简介:Suppose2bagsofpeanutscost59■.Howmuchwill8bagscost?Youcananswerthisquestionbysolvingthefollowingproportion.
简介:Recurrenteventsdataandgaptimesbetweenrecurrenteventsarefrequentlyencounteredinmanyclinicalandobservationalstudies,andoftenmorethanonetypeofrecurrenteventsisofinterest.Inthispaper,weconsideraproportionalhazardsmodelformultipletyperecurrentgaptimesdatatoassesstheeffectofcovaxiatesonthecensoredeventprocessesofinterest.Anestimatingequationapproachisusedtoobtaintheestimatorsofregressioncoefficientsandbaselinecumulativehazardfunctions.Weexamineasymptoticpropertiesoftheproposedestimators.Finitesamplepropertiesoftheseestimatorsaredemonstratedbysimulations.
简介:Thetraditionalproportionalsolenoidhasdisadvantages,suchasbigsizeanddifficultyremoving.Sothispaperintroducesanewtypeofbi-directionalproportionalsolenoid,andexpoundsthestructureandworkingprincipleindetail.Onthisbasis,themathematicalmodeloftheproportionalsolenoidisestablished,anditsoutputcharacteristicisanalyzedbythefiniteelementtoolAnsoft/Maxwell.Itsstructureparameters'influenceontheoutputcharacteristicalsoisdiscussedthroughtheelectromagneticfieldanalysis.Thesimulationresultsshowthatthisnewtypeofbi-directionalproportionalsolenoidcanobtainagoodstaticcharacteristicwithoutthesamemagneticcircuitcontrolofthetraditionalproportionalsolenoid.
简介:Theproblemofdistributedproportionalfairinter-cellfrequencyallocationforflat-structuredcellularsystemsisstudiedinthispaper.Wefirstlyproposeaframeworkofthefrequencyallocationinwhichthewholefrequencyallocationprocessisdecomposedintomanyconsecutivestages,thenidentifythatforeachstagethekeyistofindtheMaximumWeightIndependentSet(MWIS)inagivenweightedconflictgraphinthedistributedmanner.AnewdistributedalgorithmforMWISisdescribedinwhicheachnodeiterativelyexchangesmessageswithneighbors.WiththisdistributedMWISalgorithm,anewdistributedproportionalfairfrequencyallocationschemeispresented.TheperformanceoftheproposedalgorithmistestedincomputerexperimentssimulatingtheLongTermEvolution(LTE)cellularsystems.Simulationresultsshowtheperformanceoftheproposeddistributedproportionalfairfrequencyallocationschemeiscomparablewiththecentralizedones.
简介:TheaimofthisstudyistofindtheexperimentalevidencethattheprecursorfrequencyofalloreactiveCTLsisproportionaltothenumberoftheT-cellepitopespecificities.ThenumberofT-cellepitopespecificitieswasmanipulatedbypulsingdifferentnumberofHLA-A2restrictedpeptide(s)ontotheT2cells,whichactedasstimulatingcellstoelicitallo-reactionbyco-culturingwithperipheralbloodlymphocytes(PBLs)ofHLA-A2negativeindividual.TenHLA-A2restrictedpeptides(allwerenormalcellcomponents)weresynthesized,andcellpeptideextractwaspreparedbyfrozenandthawed.T2cellsloadedwithdifferentnumberofpeptide(s)wereco-culturedwithPBLsofanHLA-A2negativeindividual;thelatterwerestainedwithPKH67inadvance.Thentheproliferationwasmonitoredwithflowcytometry,andtheprecursorfrequencyoftheeffectorcellswasanalyzedbytheModFitSoftware.After6dofculture,noproliferationwasobservedinthebulkcultureofPBLalone,andobviousproliferationtookplacewhenPBLsoftheHLA-A2negativewereco-culturedwithT2cellsloadedwithorwithoutloadingpeptide(s).TheprecursorfrequencyofthealloreactiveCTLswas0.052819forco-culturewithT2cellsloadedwithoutpeptide;howeveritwas0.030429forT2cellswithEBV/LMP2Aand0.030528forT2cellsloadedwithasingleautogeneicpeptide,andincreasedupto0.144942forT2cellsloadedwith10autogeneicpeptides;theprecursorfrequencywas0.203649whenco-culturedwithT2cellsloadedwithmiscellaneouspeptidesextractedfromthecytoplasmofT2cells.ThisstudyrevealsthattheprecursorfrequencyofalloreactiveCTLsisproportionaltothenumberofT-cellepitopespecificities,andindependentofthedensityoftheallogeneicHLAClassⅠmolecule.OurfindingssupportthehypothesisthatthealloreactiveTcellpopulationscomprisemiscellaneousTcellclones;eachisspecifictocorrespondingpMHC.ThenovelconstellationofpeptidespresentedbyallogeneicMHCmoleculesmakesthous
简介:Generalizedcase-cohortdesignhasbeenprovedtobeacost-effectivewaytoenhancetheefficiencyoflargeepidemiologicalcohort.Inthisarticle,weproposeaninferenceprocedureforestimatingtheunknownparametersinCox’sproportionalhazardsmodelingeneralizedcase-cohortdesignandestablishanoptimalsamplesizeallocationtoachievethemaximumpoweratagivenbudget.Thefinitesampleperformanceoftheproposedmethodisevaluatedthroughsimulationstudies.TheproposedmethodisappliedtoarealdatasetfromtheNationalWilm’sTumorStudyGroup.
简介:在他们被发射到市场以前,公司屏蔽新产品工程是极其重要的。到目前为止,许多途径为处理屏蔽产品革新的过程被开发了。由于不明确、含糊、不完全的信息以及考虑到新产品开发(NPD)的动态地复杂的过程,一条模糊语言学途径采用了语言学评价和fuzzy-set-based计算为屏蔽新产品是合理的。然而,如此的一条模糊语言学途径面对各种各样的缺点和限制,例如信息的损失,在考虑与不明确的主观判断等等上的人性有关的方面失败。这些缺点和限制导致窘境,即,它的对很困难相当并且精确屏蔽新产品工程。在这份报纸,我们建议比例的3元组的一个观点表示一个语言学评价和相关忽略信息,和为语言学评价的统一的保存偏爱的比例的3元组转变由在二个不同语言学术语集合之间的比例的3元组代表了。在这个基础上,为屏蔽新产品的模糊语言学表示模型投射的比例的3元组被开发。建议模型是灵活的处理与屏蔽新产品工程有关的不明确、含糊、不完全的信息,这被显示出。它不仅允许计算程序与不同信心层次表示他们的主观判断,而且也能处理不完全的语言学评价。最终,建议模型也改进屏蔽结果的精确和reasonability。
简介:Withtheobjectiveoftakingfulluseofchannelresource,weproposedtwoutilitybaseddynamicsubcarrierallocation(DSA)algorithmsforthesinglecarrierfrequencydivisionmultipleaccess(SC-FDMA)system,whicharetheproportionalfairfrugalityconstrained(PF-FC)algorithmandtheweightedproportionalfairfrugalityconstrained(WPF-FC)algorithm.Thetwoproposedalgorithmsaredesignedunderthefrugalityconstraint(FC)controlconsiderationsoastoavoidserviceratewasteandimprovethespectrumefficiency.Moreover,thequeuingbuffermodelinthispaperisestablishedonafinitesizestructureratherthanthetraditionalinfinitequeuingmanner,whichismoreconsistentwiththepracticaltransmissioncondition.Simulationresultsindicatethatthetwoproposedalgorithmscanbothachievesignificantlybettersystemrate-sumcapacityandqualityofservice(QoS)performancethantheirprimaryalgorithms,andaremoreapplicablefortheheterogeneoustraffic.