简介：AIM:Toevaluatewhetherthelevelofthrombospondin-1(TSP-1)inaqueoushumorcanpredicttheprognosisoftrabeculectomyinpatientswithprimaryangle-closureglaucoma(PACG).METHODS:Thiscase-controlstudyinvolved26patientswithPACGwhoexperiencedafailedtrabeculectomy(casegroup)and78age-andsex-matchedpatientswithPACGwhounderwentsuccessfultrabeculectomy(controlgroup).AqueoushumorwascollectedatthetimeoftrabeculectomyandtestedforTSP-1andTGF-β2levelswithanenzyme-linkedimmunosorbentassaymethod.Logisticregressionmodelingwasusedtoassesstheriskfactorsforfailedtrabeculectomy.RESULTS:ThemeanTSP-1aqueousconcentrationsweresignificantlyhigherinthecasegroup(20.67±9.79ng/mL)thanthecontrolgroup(5.17±2.29ng/mL)(P<0.001).Thetransforminggrowthfactor-β2(TGF-β2)aqueousconcentrationsweresignificantlydifferentbetweenthecaseandcontrolgroup,at3633.25and1090.24pg/mL,respectively(P<0.001).LogisticregressionanalysisrevealedTSP-1levelasanindependentriskfactorforafailedtrabeculectomy(OR=3.540;95%CI=1.092-11.482).CONCLUSION:TheaqueoushumorTSP-1andTGF-β2levelsarehigherinPACGeyeswithfailedtrabeculectomythanwithsuccessfultrabeculectomyatoneyear.TheaqueoushumorTSP-1levelisanindependentriskfactorassociatedwithfailedtrabeculectomy.

简介：目的：观察针剌双侧穴位治疗中风后偏瘫的临床效果，浅析其作用机理。方法：取41例患者采用双侧取穴针剌为治疗组：设40例患者取惠侧穴位针刺为对照组。结果：经3个疗程治疗，中风后偏瘫改善．治疗组明显优于对照组结论：针刺双侧穴位可增强疗效。

简介：AbstractBackground:Reviving patients with prolonged disorders of consciousness (DOCs) has always been focused and challenging in medical research. Owing to the limited effectiveness of available medicine, recent research has increasingly turned towards neuromodulatory therapies, involving the stimulation of neural circuits. We summarised the progression of research regarding neuromodulatory therapies in the field of DOCs, compared the differences among different studies, in an attempt to explore optimal stimulation patterns and parameters, and analyzed the major limitations of the relevant studies to facilitate future research.Methods:We performed a search in the PubMed database, using the concepts of DOCs and neuromodulation. Inclusion criteria were: articles in English, published after 2002, and reporting clinical trials of neuromodulatory therapies in human patients with DOCs.Results:Overall, 187 published articles met the search criteria, and 60 articles met the inclusion criteria. There are differences among these studies regarding the clinical efficacies of neurostimulation techniques for patients with DOCs, and large-sample studies are still lacking.Conclusions:Neuromodulatory techniques were used as trial therapies for DOCs wherein their curative effects were controversial. The difficulties in detecting residual consciousness, the confounding effect between the natural course of the disease and therapeutic effect, and the heterogeneity across patients are the major limitations. Large-sample, well-designed studies, and innovations for both treatment and assessment are anticipated in future research.

简介：AbstractPurpose:Trauma has been called the neglected disease of modern society. According to WHO, fall is the second major cause of trauma or deaths resulting from unintentional accidents. The aim of this study was to investigate the different types of fall according to International Statistical Classification of Diseases and Related Health Problems 10th Revision (ICD-10) in hospitalized patients visiting specialized accident and trauma hospitals of Mashhad, Iran.Methods:This was a cross sectional retrospective study performed between March 20, 2013 and March 20, 2014. The research population consisted of all medical records of patients for fall injuries in three specialized accident and trauma hospitals. ICD-10 was adopted to categorize all types of falls (w00-w19). The results obtained were analyzed by SPSS 16.Results:Altogether 7,448 cases were included. The codes w18 (fall on same level) and w09 (fall involving playground equipment) with the frequencies of 1,856 and 1,303, respectively in both genders had the maximum number of falls. The maximum percentage of mortality has been related to "fall on and from ladder" ," fall from cliff "and "fall on same level involving ice and snow" .Conclusion:As falls can cause irrecoverable injuries including mortality of people, thus health authorities and policymakers should take preventive measures given the causes of falls and the root of this type of injuries, so that the costs resulting from this cause and its injuries can be reduced.

简介：

简介：Aims:Toinvestigatetheinfluenceofacupunctureoninsulinresistanceinobesitypatients.Methods:Intreatmentgroup,20obesitypatientsweretreatedwithacupunctureofNeiguan(PC6),Zusanli(ST36),Daimai(GB26),Sanyinjiao(SP6),Zhongwan(CV12),etc..Incontrolgroup,12normalvolunteersubjectswereobserved.Theobesityindex,fastingbloodsugar(FPG),plasmainsulin(FINS)andC-peptidecontents,andinsulinsensitiveindex(ISI)weremeasuredbeforeandafteracupuncturetreatment.Results:Beforetreatmentincomparisonwithcontrolgroup,FPG,FINSandC-peptideofobesitypatientsweresignificanthigher(P＜0.01),whileISIwasconsiderablylower(P＜0.01);afteracupuncturetreatment,thelevelsofplasmainsulinandCpeptidedecreasedobviously,ISIincreasedmarkedly(P＜0.01),andtheobesityindexwasconsiderablyimprovedwithatotaleffectiverateof85%.Conclusion:Acupuncturecanalleviateobesityandimproveinsulinresistance.

简介：Objectives:Toevaluateaudiologicalandvestibularfunctionsviabasicaudiologicalevaluation,otoacousticemissionsandvideonystagmography(VNG)invitiligopatients.Materialandmethods:30vitiligopatients(8acrofacialand22mixedtypes)asthestudygroupand30normalhealthyadultsasthecontrolgroupwereincludedinthestudy.Allparticipantsweresubmittedtobasicaudiologicalevaluation,transientanddistortionproductotoacousticemmisions(TEOAEsandDPOAEs),vestibularassessmentincludinghistorytaking,officetestsandvideonystagmography(VNG)anddermatologicalassessmenttodeterminetype,percentofbodysurfaceareainvolvementanddurationofvitiligo.Results:Thisstudyshowedstatisticallysignificantdifferencebetweencontrolandstudygroupsinpuretoneaudiometry(PTA)andotoacousticemissionsresults.Fiftypercentofvitiligopatientshadperipheralvestibulardisorders(10vestibularneuritisand5posteriorcanalbenignparoxysmalpositionalvertigo.Conclusion:Theresultsinthisstudyshowedthat50%ofvitiligopatientssufferedfromperipheralvestibulardisordersinadditiontoauditoryaffection.Vitiligopatientsrequireroutinemonitoringforauditoryandvestibularfunctionsforearlyidentificationandmonitoringofchangesasthediseaseprogress.

简介：Studiesonbrain-evokedpotentialandcontingentnegativevariation(CNV)inmooddisorderremaincontroversial.Todate,noCNVdifferencebetweenunipolarandbipolardepressionhasbeenreported.Brain-evokedpotentialsweremeasuredinthepresentstudytoanalyzeCNVinthreesubtypesofmooddisorder(mania,unipolardepression,andbipolardepression),andtheseresultswerecomparedwithnormalcontrols.Inthemaniagroup,CNVamplitudeBwasgreaterthanincontrols,andthedepressiongroupexhibitedlowerCNVamplitudeBandsmallerA-S'2area,andprolongedpost-imperativenegativevariationlatency.TheCNVcomparisonbetweenunipolarandbipolardepressionfoundthattheprolongedpost-imperativenegativevariationlatencywasonlyinunipolardepression.Theseresultssuggestthatprolongedpost-imperativenegativevariationlatencyisacharacteristicofunipolardepression,andCNVamplitudechangeisastatecharacteristicofmooddisorderpatients.

简介：BACKGROUND:Strokepresentsasatransientorchronicbraindysfunctionandisassociatedwithhighmorbidityandhighmortality.Thedoctorsandscientistswouldliketoarguehowtoenhancethevalidityoftherehabilitationtreatmentandhowtofurtherimprovetheleveloftreatmentonstroke.OBJECTIVE:TheaimofthisstudywastoquantitativelyanalyzethecurrentworldwideprogressinresearchonstrokerehabilitationtreatmentbasedonWebofSciencedatabaseandClinicalTrial.govinthepast10years.METHODS:WeconductedaquantitativeanalysisofclinicaltrialarticlesregardingstrokerehabilitationpublishedinEnglishfrom2003to2013andindexedintheNationalInstitutesofHealthClinicalTrialsregistryandWebofSciencedatabases.DataweredownloadedonMarch15,2013.RESULTS:(1)From2003to2013,2654clinicaltrialsinvestigatingstrokewereindexedinClinicalTrials.gov.Therewereonly58clinicaltrialsregisteredin2003,andtherewasamarkedincreasefrom2005.Atotalof605clinicaltrialsontherehabilitationofstrokewereconductedinthepast10years.(2)TheanalysisshowedthatmostofthetrialsinthefieldwereregisteredbyNorthAmericaninstitutions.WithrespecttotheAsiancountries,ChinaandTaiwanareaofChinaalsopublishedareasonableproportionofthetrials,butcomparativelyspeaking,thenumberoftrialsisreallyrare.Mostoftheinterventionsweredrugs,followedbythedevices,andbehavioralinterventionswererankedthird.(3)Inthepast10years,therewere4052studiesonstrokeindexedbyWebofSciencedatabase.CONCLUSION:Fromperspectiveofresearchprogress,wefoundthatthenumberofclinicaltrialsandpapersonstrokerehabilitationhasincreasedsignificantlyinthepast10years,betweenthemaremarkablepositivecorrelationexists.

简介：Stentsthatkeepweakenedarteriesfromcollapsinghavebeentruelife-savers,butarenolongerneededoncethearteriesarestrengthened.Now,aresearcherhasdevelopedabiodegradablestentforheartpatientswhichwillcarrydrugswherethey'reneededandwillthendissolve.

简介：ThisarticlepresentstheepidemiologicalsurveyofthepatientsatthedispensaryoftheBeijingCapitalAirportfromJuly,1991toJune,1992.Theconstituentratiosofdiseaseandagewereanalyzed.TheresultsofthisstudymaybeprovedhelpfultotheemergencytreatmentatcertainAirports.

简介：为了评估antithyroidantibodie层次，有甲状腺疾病的526个病人和292健康的意义，从Yuci使区域遭到，山西省，中国，被学习。浆液层次为甲状腺荷尔蒙受体抗体(TRAb)被决定，microsomal抗体(TMAb)和thyrogiobulin抗体(TGAb)。在病人之中，为榴状的甲状腺肿和甲状腺腺瘤，坟的疾病，和Hashimoto的甲状腺炎的百分比分别地是44.1%，19.6%和17.7%。到男性的女性的比率是2.0～15.6个.Antibody积极的病人因为TMAb，TGAb和TRAb为Hashimoto的甲状腺炎作为94.6%，76.3%和20.4%可检测，并且40.0%，30.0%和90.3%为格雷夫斯的疾病。为描绘疾病和forusingas的流行病学的基础在结论，在Hashimoto的甲状腺炎和自发的甲状腺机能减退的TGAb/TMAb的在坟的疾病的TRAb的高水平，和那些是有意义的为在单个病人的恶化的预示的指示物。

简介：Auditoryneuropathy(AN)isahearingdisordercharacterizedbyabsenceofauditorybrainstemresponsesdespitepreservationofouterhaircellfunction,andhasattractedattentionsfromresearchersandaudiologistssincereportedbyStarretal[1].ClinicalmanifestationsinANpatientsincludeabnormalauditorybrainstemresponsesnormalotoacousticemissions,lackofacousticreflexeslargecochlearmicrophonics,speechperceptiondeteriora

简介：AIDS曾让我们族及色变，其实正确认识这一病情，积极面对，全社会的人民给予患者关怀，我们就一定会战胜病魔，走向健康！

简介：

简介：Rheumatoidarthritis(RA)isasystemic,autoimmunediseasethatpresentwithintra-articularandextra-articularmanifestations.AuditorysystemmaybeinvolvedduringthecourseofRAdiseaseduetonumbersofpathologies.ThelinkbetweenhearingimpairmentandRAhasbeendiscussedinthepreviousliterature.InthisstudyweprovideanupdateontheclinicalaspectofhearingimpairmentinRA.WesuggesttotesthearinginallnewlydiagnosedRApatientsatdiagnosisaswellasregularlyduringthecourseofdisease.

简介：Comparedwithhighinfectionareasoftheworld,thetotalHIVinfectionrateinChinaisrelativelylow.Nonetheless,becauseofChina'svastterritoryandlargepopulation,thepotentialinfectionriskmustbetakenseriously.Inthenextfewyears,needlesharingamonginjectiondruguserswillremainthemostcommonrouteoftransmissionfortheHIV/AIDSepidemicinChina.Unprotectedsexisgraduallybecomingamajorrouteoftransmission.ChinabegantoimplementHAARTin1999accordingtointernationalstandards.Priorto2003,therewereonlyabout150HIV/AIDSpatientsweretreatedwithHAARTinsomeclinicaltrialsandabout100HIV/AIDSpatientsweretreatedbyprivatesources.ResultsofthosetreatmentsarethescientificbasisfordevelopmentofthetherapeuticstrategiesinChina.InMarchof2003,theChinesegovernmentinitiatedChinaCARESprogram.InNovemberof2003,theChineseMinistryofHealthannouncedanationalpolicyoffreeARVtreatmenttoallHIV+ChinesecitizenswhowereinpovertyandrequiredARVtherapy.Therearetotalof19,456HIV/AIDSpatientsreceivedfreeARVdrugstodatein159regionsand441towns.Currentchallengesarehowtofollow-upandevaluatethosepatientsintheclinicalsettings.Thelongerthetherapyispostponed,themoresideeffectsandthehigherprobabilityofdrugresistancearegoingtooccur.Itremainsunclear,therefore,whenHAARTregimenshouldbestartedintheHIV/AIDSpopulationinChina.

简介：ObjectiveToinvestigatetheeffectoffamilytherapyonprognosisofpatientswithschizophrenis.Method200patientsafterdischargingfromhospitalwererandomlydividedintotwogroups:controlgroup(n=100)andexperimentgroup(n=100).Familytherapywasactualizedinpatientsofexperimentgroup.ResultsTherewassignificantdifferenceinpercentofrecurrenceratebetweencontrolgroup(38%)andexperimentgroup(18%,P<0.05).ConclusionFamilytherapymaydecreaserecurrencerateofschizophrenicafterdischargingfromhospital.

简介：AIM:Tounderstandthecorrelationofserumcholinesterase(CHE)activitywithgastriccancerandtoassesstheirclinicalsignificance.METHODS:ThevelocitymethodwasadoptedtodetecttheactivityofserumCHEinpatientswithgastriccancerandinpatientswithnon-malignanttumorascontrols.RESULTS:TheserumCHEactivityinthetreatmentgroupwassignificantlylowerthanthatinthecontrolgroupwithaverysignificantdifferencebetweenthetwogroups(83.3:113.1,P=0.0003).Agewassignificantlyassociatedwiththeincidenceofgastriccaner.CONCLUSION:SerumCHEactivityhasacloserelationwiththeincidenceofgastriccancer.

简介：AIM:Todelineatethecharacteristicsofthedynamicstereopsistestandanalyzerelatedparametersinintermittentexotropia[X(T)]patients.METHODS:Fifty-sevenX(T)patientsand55normalsubjectswereenrolledinthisstudy.ThenormalandX(T)groupswereusedtotestthereproducibilityandreliabilityofthedynamicstereopsistest,andBangerterfilterswithdensitiesof0.2werethenusedtosimulatesuppressiontotestfortraditionalanddynamicstereopsis.IntheX(T)group,themeasurementsincluded1)dynamicstereopsistestcomprisingthreeparts:motion+disparity,motiononlyanddisparityonly;2)oculardeviationangle;3)Bagolinistriatedlenstest;4)diseasecourse;and5)Titmusstereopsistest.RESULTS:Thetest-retestreliabilityofthedynamicstereopsismethodwas0.901inthenormalandX(T)groups,andnoneoftheX(T)patientswereabletopassthestaticanddynamicstereopsistestsafterusingthe0.2Bangerterfilter.Theaccuracyratewasgreaterthan80%inthenormalgroupand31.81%,36.36%,and45.45%forthemotion+disparity,motion-onlyanddisparityonlycomponentsofthetraditionaltestforX(T)patientsdiagnosedwithstereoblindnessviatraditionaltests,respectively.Patientswithalongdiseasecourse(>1y)hadworsedynamicstereopsisthanthosewithashortdiseasecourse(<1y;P<0.05,Chi-squaretest).Thedeviationanglewasnotcorrelatedwiththemotion+disparity,disparityonly,orthemotion-onlytestcomponents(allP>0.05,Chisquaretest).CONCLUSION:DynamicstereopsisispreservedincertainX(T)patientsdiagnosedwithstereoblindnessviatraditionaltests.AlongdiseasecoursewasshowntobeanegativefactorfordynamicstereopsisinX(T)patientswhichmightbeassociatedwithworseprogression,andprovidegoodreferencesclinically.