headache,myalgia,eruptionandblackeschar.SerologictestssuchasWeil-Felixreaction,Indirectimmunoflurescenceandcomplementfixationconfirmedthediagnosis.Thepatientsrecoveredwithoutcomplicationsandweredischargedfromhospitalaftereffectivetreatment.Simultaneously,theepidemiology,clinicaldiagnosis,treatmentandpreventionofthediseasewerereviewedandthepossibilityofthediseasebeingintroducedintothisterritorywasdiscussed.Theauthorheldthatattentionshouldbepaidtotheprophylaxisandtreatmentofthediseaseintheinternationaltravelhealthcare.

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简介：AbstractPeriodic fever, aphthous stomatitis, pharyngitis, and adenitis (PFAPA) syndrome is the most common periodic fever condition in children, with most cases appearing by the age of 5. Although PFAPA is generally a self-limited condition, it can have a major impact on a child’s quality of life, as well as that of their family. Recent research has continued to shed light on the genetic and immunologic factors that play a role in the pathogenesis of PFAPA. There also exists significant heterogeneity in treatment strategies, and progress has been made to develop evidence-based management strategies and establish a standard of care. This review will outline current knowledge regarding the pathogenesis of PFAPA, as well as treatment strategies and our clinical experience.

简介：Q：为什么水能浇灭火？A：这个问题看起来是不是很简单？但是，把它答错的人却不在少数哦。水究竟对火起了什么作用，让火熄灭的呢？

简介：谷口侦探说话时,监识课员正在忙着取角度,准备把“Q”字拍照存证。等相片拍好,谷口便拿出薄刀,小心谨慎地从墙上刮下一些蓝色粉笔灰。这时候,玉置刑警拿起歹徒遗留在现场的一顶沾有血迹的软帽,仔细地端详。

简介：Inordertoanalyzethenucleoprotein(NP)geneofCrimean-Congohemorrhagicfevervirus(CCHFV),viralRNAwasamplifiedbyRT-PCRbyusingtheproof-readingDNApolymerasetoproducethecompleteNPgene.ThePCRproductwassequenced,analyzedforphylogenesisandclonedintotheexpressionvectorpE132aandtherecombinantplasmidexpressedinE.coilBL-21withhighyield.Theprimarilypurifiedfusedprotein.wasusedtocoatELISAplatesforthedetectantibodies.ItwasfoundthesimilaritiesbetweenNPgeneofBA88166andotherXHFVsinnucleotidelevelandaminoacidcontentswereverysignificant,andtheNPgeneofBA88166encodedanucleoproteinwith482aminoacidandadeducedmolecularweight(MW)of54kDa.Westernblotassayshowedthatthefusionproteinexpressedinbacteriapossessedgoodantigenicity.TheresultswithELISAforthedetectionofthehumanandanimalseracollectedinendemicareaswerefoundtobeingoodaccordancetotheclinicaldiagnosis.ItconcludedthattherelationsofNPgenesofXHFVBA88166andotherXHFVsappearedtobeevolutionallyclose.Themethodologiesestablishedinthisstudywereaccurate,specific,rapidandreproduciblefortheclinicalexaminationsandepidemiologicalsurvey.

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简介：AbstractSevere fever with thrombocytopenia syndrome (SFTS) was first detected in China in 2009. The incidence of SFTS increases year by year, and there is no effective treatment. Considering that the reported prevalence of SFTSV infection varies from region to region, we aimed to quantitatively evaluate the epidemic characteristics of SFTSV infection in China from 2010 to 2020, including the distribution differences in infectious season, sex, age, occupation, and region. A meta-analysis framework was used to search for the related published data with keywords in electronic databases (CNKI, WanFang, CBM, and PubMed). According to the PRISMA statement, the studies that included SFTS diagnosed in China were analyzed. Furthermore, we used Revman and Stata to merge statistical effects, and used I2 and P-values for heterogeneity test and quality assessment. Eleven studies containing 4,932 cases confirmed by SFTSV infection were included in this meta-analysis. The ratio of male-to-female is 1.04 to 1. Cases were concentrated between 40 and 80 years of age (MD = 92%, 95%CI: 91%-93%). Farmers are at the highest risk of SFTSV infection (MD = 84%, 95%CI: 77%-90%). The risk of infection for consecutive period of April-August was significantly higher than the sum of the remaining months (MD = 82%, 95%CI: 78%-85%). In addition, the patient has an extensive history of exposure, including living in the mountains, exposure to ticks, livestock, mouse and the patient. We came to the conclusion that SFTSV is transmitted primarily through tick bites in China, so middle-aged and older adults living in mountains regions are at the highest risk for SFTSV infection in April through August each year.

简介：AbstractPurpose:There are many infectious and inflammatory causes for elevated core-body temperatures, though they rarely pass 40 ℃ (104 ℉). The term "quad fever" is used for extreme hyperpyrexia in the setting of acute cervical spinal cord injuries (SCIs). The traditional methods of treating hyperpyrexia are often ineffective and reported morbidity and mortality rates approach 100%. This study aims to identify the incidence of elevated temperatures in SCIs at our institution and assess the effectiveness of using a non-invasive dry water temperature management system as a treatment modality with mortality.Methods:A retrospective analysis of acute SCI patients requiring surgical intensive care unit admission who experienced fevers ≥ 40 ℃ (104 ℉) were compared to patients with maximum temperatures < 40 ℃. Patients ≥18 years old who sustained an acute traumatic SCI were included in this study. Patients who expired in the emergency department; had a SCI without radiologic abnormality; had neuropraxia; were admitted to any location other than the surgical intensive care unit; or had positive blood cultures were excluded. SAS 9.4 was used to conduct statistical analysis.Results:Over the 9-year study period, 35 patients were admitted to the surgical intensive care unit with a verified SCI. Seven patients experienced maximum temperatures of ≥ 40 ℃. Six of those patients were treated with the dry water temperature management system with an overall mortality of 57.1% in this subgroup. The mortality rate for the 28 patients who experienced a maximum temperature of ≤ 40 ℃ was 21.4% (p = 0.16).Conclusion:The diagnosis of quad fever should be considered in patients with cervical SCI in the presence of hyperthermia. In this study, there was no significant difference in mortality between quad fever patients treated with a dry water temperature management system versus SCI patients without quad fever. The early use of a dry water temperature management system appears to decrease the mortality rate of quad fever.

简介：该句貌似宾语从句，其实是一种复合特殊疑问句。这种疑问句的特点是疑问词在句首，doyouthink作为插入语放句中，形成“疑问词＋dovouthink＋陈述句”的句型。疑问词可以是疑问代词或疑问副词。若是疑问代词，可作doyouthink后面句子的主语或宾语，若是疑问副词．则作后面句子的状语。如：

简介：<正>Q:请问瘦人想练得壮些,吃东西注意些什么?A:蛋白质是肌肉增长最重要的营养源,健美训练者蛋白质的摄人应以非脂或低脂食品为主,如脱脂牛奶、蛋清、鱼、去皮家禽、牛排等,瘦人可以适当的增加高热量的碳水化合物和脂肪的摄入。只有摄入的能量大于消耗的能量,人才能变壮。因此,消瘦者的膳食调配一定要合理、多样,不可偏食。平时除食用富含动物性蛋白质的肉、蛋、禽类等,碳水化合物也是重要部分,还要适当多吃一些豆制品及赤豆、百合、蔬菜、瓜果等。蛋白质,碳水化合物,脂肪三种主要营养素的比例应为:40%:40%:20%只要饮食营养全面,利于消化吸收,再加上适当的健美锻炼,就能在较短时间内变得健壮起来。

简介：<正>司老师:我是一个下尚女工,今年45岁。我爱人是一个即将下岗的司机,孩子刚上高中。我们全家的收入不过千八百元,日子过得十分拮据。可以说,我从跟他结婚那一天起就没过过好日子。他是一个只会开车的男人,根本就没有上进心。眼看就要下岗了,我劝他另想门路,可他只会抽烟、喝闷酒,家里的事他什么都不管。

简介：<正>司老师:我是一个小学五年级孩子的母亲,也是一个从来没有尝过爱情滋味的女人。我是从农村走出来的,为了摆脱那种“面朝黄土背朝天”的日子．我发愤读书．考上了大学．在一个中等城市里找到了一份工作。因为家庭境况不好,谈恋爱也没有底气,对想爱的人不敢表白．而爱我的人我又看不上。最后,我委曲求全地嫁给一个有房子、经济条件相对不错的城里男人。