简介：有三种不同尖端清理尺寸的尖端清理流动的摇摆数字地在这篇论文被调查。NASA转子67被选择为计算模型。尖端清理的尺寸什么时候等于，被发现在所有模仿的案例之中，摇摆存在或比设计尖端清理尺寸大。相对全部的压力系数轮廓显示由尖端漏流动的影响的那个区域以固定集体流动率随尖端清理尺寸的增加扩充。在转子尖端区域的静态的压力分发的根吝啬的方形的轮廓被提供为设计尖端清理(1.1%尖端弦)说明那最强壮的波动区域在前缘附近位于片的压力方面，当时为更大的尖端清理(2.2%尖端弦)，它在在冲击波和尖端漏流动之间的相互作用的区域。

简介：Aseriesofmodifiedpoly(methylmethacrylate,PMMA)resinswerepreparedandcomparedtheiradsorptionabilitiestoendotoxin.Theresultsshowedthatadsorbents,whichweregraftedwithtertiaryamineandlongspacingarms,hadthebestadsorptioncapacitiesandgoodbloodcompatibility,Itishopefultobeusedasadsorbentinhemoperfusionforclinicalclearanceofendotoxin.Theinfluenceoforiginalconcentrationofendotoxinonadsorptionandtheadsorptionmechanismwerealsoinvestigated.

简介：CantonFairtoopeninOctober,exhibitionboothsremain55,000Theexhibitionboothswillremain55thousand,thesameaslastsession,inthethreefive-dayphases.Theintervalforboothsetupwillbeshortenedfrom4daysto3days,andtheclosingtimeofeachdayisscheduledto6pm.

简介：Ⅰ.Characteristicofthesupervisionmodeof'LocalDeclaration&PortClearance'Thisnewmodemeansthattheconsignor,consigneeoragent(hereafterreferredtoas'declarant')couldchooseanycompetentcustomsunderthejurisdictionofGuangzhouCustomstomakedeclarationandgothroughtheformalitiesofdocument-checkingandduty-paying,andthenfinishthecargo-exam-

简介：Inthispaper,a3Dsourcedistributiontechniqueisusedtocalculatethecoupledmotionsbetweentwoshipswhichadvanceinthewavewiththesamespeed.Thenumericalresultsofcoupledmotionsforafrigateandasupplyshiphaveagoodagreementwiththeexperimentalresults.Basedonthe3Dcoupledmotionsoftwoships,aspectralanalysisisemployedtoclearlyobservetheeffectofspeed,clearanceandwaveheadingonthesignificantrelativemotionamplitude(SRMA)oftwoships.Themethodpresentedinthispaperwillbehelpfultoselectsuitableclearance,speedandwaveheadingforunderwayreplenishmentatsea(RAS).

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简介：Defectsinkinematicjointscansometimeshighlyinfluencethesimulationresponseofthewholemultibodysystemwithinwhichthesejointsareincluded.Forinstance,theclearance,thefriction,thelubricationandtheflexibilityaffectthetransientbehaviour,reducethecomponentlifeandproducenoiseandvibrationforclassicaljointssuchasprismatics,cylindricsoruniversaljoints.Inthiswork,anew3Dcylindricaljointmodelwhichaccountsfortheclearance,themisalignmentandthefrictionispresented.Thisformulationhasbeenusedtorepresentthelinkbetweentheplanetgearsandtheplanetcarrierinanautomotivedifferentialmodel.

简介：Bymeansofinktracevisualizationandtopologicalanalysis,thispaperinvestigatesthetopologicalstructureoftheflowpatternsurrondingbothendwallsandbladesurfacesforalowaspectratiolinearrotorcascadewithtipclearance.Thestructureoftheflowpatternshowsthatmostofthesingularpointandseparationlinesarelocatedintheupperhalfspanregionofthetestedcascadewheretheaerodynamicbehaviorsaredeteriorated.

简介：Stabilityanddynamiccharacteristicsofaballbearing-rotorsystemareinvestigatedundertheeffectoftheclearanceintheballbearing.DifferentclearancevaluesareassumedtocalculatethenonlinearstabilityofperiodicsolutionwiththeaidoftheFloquettheory.Bifurcationandchaosbehaviorareanalyzedwithvariationoftheclearanceandrotationalspeed.Itisfoundthattherearethreeroutestounstableperiodicsolution.Theperiod-doublingbifurcationandthesecondaryHopfbifurcationaretwousualroutestoinstability.Thethirdrouteistheboundarycrisis,achaoticattractoroccurssuddenlyasthespeedpassesthroughitscriticalvalue.Atlast,theinstablerangesfordifferentinternalclearancevaluesaredescribed.Itisusefultoinvestigatethestabilitypropertyofballbearingrotorsystem.

简介：AbstractBackground:A patient’s infectivity is determined by the presence of the virus in different body fluids, secretions, and excreta. The persistence and clearance of viral RNA from different specimens of patients with 2019 novel coronavirus disease (COVID-19) remain unclear. This study analyzed the clearance time and factors influencing 2019 novel coronavirus (2019-nCoV) RNA in different samples from patients with COVID-19, providing further evidence to improve the management of patients during convalescence.Methods:The clinical data and laboratory test results of convalescent patients with COVID-19 who were admitted to from January 20, 2020 to February 10, 2020 were collected retrospectively. The reverse transcription polymerase chain reaction (RT-PCR) results for patients’ oropharyngeal swab, stool, urine, and serum samples were collected and analyzed. Convalescent patients refer to recovered non-febrile patients without respiratory symptoms who had two successive (minimum 24 h sampling interval) negative RT-PCR results for viral RNA from oropharyngeal swabs. The effects of cluster of differentiation 4 (CD4)+ T lymphocytes, inflammatory indicators, and glucocorticoid treatment on viral nucleic acid clearance were analyzed.Results:In the 292 confirmed cases, 66 patients recovered after treatment and were included in our study. In total, 28 (42.4%) women and 38 men (57.6%) with a median age of 44.0 (34.0-62.0) years were analyzed. After in-hospital treatment, patients’ inflammatory indicators decreased with improved clinical condition. The median time from the onset of symptoms to first negative RT-PCR results for oropharyngeal swabs in convalescent patients was 9.5 (6.0-11.0) days. By February 10, 2020, 11 convalescent patients (16.7%) still tested positive for viral RNA from stool specimens and the other 55 patients’ stool specimens were negative for 2019-nCoV following a median duration of 11.0 (9.0-16.0) days after symptom onset. Among these 55 patients, 43 had a longer duration until stool specimens were negative for viral RNA than for throat swabs, with a median delay of 2.0 (1.0-4.0) days. Results for only four (6.9%) urine samples were positive for viral nucleic acid out of 58 cases; viral RNA was still present in three patients’ urine specimens after throat swabs were negative. Using a multiple linear regression model (F = 2.669, P = 0.044, and adjusted R2 = 0.122), the analysis showed that the CD4+ T lymphocyte count may help predict the duration of viral RNA detection in patients’ stools (t = -2.699, P = 0.010). The duration of viral RNA detection from oropharyngeal swabs and fecal samples in the glucocorticoid treatment group was longer than that in the non-glucocorticoid treatment group (15 days vs. 8.0 days, respectively; t= 2.550, P = 0.013) and the duration of viral RNA detection in fecal samples in the glucocorticoid treatment group was longer than that in the non-glucocorticoid treatment group (20 days vs. 11 days, respectively; t = 4.631, P < 0.001). There was no statistically significant difference in inflammatory indicators between patients with positive fecal viral RNA test results and those with negative results (P > 0.05).Conclusions:In brief, as the clearance of viral RNA in patients’ stools was delayed compared to that in oropharyngeal swabs, it is important to identify viral RNA in feces during convalescence. Because of the delayed clearance of viral RNA in the glucocorticoid treatment group, glucocorticoids are not recommended in the treatment of COVID-19, especially for mild disease. The duration of RNA detection may relate to host cell immunity.

简介：在这研究，一件涡轮充电器的离心压气机试验性地并且数字地被调查。压缩机的表演特征被转子速度和流动参数的大小在压缩机的入口和插头试验性地获得。在impeller的三个维的流动领域并且更弥漫与SST骚乱用一个完整的海军司烧节目数字地被分析模型。压缩机的表演特征数字地被获得，它当时与试验性的结果相比。比较显示出好同意。而且，区域比率的效果和性能参数和流动地上的尖端清理数字地被学习。impeller区域比率被切impeller出口轴改变从到5.1公里的最后的价值的4.1公里的起始的价值的宽度，从0.792～0.965导致区域比率。为有出口的转子4.6公里的轴的宽度，性能为0.0，0.5和1.0公里的尖端清理被调查。当效率在0.878的区域比率的更高的价值达到顶点时，在设计点的这模拟的结果证明压缩机压力比率在0.792的区域比率达到顶点。另外，从0～1公里的尖端清理的增长导致了20%效率减少。

简介：基于小浪包转变(WPT)，基因算法(GA)，神经网络(BPNN)和支持向量用机器制造的背繁殖(SVM)，柴油机引擎阀门清理的一个差错诊断方法被介绍。与力量光谱密度分析，与运用条件的引擎有关的典型频率能从颤动信号被提取。小浪系数和根的最大的单个值(BSV)意味着在典型频率亚乐队的颤动的平方(RMS)值在颤动信号的第三水平分解的目的被提取，并且他们被用作BPNN或SVM的输入向量。为了避免，在本地最小被套住，GA被采用。正常和处于不同阀门清理条件测量的差错颤动信号被分析。BPNN，GA背繁殖神经网络(GA-BPNN)，SVM和GA-SVM被用于为不同特征的抽取训练并且测试，并且分类精确性和训练时间与相比决定最佳差错分类器和特征选择。试验性的结果证明建议特征和分类算法给100%的分类精确性。

简介：Toclarifytheinfluencesofthetipclearanceflowsontheunsteadycavitatingflow,thethree-dimensionalunsteadycavitatingflowsthroughboththetwo-dimensionalcascadesandthethree-dimensionalinducerwithandwithouttipclearanceareperformednumerically.ThegoverningequationsforthecompressiblefluidflowwiththeDESturbulencemodelareemployedwiththeassumptionoftheisentropicprocessofliquidphase.Theevolutionofcavitiesisrepresentedasthesource/sinkofvaporphase.Thebasicequationsinthecurvelinearcoordinatearesolvedbythefinitedifferencemethod.Astheresultsofthethree-dimensionalcavitatingflowsthroughthetwo-dimensionalcascades,thetipclearanceflowsfromthepressuresidetothesuctionsideofthebladeproducesthetipvortexcavitation,whichaffectsthesheetcavitationontheleadingedgeofthenextbladeandenhancestheblockageeffectnearthecasingthantheflowswithouttipclearance.Ontheotherhand,inthecaseofthethree-dimensionalinducer,thelargebackflowcavitationisobservedaroundtheinletoftheinducer,wherethecavitiesaredevelopedonthecasingbythetipclearanceflows.Thelargepressuregradientbetweenthenon-cavitatingpressuresideandthecavitatingsuctionsideenhancesthetipclearanceflows.Thecalculationconsideringthetipclearancereproducesthedevelopedcavitationregionsimilartothatofexperimentalvisualizations.Additionally,thebackflowcavitationrotateswiththespeedslowerthantherotationspeedoftheinducer.Then,therotationofbackflowcavitationcausestheperiodicfluctuationoftheoutletpressuregreaterthanthatoftheinletpressure.

简介：Objective:Impairedactivefluidtransportofalveolarepitheliummayinvolveinthepathogenesisandresolutionofalveolaredema.Thcobjectiveofthisstudywastoexplorethechangesinalveolarepithelialliquidclearanceduringlungedemafollowingacutelunginjuryinducedbyoleicacid.Methods:Forty-eightWistarratswererandomlydividedintosixgroups,I.e.,injured,amiloride,ouabain,amilorideplusouabainandterbutalinegroups.Twenty-fourhoursaftertheinductionofacutelunginjurybyintravenousoleicacid(0.25ml/kg),5％albuminsolutionwith1.5μCi125Ⅰ-labeledalbumin(5ml/kg)wasdeliveredintobothlungsviatrachea.Alveolarliquidclearance(ALC),extravascularlungwater(EVLW)contentandarterialbloodgasesweremeasuredonehourthereafter.Results:At24haftertheinfusionofoleicacid,theratsdevelopedpulmonaryedemaandseverehypoxemia,withEVLWincreasedby47.9％andALCdecreasedby49.2％.Additionofeither2×10-3Mamilorideor5×10-4MouabaintotheinstillationfurtherreducedALCandincreasedEVLW.ALCincreasedbyapproximately63.7％andEVLWdecreasedby46.9％withimprovedhypoxemiaintheTerbutaline(10-4M)group,comparedthoseininjuredrats.AsignificantnegativecorrelationwasfoundbetweentheincrementofEVLWandthereductionofALC.Onclusions:Activefluidtransportofalveolarepitheliummightplayaroleinthepathogenesisoflungedemainacutelunginjury.

简介：AbstractBackground:The efficacy of hemodialysis (HD) is closely associated with patient survival time and quality of life. The classical method (CLM) to calculate the urea clearance index (Kt/V) and urea reduction rate (URR) requires multiple blood tests. A novel method that may be used as a noninvasive alternative to CLM is required.Methods:Based on the urea kinetic model, a new method, named the "assessment method" (ASM), was established to calculate blood urea nitrogen after HD, based on parameters obtained during HD. The consistency of the Kt/V and URR values between the ASM and CLM was evaluated in 41 patients from the China-Japan Friendship Hospital between September 2017 and December 2018.Results:Forty-one patients (24 males and 17 females; mean age, 55.7 ± 14.2 years) undergoing regular HD in our hospital were randomly selected for this study. The blood flow rate was 244.5 ± 19.6 mL/min and the dialysate flow rate was 500 mL/min. We obtained Kt/V (CLM = 1.40 ± 0.06, ASM = 1.37 ± 0.07) and URR (CLM = 68.6 ± 6.4%, ASM = 67.7 ± 7.2%) values. Paired t-test indicated no significant differences between the ASM- and CLM-derived values. The intraclass correlation coefficients were 0.907 and 0.916 for Kt/V and URR, respectively. Similarly, Bland-Altman plots suggested good concordance between the 2 methods.Conclusions:The Kt/V and URR values calculated using the ASM and CLM were in significant agreement, and both can be used to effectively assess the adequacy of HD in patients undergoing maintenance HD. The ASM is an effective, rapid, inexpensive, and noninvasive alternative to the CLM for obtaining Kt/V and URR values. The ASM has good potential for clinical application, particularly for patients in areas of low socioeconomic status.

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简介：ThisstudydevelopedapopulationpharmacokineticmodelforsodiumtanshinoneIIAsulfonate(STS)inhealthyvolunteersandcoronaryheartdisease(CHD)patientsinordertoidentifysignificantcovariatesforthepharmacokineticsofSTS.Bloodsampleswereobtainedbyintensesamplingapproachfrom10healthyvolunteersandsparsesamplingfrom25CHDpatients,andapopulationpharmacokineticanalysiswasperformedbynonlinearmixed-effectmodeling.Thefinalmodelwasevaluatedbybootstrapandvisualpredictivecheck.Atotalof230plasmaconcentrationswereincluded,137fromhealthyvolunteersand93fromCHDpatients.Itwasatwo-compartmentmodelwithfirst-orderelimination.Thetypicalvalueoftheapparentclearance(CL)ofSTSinCHDpatientswithtotalbilirubin(TBIL)levelof10μmol(L?1was48.7L(h?1withinterindividualvariabilityof27.4%,whereasthatinhealthyvolunteerswiththesameTBILlevelwas63.1L(h?1.Residualvariabilitywasdescribedbyaproportionalerrormodelandestimatedat5.2%.TheCLofSTSinCHDpatientswaslowerthanthatinhealthyvolunteersanddecreasedwhenTBILlevelsincreased.Thebootstrapandvisualpredictivecheckconfirmedthestabilityandvalidityofthefinalmodel.TheseresultssuggestedthatSTSdosageadjustmentmightbeconsideredbasedonTBILlevelsinCHDpatients.