简介：研究观察年龄对潘库溴铵药代动力学的影响。选择２４例施择期整形外科手术的患者，根据年龄分成三组：１组为５例婴幼儿，年龄０．７５～２．９５岁；２组为１３例儿童，年龄４～１４岁；３组为６例成人，年龄１６～２７岁。静注潘库溴铵１００μｇ／ｋｇ后用改良荧光法测定其血浓度。潘库溴铵的体内过程能用二室开放模型完整描述，年龄愈小，分布容积愈大，血浆清除率愈高，潘库溴铵的血药浓度愈低。Ｖ１（中央室分布容积）、Ｖ２（周边室分布容积）、Ｖｄｓｓ（稳态分布容积）、Ｃｌ（血浆清除率）和ＡＵＣ（曲线下面积）在三组间有明显差别。１组的Ｔ１／２β和ＭＲＴ明显比２、３组长，但Ｔ１／２α和Ｋ２１在三组间无明显差别。

简介：BackgroundCongenitaltrachealstenosis(CTS)isachallengingairwayproblem.CTSininfantsandchildrencanbelife-threatening.Duringlastthirtyyears,alargenumberofstudiescoveringthediagnosis,clinicalpresentation,managements,especiallysurgicaltreatmentsofCTShavebeenreported.ThisreviewaimedtoconcluderecognizedknowledgeofCTSandprovidecluesformanaginginfantsandchildrenwithCTS.

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简介：Inthispaper,afacialfeatureextractingmethodisproposedtotransformthree-dimension(3D)headimagesofinfantswithdeformationalplagiocephalyforassessmentofasymmetry.Thefeaturesof3Dpointcloudsofaninfant’scraniumcanbeidentifiedbylocalfeatureanalysisandatwo-phasek-meansclassificationalgorithm.The3Dimagesofinfantswithasymmetriccraniumcanthenbealignedtothesamepose.Themirroredheadmodelobtainedfromthesymmetryplaneiscomparedwiththeoriginalmodelforthemeasurementofasymmetry.Numericaldataofthecranialvolumecanbereviewedbyapediatriciantoadjustthetreatmentplan.Thesystemcanalsobeusedtodemonstratethetreatmentprogress.

简介：ＡｎＩｎｔｅｒｖｉｅｗｗｉｔｈＬｉＹｉｎｉｎｇＯｎＪａｎｕａｒｙ１７，１９９４，ｏｕｒｒｅｐｏｒｔｅｒｉｎｔｅｒｖｉｅｗｅｄＭｒＬｉＹｉｎｉｎｇ，ｗｅｌｌ－ｋｎｏｗｎｐｒｏｆｅｓｓｏｒｏｆｅｃｏｎｏｍｉｃｓ，ｍｅｍｂｅｒｏｆｔｈｅＳｔａｎｄｉｎｇＣｏ...

简介：OBJECTIVE:Ameta-analysisofpublishedrandomizedcontrolledtrialsinvestigatingthelongtermeffectofdexamethasoneonthenervoussystemofpreterminfants.DATASOURCES:OnlineliteratureretrievalwasconductedusingTheCochraneLibrary(fromJanuary1993toJune2013),EMBASE(fromJanuary1980toJune2013),MEDLINE(fromJanuary1963toJune2013),OVID(fromJanuary1993toJune2013),Springer(fromJanuary1994toJune2013)andChineseAcademicJournalFull-textDatabase(fromJanuary1994toJune2013).KeywordswerepreterminfantsanddexamethasoneinEnglishandChinese.STUDYSELECTION:Selectedstudieswererandomizedcontrolledtrialsassessingtheeffectofintravenousdexamethasoneinpreterminfants.Thequalityoftheincludedpaperswasevaluatedandthosewithoutthedevelopmentofthenervoussystemandanimalexperimentswereexcluded.QualityassessmentwasperformedthroughbiasriskevaluationinaccordancewithCochraneHandbook5.1.0softwareintheCochraneCollaboration.ThehomogeneousstudieswereanalyzedandcomparedusingRevman5.2.6software,andtheneffectmodelwasselectedandanalyzed.Thosepapersfailedtobeincludedinthemeta-analysisweresubjectedtodescriptiveanalysis.MAINOUTCOMEMEASURES:Nervoussysteminjuryinpreterminfants.RESULTS:Tenrandomizedcontrolledtrialswerescreened,involving1,038subjects.Amongthem512casesreceiveddexamethasonetreatmentwhile526casesservedasplacebocontrolgroupandblankcontrolgroup.Meta-analysisresultsshowedthattheincidenceofcerebralpalsy,visualimpairmentandhearinglossinpreterminfantsafterdexamethasonetreatmentwithin7daysafterbirthwassimilartothatinthecontrolgroup(RR=1.47,95%CI:0.97–2.21;RR=1.46,95%CI:0.97–2.20;RR=0.80,95%CI:0.54–1.18;P>0.05),butintelligencequotientwassignificantlydecreasedcomparedwiththecontrolgroup(MD=-3.55,95%CI:-6.59to-0.51;P=0.02).Preterminfantstreatedwithdexamethasone7daysafterbirthdemonstratedaninci

简介：运用推拿手法治疗婴幼儿肌性抖颈33例，并观察治疗前后患侧胸锁乳突肌包块的B超影像的变化。结果痊愈27例，有效5例，无效1例，总有效率97．0％；B超影像显示，患侧颈部可探及梭型或卵圆形包块．呈低回声者28例，中等回声者2例，高回声者3例。治疗前后包块的长度、厚度和宽度均有明显差异，P<0．017表明推拿治疗小儿肌性斜颈疗效著；超声检查可作为推拿治疗过程中评价治疗效果的一种客观标准，是一种简捷、方便、又经济的检查方法，有利于一临床推广。

简介：Boers-Li画廊的迅速成长毫无疑问与老板皮力有着直接的关系,皮力有着多重身份：博士、批评家、中国最顶尖的艺术策展人之一、中央美院艺术管理系老师。2005年,策展人皮力与WalingBoers在草场地共同创办了UniversalStudiosbeijing,其后更名为Boers-Li画廊。

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简介：ObjectivesToexplorethefeasibility,necessity,andsecurityoftranscatheterclosureofpatentductusarteriosus(PDA)ininfants.MethodsTherewere230infantswithPDA.Theageswere(7.3±3.2)monthsandtheweight(6.6±2.8)Kginaverage.Theywereseparatedintotwogroups.GroupAwasformedbytheinfantsweighinglessthan6Kg,GroupBover6Kg.RightheartcatheterizationwasperformedfirsttocalculatetheratioofQp/Qs.ThendescendingaortographydemonstratedthediameterandshapeofPDA.Properoccluderwasselectedtofinishtheintervention.Echocardiographywasperformedafterintervention24hoursand1,3,6,12and24months.ResultsInGroupAthetechnicalachievementratiowas94.6%withtheaveragediameterofPDA(6.2±3.2)mm.InGroupBthetechnicalachievementratiowas100%withtheaveragediameterofPDA(4.8±2.5)mm.WeusedtheAmplatzerDuctOccluderwiththetypefrom6-8mmto12-14mm,thedeliverysheathfrom6Frenchto8French.24hoursafterintervention,echocardiographydemonstratedthattherewere6residualshuntsinGroupAwhile22inGroupB.After1year,residualshuntexistedinneithergroup.Therewere4patientswhosefemoralarteriespulsedweaklyafterinterventioninGroupA,whileinGroupBtherewere3.Theyallrecovered24hoursaftertheapplicationofurokinase.InGroupAbloodflowvelocityindescendingaortaincreasedin5infants,whileinGroupBtherewere3.Theyallresumedin6-12months.ConclusionsTranscatheterclosureofPDAininfantsissafeandtechnicallyfeasible.However,indicationshouldbestrictlyselectedandtheinterventionshouldbeperformedbyexperiencedphysician.

简介：ObjectiveToassesstheutilityoflow-andhigh-frequencytympanometryinthediagnosisofmiddleeardysfunctioninChineseinfants.MethodsTympanogramswereobtainedwith226Hz,678Hzand1000Hzprobetonesfrominfantsaged5-25weekswithnormalauditorybrainstemresponses(ABRs)(15infants,30ears)andwithprolongedwaveIlatencies(17infants,20ears),suggestingmiddleeardysfunction,usingaGSITympstarmiddleearanalyzerVersionII.ResultsThesingle-peakedtympanogramwasthemostcharacteristictypeinbothgroupsandseenin25ears(83.3%)inthenormalABRgroupandin18ears(90%)inthedelayedwaveIgroup,respectively.Thepeakpressure,peakcompensatedstaticacousticadmittanceandgradientof226Hztympanometrywereofnosignificantdifferencesbetweenthetwogroups.The678Hztympanogramsofadmittance,susceptanceandconductancedemonstratednon-peak,single-,double-andtri-peakedpatternsinbothgroups.TheagreementbetweenABRsand678Hztympanogramsofadmittance,susceptanceandconductancewere70.0%,58.0%and64.0%(kappa=0.324,0.234and0.118)respectively.For1000Hzprobetone,admittance,susceptanceandconductancetympanogramsshowedsinglepeakedpatternsin28(93.3%),25(83.3%)and26(86.7%)ofthe30normalears.Admittance,susceptanceandconductancetympanogramsusingthe1000Hzprobetonewereflatin15(75%),17(85%)and13(65%)oftheearsininfantswithprolongedwaveIlatencies.For1000Hzadmittance,susceptanceandconductanceTympanograms,theagreementbetweentympanometryandABRresultswere90.0%,92.0%and86.0%withkappaat0.783,0.831and0.690,respectively.Conclusion1000Hzprobetonetympanometryisapromisingmiddleearfunctiontestforinfantsof1-6monthsage,while226Hzand678Hzprobetonesarelessefficientindetectingmiddleeardysfunctionininfants.

简介：GrindinginkwasanimportantstepofpaintingandwritingforChineseliteratiinancienttimes.PainterMr.LiPingyehasbeengrindinghisinkfornearly80years.Itisdifficulttotellwhetherhehasbeengrindinginkortheinkhasbeengrindinghim.ThisfamouscontemporaryChinesetraditionalpainterhasexperiencedinnumerablefrustrationsandsufferingsoflife.

简介：摘要白介素17（IL-17）在调解中性粒细胞补充和粒细胞生成方面起着重要作用，同时IL-17还是重要的促炎因子可诱导其他细胞因子和组织降解酶的产生，提高一些细胞因子的功能。因此IL-17扮演着双重角色。本文就IL-17在肺炎中的作用的相关研究进展加以综述。

简介：AcupointShousanli(LI10)isalsocalledShangsanli,Guixie,locatesattheradialaspectofthebackoftheforearm,2cunbelowQuchi(LI11),onthelinejoiningYangxi(LI5)andQuchi(LI11).Shousanli(LI10)wasfirstlyrecordedinZhenJiuJiaYiJing(A-BCanonofAcupunctureand

简介：目的：探讨针刺疗法结合康复对围产期脑损伤高危儿智力及运动发育的影响。方法：对97例经新生儿重症监护室（NICU）救治存活的围产期脑损伤高危儿，按患儿家长意愿划分两组，针刺组53例，采用针刺结合康复治疗。对照组44例，采用常规育儿方式。两组均系统跟踪随访至2周岁，于6、12、24月龄时由专人定期采用婴幼儿智能发育量表进行智能测定。结果：针刺组在2岁时智力发育指数（MDI）与运动发育指数（PDI）分别高于对照组14．69、9．82分；针刺组智能异常率为15．1％，明显低于对照组40．9％，两组间差异具有统计学意义（χ2=8．1659，P〈0．01）。结论：针刺结合康复能有效地促进围产期脑损伤高危儿智力及运动发育，是改善预后、减少伤残率．提高患儿生存质号自勺有效丰段．

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