简介：Functionaltricuspidregurgitation(TR)primarilyarisesfromasymmetricdilationofthetricuspidannulusinthesettingofrightventriculardysfunctionandenlargementinresponsetoleft-sidedmyocardialandvalvularabnormalities.EveniftheTRisnotsevereatthetimeofmitralvalvesurgery,itcanworsenandevenappearlateaftersuccessfulmitralvalvesurgery,whichportendsapoorprognosis.DespitedatademonstratinginferioroutcomesinthepresenceofresidualTR,surgicalrepairforfunctionalTRremainsunderused.AcceptanceofTR,inthepresenceoftricuspidannulardilation,maybeunacceptable.Surgicalrepairshouldconsistofplacementofarigidorsemirigidannularring,whichhasbeenshowntoprovidesuperiordurabilityascomparedwithsutureandflexiblebandtechniques.Finally,percutaneousannuloplastyforcorrectionoffunctionalTRmayallowtreatmentofpatientswithrecurrentTRathighriskofreoperation.

简介：Asearlyas2000yearsago,ancientChinesemedicalrecordshaddescribedtherelationshipbetweendiseasesandappearanceindetail.Moreover,modernmedicinehasalsoconstantlystudiedtherelationshipbetweenfacialfeaturesandhealthinevolutionaryterms.Itiswellknownthatmanyhereditarydiseasesinvolvecertainabnormalfacialfeaturesandgenemutations.Thetumorisalsoconsideredasgeneticdisordertosomeextent,sowhatistherelationshipbetweencancergeneticsandcongenitaldevelopmentoffacialfeatures?Here,wereviewedsomecluestotheappearance-gene-tumorrelation,whichmightbecomethetargetsintheearlypreventionorgenetherapyofcancerinthefuture.Thissummaryprovidedusanewstrategyforthecancergeneticscreeningandanewresearchdirectionforgeneticdiagnosisofthepotentialdisease.

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简介：在q差别操作员下面的全部功能的生长在这份报纸被学习，然后朱莉娅的一些性质在q差别操作员被获得的更高的目下面全部功能设定。

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简介：LetL=-△+VbeaSchrodingeroperatoronRn(n≥3),wherethenon-negativepotentialVbelongstoreverseHolderclassRHq1forq1>n/2.LetHLp(Rn)betheHardyspaceassociatedwithL.Inthispaper,weconsiderthecommutator[b,Tα],whichassociatedwiththeRiesztransformTα=Vα(-?+V)-αwith0<α≤1,andalocallyintegrablefunctionbbelongstothenewCampanatospaceΛβθ(ρ).Weestablishtheboundednessof[b,Tα]fromLp(Rn)toLq(Rn)for1

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简介：磨擦促使处理(FSP)作为在12修理裂缝的一个方法被调查?公里厚304L不锈钢板。愈合的可行性被用一个PCBN/W-Re工具处理一个逐渐变细的裂缝与表明一25?公里直径肩膀和6.4的大头针长度?公里。实验证明愈合是可能的开始的一个裂缝狭窄然后日益增多地长大到2的宽度?公里。板实验上的祷告被用来为创造发现最好的参数一巩固与贱金属相比与坚硬差别的最少的数量搅动地区。在一些标本的谷物精炼更高导致了大部分搅动地区坚硬，与贱金属相比。谷物尺寸对microhardness的一个阴谋显示出在谷物尺寸和坚硬之间的很强壮的反的关联，从Hall-Petch关系期望。腐蚀测试被执行以便在stir地区的潜在的促进感受性上评估FSP的效果。在1000以后?在在没有腐蚀产品在基础材料控制上或在任何磨擦上形成了，这被发现的房间温度的3.5%盐溶液的断断续续的沉浸的h搅动处理标本。

简介：Objective:Toinvestigatetherelationshipbetweengenemutationandpathologicaltypeoflungcancer,inspectandverifytheconsistencybetweenhomologousgenesmutationinvariouspathologictype.Methods:CombinedwiththeCOSMICandUniProtdatabase,weobtainedthereportedoverallbig-samplemutationdataoflungcancerandtheproteinsequencesofthetop20mutatedgenes,respectively.Analyzethedataandclustertheproteinsequencesandthendeducethehomologousgene.Ultimately,analyzethemutationsofdifferentpathologicaltypesofhomologousgenes.Results:TP53(32.32%)hasthehighestmutationrateinlungcancer,followedbyEGFR(29.12%).Thecopynumbervariability(CNV)ofgenes:KRAS,LRP1B,CDKN2A,KMT2C,FAT1,PIK3CA,RB1,ERBB4,GRIN2AandKDRbetweeneachpathologicaltypeisstaticallysignificant(P<0.05).ThegenedifferentialexpressionratebetweenadenocarcinomaandsquamouscarcinomaofgeneTP53,KRAS,LRP1B,CDKN2A,STK11,FAT4,KMT2D,NFE2L2,KEAP1,PIK3CA,RB1,ERBB4,SMARCA4andKDRarestatisticallysignificant(P<0.05).ThesimilarityoftheproteinsequenceofEGFRandERBB4canreach93%,andFAT4andFAT1are81%.Forsmallcellcarcinoma,there’snodifferenceinCNVbetweenthetwogroupsofhomologousgenes,andnodifferencebetweenFAT4andFAT1inadenocarcinoma.Conclusion:TheCNVandgeneexpressionoflungcancer-associatedgenesarerelevanttopathologictypes.GFRandERBB4arehomologous,FAT4andFAT1arealsoamongthetop20mutationgenes.Additionally,there’snodifferenceinCNVbetweenthetwogroupsofsmallcellcarcinoma,whichisthesamebetweenFAT4andFAT1inadenocarcinoma.

简介：Objective:Tounderstandthecrucialroleoftheklothogeneinhearingdevelopmentinmousemodels.Methods:PCRwasusedtoidentifyCBAmicewithdifferentgenotypes,i.e.WT,heterozygous(klotho+/-)orhomozygous(klotho-/-).Micephenotypeandweightwererecordedpostnatal25days(P-25)andauditorybrainstemresponses(ABR)wereusedtodetermineauditoryfunctionatP-60.Results:klotho-/-micetendedtohavesmallersize,lighterweightandhigherABRthresholdsatP-60,showingearlyonsetage-relatedhearingloss(ARHL).Conclusion:Heterozygousandhomozygousklothodeficientmiceexhibitdifferentdegreesofhearinglossatyoungage,withhomozygousmice(klotho-/-)showingmoreseverehearingloss.OurresultsindicatethatpersistedexpressionofklothoproteinintheinnerearmaypotentiallydelaytheonsetofARHLandplayanimportantroleintheprotectionofauditoryfunction.

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简介：Inthisarticle,the2-variablegeneralpolynomialsaretakenasbasewithPeterspolynomialstointroduceafamilyof2-variablePetersmixedtypepolynomials.Thesepolynomialsareframedwithinthecontextofmonomialityprincipleandtheirpropertiesareestablished.Certainsummationformulaeforthesepolynomialsarealsoderived.Examplesofsomemembersbelongingtothisfamilyareconsideredandnumbersrelatedtosomemixedspecialpolynomialsarealsoexplored.

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简介：通过每从终端双边地出现的神经IV-VI投射腹的中心(标签)的不同neuronalsubpopulations的morphofunctional调查在控制与在女吉普赛人蛾Lymantriadispar叫行为联系的产卵管运动的中心与octopaminergic活动被相关。从神经树桩的Tetramethylrodaminedextran装填导致了标签设计的一个相对低的数字，为神经对IV从12～13，12～14为神经配对V，并且8～9为神经对VI。而且由electrophysiological记录估计了在每这些神经显示以内的很多纤维自发的补品活动，也，中心是什么时候，充分从腹的神经绳索(VNC)断开了。到TAG的Octopamine(OA)应用强烈提高了这些神经的活动，由增加很多个自发地开火的单位或由招募的开火的率的任何一个新的。这项octopaminergic活动影响了打电话的行为，并且明确地导致在片断VIII和IX(产卵管)之间的intersegmental膜(IM)的骑车的延期的肌肉活动。我们的结果在女吉普赛人蛾显示那TAG的神经活动是的octopaminergic为释放pheromone的目的结合了IM的延期和收回，在神经对IV刺激的马达单位关于神经刺激的那些显得对抗的地方，配对V。

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简介：Sincethecarbohydratecontentaffectspearflavorduringtheprocessofgrowth,itisnecessarytodeterminethesugarcomponentsthataccumulateinthefruit.Weanalyzedthefruitcarbohydratecontent,andthegeneexpressionandactivityofacidinvertase(AI),neutralinvertase(NI),sucrosesynthase(SS),andsucrosephosphatesynthase(SPS)duringthedevelopmentof“Huangguan”and“Yali”pears.Theresultsdemonstratethatduringdevelopment,thefruitsugarmetabolismofthe“Huangguan”pearfollowsatypicalsorbitol–starch-solublesugarsmiddlemodel,whereasthe“Yali”pearfruitfollowsatypicalsorbitol–sucrose–starch-solublesugarsmiddlemodel.Inthe“Huangguan”pear,wefoundtheAIandNIgeneexpressions,aswellasAI(P<0.05)andNI(P<0.01)enzymeactivities,tobepositivelycorrelated,whereaswefoundtheNIgeneexpressionandNIenzymeactivityof“Yali”peartobenegativelycorrelated(P<0.01).Weobservedthehighlevelsoflate-stageAIandearly-stageSSduringdevelopmenttoroughlycorrespondwiththegeneexpressionfoundinthelateandearlystages,respectively,suggestingtheirpotentialregulatoryrolesin“Huangguan”pearfruitdevelopment.OurresultsindicatethattheprimaryfunctionofSPSduringtheearlydevelopmentalstageistoaccumulatesucrose,whereastheprimaryfunctionofAIistopromotehexoseaccumulationduringthelatedevelopmentalstageofmature“Yali”pearfruit.