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简介：CaiFangwasborninSeptember1956inBeijing.HegraduatedinRenminUniversityofChinaandthengothisdoctorateineconomicsfromtheGraduateSchoolofChinaAcademyofSocialSciences(CASS).Now,heisCASSAcademicCommitteeMemberandDirectorGeneralofInstituteofPopulationandLabourEconomics.In1998,hereceivedthenationaltitleofYoungExpertwithOutstanding

简介：ObjectiveTostudytheinfluenceofJiangTangFangLongformulaoninsulinproductionandfunctioninananimalmodelofdiabetichearingloss.MethodsWistarrats(n=60)wererandomlydividedinto6groups(10ineach)toreceivenotreatment(thenormalcontrol,GroupA),ortoreceiveintra-peritoneal55mg/kgstreptozotocinwith(GroupsC,DandE)orwithout(GroupB)subsequentJiangTangFangLongformulatreatmentatvariousdosesorYuLongWantreatment(GroupF).After60days,fastingbloodglucose(FBG),bodyweight(BW)andfastinginsulin(FINS)wererecordedandtheHOMA-IRandHOMA-βcalcu-lated.Insulinexpressioninpancreatictissueswasmeasuredbyradioimmunoassay.ResultsComparedwithanimalsthatreceivedstreptozotocinwithoutrescuetreatment(GroupB),animalsthatreceivedhigherdosesofJiangTangFangLongformula(GroupsDandE)showedimprovedindicesofdiabetesmanifestation(P<0.05)andimprovedHOMA-β(P<0.05)inadose-dependentmanner,aswellasimprovedinsulinexpressioninpancreaticislets(P<0.05).ThedifferencebetweenlowdoseJiangTangFangLongformulatreatment(GroupC)andGroupBwasnotsignificant(P>0.05).ConclusionOurresultssuggestthatJiangTangFangLongformulamayimprovepancreaticβ-cellsfunctionwhichmayexplainitsefficacyintreatingdiabetichearingloss.

简介：ObjectiveTostudytheefficacyandsafetyoftheJiangTangFangLongJiaoNang(HypoglycemicAnti-DeafnessCapsule)intreatingnon-insulindependentdiabetesmellituswithhearingloss.MethodsTwohundredninetysixpatientswithnon-insulindependentdiabetesmellitusandhearinglosswererandomlyassignedtoatreatmentgroup(n=164,208ears)andacontrolgroup(n=132,184ears).PatientsinthetreatmentgroupweretreatedwiththeJiangTangFangLongJiaoNangandsupplementherbalpreparationsasindicatedbytraditionalChinesemedicinedialecticalassessment,whilecontrolpatientsreceivedglibenclamideandconventionaltreatmentsfordeafness.Hearing,fastingbloodglucose(FBG),post-prandialbloodglucose(PBG),24hoururinesugar,plateletfunctionindices,bloodsuperoxidedismutase(SOD)andlipidperoxides(LPO)levels,andsymptomimprovementwerecomparedbetweenthetwogroups.ResultsTherateofhearingimprovementwas56.7%forthetreatmentgroupand26.6%forthecontrol.FBG,PBGand24hoururinesugarimprovedinbothgroups,butthelasttwoweresuperiorinthetreatmentgroupcomparedtothecontrol.Symptomsimprovementwasalsosuperiorinthetreatmentgroupcomparedtothecontrol.InpatientsreceivingJiangTangFangLongJiaoNangtreatment,plateletfunctionindices,SODandLPOwereallimproved,whileonlyLOPimprovementwasnoticedincontrolpatients.Noacuteorlong-termtoxicitywasdemonstratedfortheJiangTangFangLongJiaoNanginanimaltests.TheJiangTangFangLongJiaoNangloweredbloodglucoseandserumtriglyceridesinaratmodelofalloxan-induceddiabetes.ConclusionTheJiangTangFangLongJiaoNangiseffectiveinimprovinghearinganddiabeticindicesindiabeticpatientswithdeafness,withoutsignificantsideeffects.

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