简介:与女乳癌相比,男乳癌是稀罕疾病,并且在临床/病理学的特征和预后之间的关系争论,或甚至大部分未知。在这研究,我们从合用的男乳癌病人在天津医药大学癌症研究所和医院从1996年1月对待到2011年12月的109nonmetastatic用临床、病理学的数据执行了回顾的分析。木头等级测试证明那降低肿瘤舞台,没有淋巴节点参与,和积极雌激素/孕酮受体地位是没有疾病的幸存和外套的好预言者univariate分析上的幸存。然而,hormonotherapy仅仅是没有疾病的幸存,并且不全面幸存的一个好预兆的因素。另外,基于考克斯,比例的危险回归模型,仅仅淋巴节点参与,和雌激素/孕酮受体地位是multivariate分析上的统计上重要的预兆的因素。我们的结果证明尽管辅助全身的治疗在男乳癌广泛地被使用,病人和预后在最后几十年,淋巴节点参与,和雌激素/孕酮受体地位改善了仍然是最重要的预示的因素。有一种更大的样品尺寸的未来的多中心研究着急地被需要进一步理解男乳癌。
简介:Perivascularepithelioidcelltumor(PEComa)ofthepancreasisanunusualtumorderivingfrommesenchyma.ThispaperdescribedacaseofpancreaticPEComa,whichwasinitiallysuspectedasneuroendocrinecarcinomabybiopsy,andthereforesurgicaltreatmentwasrecommendedduetoundetermineddiagnosis.Examinationofthesurgicalspecimenunderamicroscopeshowedthatthetumorcell’smorphologywasepithelioidorspindle-shaped,andrangedinanestedpattern.Additionally,thesecellshadalargeextentofacidophiliccytoplasm,nomitoticfigures,andexpressedHMB-45,melan-p,andsmoothmuscleactinimmunohistochemically.PathologicalexaminationindicatedthatPEComaoriginatedfromthepancreas,butsymptomsrelatedtotuberoussclerosiswereabsent.SincePEComaisextremelyrareinthepancreas,itislikelytobeignoredindifferentialdiagnosis.Inconclusion,ourarticlehighlightedtheclinicopathologicalfeaturesofPEComa,andweconductedaliteraturereviewfocusingonPEComasoastodeepentheunderstandingofthistumortype.
简介:AIM:Toevaluategutmicrobialdysbiosisintwovisceralhypersensitivemodelsincomparisonwithirritablebowelsyndrome(IBS)patientsandtoexploretheextenttowhichthesemodelscapturethedysbiosisofIBSpatients.METHODS:Visceralhypersensitivitywasdevelopedusingthematernalseparation(MS)ratmodelandpost-inflammatoryratmodel.Thevisceralsensitivityofthemodelgroupsandcontrolgroupwasevaluatedusingtheabdominalwithdrawreflexscoreandelectromyographyinresponsetogradedcolorectaldistention.The16SribosomalRNAgenefromfecalsampleswaspyrosequencedandanalyzed.Thecorrelationbetweendysbiosisinthemicrobiotaandvisceralhypersensitivitywascalculated.PositivefindingswerecomparedtosequencingdatafromapublishedhumanIBScohort.RESULTS:Dysbiosistriggeredbyneonatalmaternalseparationwaslastingbutnotstatic.BothMSandpostinflammatoryratfecalmicrobiotadeviatedfromthatofthecontrolratstoanextentthatwaslargerthantheco-housingeffect.Twoshortchainfattyacidproducinggenera,FusobacteriumandClostridiumXI,weresharedbythehumanIBScohortandbythematernalseparationratsandpost-inflammatoryrats,respectively,todifferentextents.FusobacteriumwassignificantlyincreasedintheMSgroup,anditsabundancepositivelycorrelatedwiththedegreeofvisceralhypersensitivity.Porphyromonadaceaewasaprotectivebiomarkerforboththeratcontrolgroupandhealthyhumancontrols.CONCLUSION:ThedysbiosisMSratmodelandthepost-inflammatoryratmodelcapturedsomeofthedysbiosisfeaturesofIBSpatients.Fusobacterium,ClostridiumXIandPorphyromonadaceaewereidentifiedastargetsforfuturemechanisticresearch.
简介:TheDeepSeismicSounding(DSS)projectscarriedoutfromthe1970sinthelowerYangtzeregionanditsneighboringareawerereviewedinthispaper,thenthebasicwavegroupfeaturesofthosewideanglereflection/refractionrecordsections,andofthecrustalstructurearesummarized.Itshowsthattherewereintotalfiveclearwavegroupsontherecordsections,whichincludethefirstarrivalPg,thereflectionP1fromthebottominterfaceoftheuppercrust,thereflectionP3fromthebottominterfaceofthemiddlecrust,thestrongreflectionPmfromtheMohoboundary,andtherefractionPnfromuppermostmantle.Ingeneral,thesephasesareeasilyconsistentlytracedandcompared,despitesomefirstarrivalsbeingdelayedorarrivingearlierthannormalduetotheshallowsedimentarycoverorbedrocks.Inparticular,intheDabieMountainregiontheseismiceventsofafewgatheredshotsalwayshaveweakreflectionenergy,aretwisted,orexhibitdisorganizedwaveforms,whichcouldbeattributedtothedisruptionvariationsofreflectiondepth,thebrokenMoho,andthediscontinuityofthereflectionboundarywithincrust.Theregionalcrustalstructuresarecomposedoftheupper,middleandlowercrust,ofwhichthemiddleandlowerlayerscanbedividedintotwoweakreflectionones.ThecrustalthicknessoftheNorthChinaandYangtzeplatformare30km-36km,andtheMohoexhibitsaflatgeometrydespitesomelocaluplifts.Theaveragepressurevelocityinlowercrustbeneaththistwotectonicareais6.7±0.3km/s.Nevertheless,beneaththeDabieshanareathecrustalthicknessis32km-41km,theMohobendsdownsharplyandtakesanabrupt4km-7kmdislocationintheverticaldirection.TheaveragepressurevelocityinthelowercrustbeneaththeDabieshanareais6.8±0.2km/s.