简介：Inthisarticle,theauthorlistedalotoffactstoillustratethehealthhazardsmaybemetduringtravel,anddescribedvarioushealthproblemcausedbythehazards.Travelersmayknowthesehazardsandthentakethenecessarypreventionmeasuresthroughtravelhealthconsultation.Andthetravelersthemselvesmayassistthedoctorsindiagnosisandcurethehealthproblemrelatedtotravel.Inthiswaythetravelershealthmaybeprotected.TheauthorpointedoutthattheChinesepeopleshouldcreatetheirownenvironmentandtrainstaffforthegraduallyinitialingoftravelhealthconsultation.

简介：One-cellmouseembryosfromKMstrainandB6C3F1strainwereculturedinM16medium,inwhich2-cellblockgenerallyoccurs.EmbryosofKMstrainexhibited2-cellblock,whereasB6C3F1embryos,whichareregardedasanonblockingstrain,proceededtothe4-cellstageinourculturecondition.Itisoftenassumedthattheblockofearlydevelopmentisduetothefailureofzygoticgeneactivation(ZGA)inculturedembryos.Inthisstudyweexaminedproteinsynthesispatternsbytwo-dimensionalgelelectrophoresisof[35S]methionineradiolabeled2-cellembryos.Embryosfromtheblockingstrainandthenonblockingstrainwerecomparedintheirdevelopmentbothinvitroandinvivo.ThedetectionofTRCexpression,amarkerofZGA,at42hposthCGinKMembryosdevelopedinvitrosuggestedthatZGAwasalsoinitiatedeveninthe2-cellarrestedembryos.Nevertheless,asignificantdelayofZGAwasobservedinKMstrainascomparedwithnormallydevelopedB6C3F1embryos.AttheverybeginningofmajorZGAasearlyas36hposthCG,TRChasalreadybeenexpressedinB6C3F1embryosdevelopedinvitroandKMembryosdevelopedinvivo.Butfor2-cellblockedKMembryos,TRCwasstillnotdetectableevenat38hposthCG.Theseevidencessuggestthat2-cell-blockedembryosdoinitiateZGA,andthat2-cellblockphenomenonisduenottothedisabilityininitiatingZGA,buttoadelayofZGA.

简介：AbstractWe analyzed variations in the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) genome during a flight-related cluster outbreak of coronavirus disease 2019 (COVID-19) in Shenzhen, China, to explore the characteristics of SARS-CoV-2 transmission and intra-host single nucleotide variations (iSNVs) in a confined space. Thirty-three patients with COVID-19 were sampled, and 14 were resampled 3-31 days later. All 47 nasopharyngeal swabs were deep-sequenced. iSNVs and similarities in the consensus genome sequence were analyzed. Three SARS-CoV-2 variants of concern, Delta (n = 31), Beta (n = 1), and C.1.2 (n = 1), were detected among the 33 patients. The viral genome sequences from 30 Delta-positive patients had similar SNVs; 14 of these patients provided two successive samples. Overall, the 47 sequenced genomes contained 164 iSNVs. Of the 14 paired (successive) samples, the second samples (T2) contained more iSNVs (median: 3; 95% confidence interval [95% CI]: 2.77-10.22) than did the first samples (T1; median: 2; 95% CI: 1.63-3.74; Wilcoxon test, P = 0.021). 38 iSNVs were detected in T1 samples, and only seven were also detectable in T2 samples. Notably, T2 samples from two of the 14 paired samples had additional mutations than the T1 samples. The iSNVs of the SARS-CoV-2 genome exhibited rapid dynamic changes during a flight-related cluster outbreak event. Intra-host diversity increased gradually with time, and new site mutations occurred in vivo without a population transmission bottleneck. Therefore, we could not determine the generational relationship from the mutation site changes alone.

简介：Thegrowingcorrelationlengthpriortothemoderate-greatearthquakesoccurredinGansuProvinceanditsnearbyareasince1986hasbeenstudiedusingthemethodofsingle-linkclusteranalysis(SLC).Accordingtodifferentconditionsinthesourcearea,thecircularspatialwindowcenteredintheepicenterandtheparallelgrammicspatialwindowalongthefaultbelthavebeenselected.Theresultsshowthatthephenomenaofgrowingcorrelationlengthhavebeenobservedbeforetheearthquakesstudiedinthepaper.

简介：Thedensebroadbandseismicnetworkprovidesmorehigh-qualitywaveformthatishelpfultoimproveconstraintfocaldepthofshallowearthquake.Manyshallowearthquakesoccurringinsedimentwereregardedasinducedevents.InSichuanbasin,gasindustryandsaltminingaredependentonfluidinjectiontechniquethattriggersmicroseismicity.WeadoptedwaveforminversionmethodwithregionalrecordstoobtainfocalmechanismofanMs4.8earthquakeatChangning.TheresultsuggestedthattheChangningearthquakeoccurredataESEthrustfault,anditsfocaldepthwasabout3km.ThedepthphasesincludingteleseismicpPphaseandregionalsPLphaseshowsthatthefocaldepthisabout2km.Thestrong,shortperiodsurfacewavesuggeststhatthiseventisaveryshallowearthquake.TheamplituderatiobetweenRayleighwaveanddirectSwavewasalsousedtoestimatethesourcedepthofthemainshock.Thefocaldepth(2–4km)isfarlessthanthedepthofthesedimentarylayerthickness(6–8km)inepicentralregion.Itisclosetothedepthoffluidinjectionofsaltmining,whichmayimplythatthiseventwastriggeredbytheindustrialactivity.

简介：FLATModel是包含几原版的有限的卷代码接近改进碎片流动模拟的2D。第一，FLATModel在每个房间合并一种定期而不断被迫停的技术允许碎片流动团的连续倒塌和动员。第二，流动速度并且因而，收益应力直接与流变学的类型被联系改善边界精确性。第三，为乘火车的一条简单途径也在模型被包括分析碎片流动的基础侵蚀的效果。FLATMODEL在发生在东方比利牛斯山脉的几个事件被测试，模拟结果显示模型能代表在这块地里观察的不同特征相当好。

简介：ThemainshockandaftershocksoftheHutubiMS6.2earthquakeonDecember8,2016wererelocatedbyapplyingthedoubledifferencemethod,andwerelocated477earthquakesintheHutubiregion.Theearthquakerelocationresultsshowthattheaftershocksaredistributedintheeast-westdirectiontowardsthenorthsideofthesouthernmarginoftheJunggarBasinfault,andaremainlydistributedinthewesternregionofthemainshock.ThedistancebetweenthemainshockafterrelocationandthesouthernmarginoftheJunggarBasinfaultisobviouslyshortened.Combinedwiththefocalmechanismandthespatialdistributionofthemainshockandaftershocks,itisinferredthatthesouthernmarginoftheJunggarBasinfaultisthemainseismogenicstructureoftheHutubiearthquake.

简介：Assessmentofanacutelypoisondepatientfollowstheestablisedclinicalmethod(Figure1):

简介：AbstractTraditional radiotherapy and chemotherapy often cause irreversible damage to the fertility and endocrine function of cancer patients. The current methods of fertility preservation include freezing the sperms of adult and adolescent males after puberty; freezing the embryos, oocytes, and ovarian tissue of females; and drug intervention and fertility preservation surgery. This article reviews fertility preservation in cancer patients with respect to current methods, indications, and some more recently developed methods that remain under investigation.

简介：AbstractFractures of the acetabulum in elderly patients were often caused by low energy trauma. Fractures involving anterior column are more common and often associated with impaction and comminution. Osteoporosis further complicates the management. Percutaneous fracture fixation has low morbidity but it is a technically demanding procedure. Open reduction and fracture fixation is done with or without simultaneous total hip replacement. Delayed total hip replacement is considered in posttraumatic arthritis patients. Patients with minimal displaced fractures, associated both-column fractures with secondary congruence of joint and patients who are medically unfit for surgery can be managed non-operatively. Whatever be the method of management, these elderly patients should be mobilised as early as possible.

简介：与多重损伤在病人为错误诊断探索特征，治疗结果和原因的目的，以便减少错误诊断的发生。从1997年8月被同意进入我们的部门到2008年8月的有多重损伤的3163个病人全部的方法A，回顾地被学习比较诊断和治疗的特征。有2117男性(66.93%)，有平均数的1046女性(33.07%)36.46年变老(范围，14-80年)。象一般地位，创伤的条件，诊断和治疗状况，预后和死亡那样的参数被分析。错误诊断组和正确诊断组之间的差别以阐明的损害，复杂并发症和治疗结果的严厉被比较错误诊断的原因和预防。结果在这研究的多重损伤的错误诊断率是16.19%。误诊的主要解剖地点是手足和骨盆(299个位置，39.50%)，腹的区域和骨盆的机关(148个位置，19.55%)，并且胸的区域(109个位置，14.40%)。在错误诊断组，ISS，一些医院停留，知觉的骚乱的率，批评盒子和吃惊，盒子是33.78吗？

简介：

简介：

简介：Epithelialovariancancerisprimarilyadiseaseofolderwomen.Advancedageisriskfactorfordecreasedsurvival.Optimalsurgeryandthesafeandeffectiveadministrationofchemotherapyareessentialforprolongedprogression-freeandoverallsurvival(OS).Inthisarticle,theavailableregimensinboththeprimarytreatmentandrelapsedsettingarereviewed.

简介：BackgroundThisarticlesummarizedtheexperienceofatrioventricularvalvereplacementoperationforfunctionalsingleventriclepatientswhoseatrioventricularvalvewasinsufficiency.Thefollow-uptimeofoperationwasarrangedfromearly-tomedium-term.MethodsFromJuly2009toJuly2015,therewere40patientsoffunctionalsingleventriclereceivingtheoperationofatrioventricularvalvereplacement,including23maleand17femalepatients.TheageatA-Vvalvereplacementwasrangedfrom6daysto32years(themediumageof9years),andthebodyweightrangedfrom2.7to57kg(themediumbodyweightof21.5kg).Moreover,theatrioventricularvalvereplacementwasperformedonallpatientsunderextracorporealcirculation.ResultsAtrioventricularvalvereplacementwasperformedon40patientswithfunctionsingleventricleinhospital,ofwhicheight(20.0%)diedinhospitalincludingtwoneonateandinfant(agerange:6days-2yearsold)accountingfor25%(2/8),Amongthem,sevenpatientsdiedoflowcardiacoutputsyndrometwopatientswithrepeatedhypoxemiaconcurrentinfectionafteroperation,andonewithbilateraldiaphragmaticparalysisandmalignantarrhythmia.Forthepatientssufferingthesevereperivalvularleakage,therewasareoperation,andthecardiacfunctionbeforethefirstoperationwasclassⅣ.OnepatientreceivedhearttransplantationfinallyforsevereheartfailureafterAVvalvereplacement.Fortherestofpatients,theircardiacfunctionrecoveredtoclassⅠ-Ⅱafteroperation.ConclusionsForfunctionsingleventriclepatientswithatrioventricularvalveregurgitation,themortalityrateofatrioventricularvalvereplacementcanbeacceptediftheoperationwasindicated.Forpatientswithsevereatrioventricularvalueregurgitation,theresultoftheoperationintheearlyandmediumtermwassatisfying.Thus,theatrioventricularvalvereplacementservedasausefultreatmentforpatientsdiagnosedofA-Vvalveregurgitationandfunctionalsingleventricle.

简介：Treated50casesofrenalcolicwithelectroacupunctureandcomparedtheresultswiththoseintwocontrolgroups.Totaleffectiverateinthetreatmentgroup,controlgroupⅠandcontrolgroupⅡwas98.0%,90.0%and92.0%respectively.

简介：AbstractObjective:To measure the prevalence of depression in patients with psoriasis and to evaluate the relationship between the severity of psoriasis and depression and its effect on patients’ quality of life.Methods:A total of 154 patients with a confirmed diagnosis of psoriasis were assessed to determine the severity of psoriasis based on the psoriasis area and severity index score, presence, and severity of depression using the patient health questionnaire 9, and quality of life using the dermatology life quality index 10. Pearson correlation coefficient was used to demonstrate the relationship between continuous variables with 95% confidence intervals (CIs); P < 0.00001 was taken to indicate statistical significance.Results:The severity of psoriasis was mild in 36.36% of patients, moderate in 25.97%, severe in 32.47%, and very severe in 5.20%. Of the 154 patients, 139 (90.3%) had depression; the severity of depression was mild in most affected patients (46.7%) and severe in 2.6% of patients. Psoriasis had a moderate effect on the quality of life in 37.01% of patients and a very large effect in 33.77% of patients. The severity of psoriasis was positively correlated with depression (Pearson correlation coefficient, r= 0.42, P < 0.00001, 95% CI: 0.28-0.54) and quality of life (r= 0.43, P < 0.00001, 95% CI: 0.29-0.55).Conclusion:Depression is a common comorbidity in patients with psoriasis. The severity of psoriasis is positively correlated with the severity of depression and is associated with poor quality of life.

简介：AbstractBackground:Anorexia nervosa (AN) is a psychological disorder, which is characterized by the misunderstanding of body image, food restriction, and low body weight. An increasing number of studies have reported that the pathophysiological mechanism of AN might be associated with the dysbiosis of gut microbiota. The purpose of our study was to explore the features of gut microbiota in patients with AN, hoping to provide valuable information on its pathogenesis and treatment.Methods:In this cross-sectional study, from August 2020 to June 2021, patients with AN who were admitted into Peking University Third Hospital and Peking University Sixth Hospital (n = 30) were recruited as the AN group, and healthy controls (HC) were recruited from a middle school and a university in Beijing (n = 30). Demographic data, Hamilton Depression Scale (HAMD) scores of the two groups, and length of stay of the AN group were recorded. Microbial diversity analysis of gut microbiota in stool samples from the two groups was analyzed by 16S ribosomal RNA (rRNA) gene sequencing.Results:The weight (AN vs. HC, [39.31 ± 7.90] kg vs. [56.47 ± 8.88] kg, P < 0.001) and body mass index (BMI, AN vs. HC, [14.92 ± 2.54] kg/m2vs. [20.89 ± 2.14] kg/m2, P < 0.001) of patients with AN were statistically significantly lower than those of HC, and HAMD scores in AN group were statistically significantly higher than those of HC. For alpha diversity, there were no statistically significant differences between the two groups; for beta diversity, the two groups differed obviously regarding community composition. Compared to HC, the proportion of Lachnospiraceae in patients with AN was statistically significantly higher (AN vs. HC, 40.50% vs. 31.21%, Z = –1.981, P = 0.048), while that of Ruminococcaceae was lower (AN vs. HC, 12.17% vs. 19.15%, Z = –2.728, P = 0.007); the proportion of Faecalibacterium (AN vs. HC, 3.97% vs. 9.40%, Z = –3.638, P < 0.001) and Subdoligranulum (AN vs. HC, 4.60% vs. 7.02%, Z = –2.369, P = 0.018) were statistically significantly lower, while that of Eubacterium_hallii_group was significantly higher (AN vs. HC, 7.63% vs. 3.43%, Z = –2.115, P = 0.035). Linear discriminant effect (LEfSe) analysis (LDA score >3.5) showed that o_Lachnospirales, f_Lachnospiraceae, and g_Eubacterium_hallii_group (o, f and g represents order, family and genus respectively) were enriched in patients with AN. Microbial function of nutrient transport and metabolism in AN group were more abundant (P > 0.05). In AN group, weight and BMI were significantly negatively correlated with the abundance of Bacteroidota and Bacteroides, while positively correlated with Subdoligranulum. BMI was significantly positively correlated with Firmicutes; HAMD scores were significantly negatively correlated with Faecalibacterium.Conclusions:The composition of gut microbiota in patients with AN was different from that of healthy people. Clinical indicators have correlations with the abundance of gut microbiota in patients with AN.

简介：Objective:Toinvestigatethedepressionstatusofpatientswithsexuallytransmitteddiseases(STDs).Methods:Thedepressionstatusoffifty-onehospitalizedSTDpatientswasevaluatedinarandomizedcontrolstudyusingZung'sQuantitativeTable.18healthycontrolpatientswithsimilardemographicbackgroundswererandomlychosenascontrols.Patientswithscoresaboveorequalto40wereconsideredtobesufferingfromdepression.Results:Theprevalencerateofdepressioninthepatientgroupwasobviouslyhigherthanthatofinthecontrol(X2=16.456,P<0.01).Prevalenceofdepressionwasfoundtobesignificantlyrelatedtooccupation(P<0.05).Thoughtheprevalencewasnotfoundtodiffersignificantlybetweenthosewithatreatmentcourselessthan2monthsandthosewithonelongerorequalto2months(X2=0.041,P>0.05),themeandepressionscoresoftheformergroupweresignificantlyhigherthanthoseofthelatter(P<0.01).Nosignificantdifferenceswerefoundbetweennewversusrelapsingdisease,marriedversusnon-married,maleversusfemale,ordifferingeducationalbackgrounds.

简介：太极运动的架势比较平稳舒展，动作要求不僵不拘，符合人体的生理习惯，并且没有忽起忽落的明显变化和激烈的跳跃运动。所以，不同年龄、性别和体质的人，都可以参加锻炼；尤其是对体弱和患有一些慢性病的人，更是一种较好的体疗手段。