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简介:Theauthorsstudyaporousmediumequationwitharight-handside.TheoperatorhasnonlocaldiffusioneffectsgivenbyaninversefractionalLaplacianoperator.ThederivativeintimeisalsofractionalandisofCaputo-type,whichtakesintoaccount'memory'.TheprecisemodelisD_t~αu-div(u(-Δ)~(-σ)u)=f,0<σ<1/2.Thispaperposestheproblemover{t∈R~+,x∈R~n}withnonnegativeinitialdatau(0,x)≥0aswellastheright-handsidef≥0.Theexistenceforweaksolutionswhenf,u(0,x)haveexponentialdecayatinfinityisproved.ThemainresultisH¨oldercontinuityforsuchweaksolutions.
简介:在在参考书在中等Mn钢上总结相关研究以后,张力的性质上的二个新目标被定义。一个人两个都是那导致转变(旅行)并且导致双胞胎的粘性(缇)能与一个相对低的Mn内容为钢被认识到,它与更高的Mn内容展出类似的张力的性质到古典缇钢。其它将完成超离频的最终的张力的力量(>1.5?GPa)没有牺牲formability。达到这些目标,新设计策略为作文和处理线路被提出。特别地,因为前者能经由部分再结晶与不同形态学和尺寸生产保留的奥氏体谷物的混合物,温暖的滚动被采用而不是平常的热/冷的滚动过程。因而,保留的奥氏体谷物有大量技工稳定性以便他们能在变丑期间逐渐地转变到马氏体,导致提高的旅行效果然后改进技工性质。最后,它在在实验室生产这些指向的中等Mn钢被接替,他们中的一些甚至比我们的期望展出更好张力的性质。
简介:Therelationbetweengrain-sizedistributionofthebedandinsuspensionwascriticallyexaminedunderauniformflowvelocityof50cm/sovertwobeds:oneofmainlyfinesandsandtheotherofmediumsands.Twosections-one2.85mdownstreamandtheother6.35mdownstreamintheexperimentalchannel-wereselectedforsamplingtostudythegrain-sortingpatternintheverticaldirectionalongthedirectionoftransport.Theshapeandtypeofthegrain-sizedistributionpatternwerecriticallystudiedwithheightabovethebed.Thechangeinthedistributionpatternhasbeenattributedtothechangeoflocalbedroughnesscausingscouringagainsttheprotrudedrelativelycoarsegrainsonthebed.Suchtrendsareimportanttopredictthenatureofriverbedtopography.ThesandofBed-1initiallyexhibitsalog-skew-Laplacedistributionatdifferentheightsofsuspension.Thedistributionpattern,however,changesbutthischangingpatternisnotconsistentalongtheupstreamside.ForBed-2,whichinitiallyexhibitsalog-normaldistribution,thesamepatternpersistsfromtheheightofsuspensionat5cmupto20cm.Suchconsistencyinlog-normalityisalsoobservedatthedownstreampointsofmeasurement.Itisgenerallyexpectedthatthemeangrain-sizewouldreducewithincreasesofsuspensionheightbuttheresultsoftheexperiments,insomeoccasions,differsignificantlyfromthegradualfiningupwardtrend.Thisresulthasbeenattributedtolocalchangesofbedroughnessarisingfromtheprotrudedrelativelycoarsegrainscausingeddies,scouring,andturbulentphenomenawhichmovescoarseparticleshigherinsuspensionaddingacoarsetailtothedistributionincreasingthemeangrain-size.
简介:NocathiacinI,aglycosylatedthiopeptideantibiotic,displaysexcellentantibacterialactivitiesagainstmultidrugresistantbacterialpathogens.Previously,anovelnocathiacinIformulationforintravenousadministrationhasbeensuccessfullydevelopedanditsaqueoussolubilityisgreatlyenhancedforclinicalapplication.ThepurposeofthepresentstudywastoincreasethefermentationtiterofnocathiacinIandreduceoreliminateanalogousimpuritiesbyscreeningthemediumingredientsusingresponsesurfacemethodology.Afterasysmaticoptimization,awater-solublemediumcontainingquality-controllablecomponentswasdevelopedandvalidated,resultinginanincreaseintheproductionofnocathiacinIfrom150to405.8mg·L-1at150-Lscale.Meanwhile,theanalogousimpuritiesexistedinreportedprocessesweregreatlyreducedoreliminated.Usingoptimizedmediumforfermentation,nocathiacinIwithpharmaceuticallyacceptablequalitywaseasilyobtainedwitharecoveryof67%.Inconclusion,theresultsfromthepresentstudyofferapracticalandefficientfermentationprocessfortheproductionofnocathiacinIasatherapeuticagent.
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简介:AprotocolformicropropagationusingnodalexplantsfrommaturePinusmassonianatreeshasbeendeveloped.Timeofexplantcollectioniscrucialfortheinitialsuccessofasepticculture.ExplantscollectedinearlyMarchgavethehighestpercentageofexplantsurvival(64.5%)andshoot-formingpercentage(52.3%).Thidiazuron(TDZ)concentrationsignificantlyinfluencedshootformation;4lMTDZwasoptimum,with4.8shootsproducedperexplantwithameanlengthof7.1cmafter120daysofculture.Regeneratedshootsrootedfor60daysinbasicmediumwith1lMNAAwerereadyforgrowthinpots.ThisisthefirstreportonplantletregenerationinvitrofrommaturetreesofP.massonianathatprovidesareliablemethodforpropagatingselectedelites.