简介：AIMTo评估热门non-steroidal的预防管理的功效在糖尿病的病人的有斑点的浮肿追随者奔流外科上的反煽动性的药(NSAID)，并且在NSAID的类型之间比较(ketorolactromethamine0.4%并且nepafenac0.1%).METHODSGroup(控制)1作为一个安慰剂组接待了人工的眼泪代用品，(nepafenac)组2收到了热门nepafenac(ketorolac)0.1%，和组3收到了热门ketorolactromethamine0.4%。病人们在完成一个以后手术后地被检查为评估似胞的有斑点的浮肿(CME)的星期，一个月，二个月和三月间隔开发。主要学习结果在与光连贯地形学(10月)测量的中央有斑点的厚度(CMT)正在完成最好改正的视觉尖酸(BCVA)和变化76个病人的.RESULTSEighty眼睛在这研究被包括。BCVA在第三个月显示出统计上重要的差别手术后列在后面在上面在控制组和NSAID组(P=0.04)之间。在开始从的所有情况中的CMT有增加手术后第一个星期直到第三个月。CMT显示出控制组和NSAID组之间的统计上重要的差别从手术后第一个月直到第三个月(P=0.008，0.027，0.004)。在BCVA和外科手术前的10月CMT.CONCLUSIONProphylacticnepafenac和ketorolac组之间没有统计上重要的差别，手术后的NSAID可以在在跟随奔流外科的糖尿病的眼睛减少CME的频率和严厉有一个角色。

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简介：Rheumatoidarthritis(RA)isasystemic,autoimmunediseasethatpresentwithintra-articularandextra-articularmanifestations.AuditorysystemmaybeinvolvedduringthecourseofRAdiseaseduetonumbersofpathologies.ThelinkbetweenhearingimpairmentandRAhasbeendiscussedinthepreviousliterature.InthisstudyweprovideanupdateontheclinicalaspectofhearingimpairmentinRA.WesuggesttotesthearinginallnewlydiagnosedRApatientsatdiagnosisaswellasregularlyduringthecourseofdisease.

简介：AIMTo把主要、周期性的pterygium外科的长期的结果与三种不同技术作比较：联合结膜自体移植和覆盖羊膜的膜移植(有AMT的猫)，结膜自体移植移植(猫)独自一个、羊膜的膜移植(AMT)alone.METHODSIn这回顾的研究，142个pterygium病人的142只眼睛(104主要，38周期性)经历了猫(组A)，AMT(组B)或有AMT(组C)的猫分别地后面的外科的切除基于复发和手术后的complications.RESULTSThe数字被考察并且比较一样的描述在下面)，18(10，8)并且2(1，1)在组A，B，和C分别地；干燥眼睛是22(16，6)，27(18，9)并且7(3，4)；结膜发炎是30(17，13)，27(16，11)并且11(6，5)。在组C(主要或周期性的任何一个或两个)的病人主要在组A或B比那些显示出显著地更好的结果(P<0.05)关于上述临床的effects.CONCLUSIONCombined猫并且过分AMT比猫或AMT为主要、周期性的pterygium外科有复发和手术后的复杂并发症的显著地更低的率独自一个。

简介：AIMTo评估剩余的excimer激光修正的功效和安全在有intraocular的奔流抽取以后的折射错误透镜(IOL)培植在不平常cases.METHODSTotally有高剩余的24个病人在有IOL培植的奔流外科以后的折射错误被检验。22个病人有phacoemulsification和IOL培植的历史，并且二与IOL培植有囊外的奔流抽取。外科手术前的医药记录的详细检查被做解释奔流以后的折射错误的起源。所有病人经历了photorefractirekeratectomy(PRK)改进。吝啬的结果措施是折射，uncorretted视觉尖酸(UCVA)，最好改正的视觉尖酸(BCVA)和角膜的透明性并且列在后面在上面从1到剩余变常眼的8y.RESULTSThe主管原因是在有高近视和先天的透镜畸形的反常眼睛的不精确的IOL计算，两个都由角膜的散光列在后面导致的缝术并且先存在。在奔流外科以后并且在激光改进前，吝啬的球形的等价物(SE)是-0.56?潢吗？

简介：AIMToprovideanupdatedassessmentofthesafetyandefficacyofenhancedrecoveryaftersurgery(ERAS)protocolsinelectivegastriccancer(GC)surgery.METHODSPubMed,Medline,EMBASE,WorldHealthOrganizationInternationalTrialRegister,andCochraneLibraryweresearcheduptoJune2017forallavailablerandomizedcontrolledtrials(RCTs)comparingERASprotocolsandstandardcare(SC)inGCsurgery.ThirteenRCTs,withatotalof1092participants,wereanalyzedinthisstudy,ofwhom545underwentERASprotocolsand547receivedSCtreatment.RESULTSNosignificantdifferencewasobservedbetweenERASandcontrolgroupsregardingtotalcomplications(P=0.88),mortality(P=0.50)andreoperation(P=0.49).Theincidenceofpulmonaryinfectionwassignificantlyreduced(P=0.03)followinggastrectomy.However,thereadmissionrateafterGCsurgerynearlytripledunderERAS(P=0.009).ERASprotocolssignificantlydecreasedthelengthofpostoperativehospitalstay(P<0.00001)andmedicalcosts(P<0.00001),andacceleratedbowelfunctionrecovery,asmeasuredbyearliertimetothefirstflatus(P=0.0004)andthefirstdefecation(P<0.0001).Moreover,ERASprotocolswereassociatedwithalowerlevelofseruminflammatoryresponse,higherserumalbumin,andsuperiorshorttermqualityoflife(QOL).CONCLUSIONCollectively,ERASresultsinacceleratedconvalescence,reductionofsurgicalstressandmedicalcosts,improvednutritionalstatus,andbetterQOLforGCpatients.However,high-qualitymulticenterRCTswithlargesamplesandlong-termfollow-upareneededtomorepreciselyevaluateERASinradicalgastrectomy.

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简介：AIMTo在一年后续上分析并且比较五个不同变量(1wk，1，3，6并且12mo)：线性测密度术珍视的前面的囊(交流)，和以后的囊(PC)区域测密度术值，交流和PC，和交流洞在femtosecond以后的区域减小比率帮助激光的奔流surgery.METHODSThis是未来的比较级学习。71个病人经历了femtosecond在2014年6月和2015年12月之间的单个眼睛上的帮助激光的奔流外科。5.0公里直径激光帮助了前面的capsulotomy在所有眼睛上被执行。在每外科以后的评估，交流opacificaction(ACO)和密度铺平的PCopacification(PCO)被OculusPentacam?HR使用区域和线性测密度术方法。数字图象与一个裂缝灯Topcon摄影照相机和IMAGEnet?被捕获5软件。数字图象上的交流洞区域用Sketchandcalc区域计算器被测量并且变换成减小比率levels.RESULTSUsing皮尔森关联系数(PCC)，我们没发现关联(r=-0.091，P=0.46)在在ACO的进化之间的第12个月评价，区域测密度术珍视，PCO区域测密度术珍视看作了独立变量。我们没发现关联，用PCC(r=-0.096，P=0.43)在ACO线性测密度术价值和PCO的进化之间，线性测密度术珍视在第12月访问，作为独立变量两个都工作。交流线性测密度术层次和交流区域测密度术层次继续从第六强烈成长到第12个月。交流空缺区域减小比率的价值的分析(1wk，1，3，6，12mo)揭示了连续考试的价值之间的统计上重要的差别，但是变化的大小减少了。在在六和12之间监视月的最后的时期，变化的大小是结果显示出的low.CONCLUSIONOur当capsulorhexis区域减小比率铺平时，ACO测密度术从第六珍视到第12个月的Scheimpflug的猛烈增加显示了可观的减少。我们没发现在ACO区域和PCO区域和线性测密度术价值之间的关联，在第12月考试，作为独立变量工作。

简介：Objectives:Facialnerveaberrationisthemosttroublesomesituationincongenitalmalformationsofmiddleear.Theaimofourstudyistoinvestigateitsimagingandclinicalfeaturesaswellasrelevantchoiceofsurgicaltechniquesforhearingimprovement.Methods:Aretrospectivestudyinvolvingreviewofclinicaldataof227patients(256ears)withcongenitalmiddleearanomalywasundertaken,includingpreoperativecomputedtomography(CT)data,surgicalrecordsandvideos.Results:Aberrationinvolvingintratemporalfacialnervewasfoundin82/256ears(32.03%)withcongenitalmiddleearanomaly.Themostcommonformsofaberrationincludedoverhangingovertheovalwindow(50/82ears,60.98%),bifurcation(3/82ears,3.66%)andtransverseoverthepromontory(3/82ears,3.66%),countingfor68.29%(56/82)ofthecaseswithfacialnerveaberration.Concomitantstapesmalformationwasfoundin76/82ears(92.68%)andatresiaorstenosisoftheovalwindowin27/82ears(32.93%).In9/82ears(10.98%)bothstapesandovalwindowwasabsent.Electivesurgeriesforthepurposeofhearingimprovementincludedstapodotomy+pistonimplantation,labyrinthotomy,labyrinthotomy+totalossicularreplacementprosthesis(TORP)implantationandVibrantSoundbridge(VSB)implantation.Conclusion:Themajorityoffacialnerveaberrationincongenitalmalformationofmiddleearinvolvesdisplacementoffacialnerve,inadditiontoconcomitantmalformationsofthestapesand/orovalwindow,whichmayinfluencethechoiceofsurgeryforhearingimprovement.VSBimplantationmaybeconsideredasausefuloption.

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简介：Objective:EvaluatingtheauditoryfunctioninpatientswithchronichepatitisCtreatedwithsofosbuvirandribavirin.Methods:Thisstudyinvolved80patientswithchronichepatitisCwhoagreedtoreceivesofosbuvirandribavirin.Allparticipantsweresubjectedtobaselineotologicalandaudiologicalassessmentjustbeforetreatment.Theaudiologicalassessmentincludedstandardpuretoneaudiometry,extendedhighfrequencyaudiometry,immitancemetryandotoacousticemissions(OAEs)(transientanddistortionproduct).Accordingtobaselinehearingthresholdmeasurements,thestudypopulationwasdividedinto2groups.Group1included42patientswithnormalhearingsensitivity(250e8000Hz),andGroup2included38patientswithsensorineuralhearingloss.After24weeksoftherapy,otologicalandaudiologicalassessmentswererepeatedandcomparedbetweenthetwogroupsandbeforeandaftertherapy.Results:Post-treatmenthearingthresholdevaluationshowednosignificantdifferencefrompretreatmentevaluationatalltestedfrequencies.Therewasnostatisticallysignificantdifferencebetweenpreandpost-treatmentotoacousticemissionsresults.Conclusion:TherapywithsofosbuvirandribavirininchronichepatitisChasnonoticeableeffectsoncochlearfunctions.

简介：AIMTo评估人的透镜上皮房间apoptosis并且对femtosecond激光在有到N3的N2的帮助奔流外科(FLACS).METHODSSixty奔流病人根据LOCSIII上演的femtosecond激光导致的间充质的转变(EMT)上皮在这研究被注册并且随机把组划分了成三：FLACS1组(由有LenSx的FLACS的奔流外科)，FLACS2组(由有LensAR的FLACS的奔流外科)和用手的组(由phacoemulsification的奔流外科)。在二个FLACS组的病人由LenSx或LensAR激光系统执行了前面的capsulotomy。在用手的组的病人被执行连续曲线的capsulorrhexis(CCC)手工地。恰好在从眼睛移动了以后，前面的囊被修理。在奔流surgery.RESULTSThe囊优势被病理学的染色在用手的capsulotomy在二个FLACS组和光滑的边看不规则和粗糙以后，染色的Hematoxylin-eosine，immunofluorescence染色和即时PCR被执行以便观察人的透镜上皮房间变化。有部分肿、破坏的原子核的房间配置的不规则在二个FLACS组被观察。Femtosecond激光能比手工地执行的CCC在人的透镜上皮房间导致显著地更高的房间apoptosis(P<0.05)。透镜上皮房间apoptosis根据皮尔森关联分析与femtosecond激光持续时间被相关。在二个FLACS组的减少的N-cadherin表示，alpha-SMA和FSP-1水平证明房间EMT.CONCLUSIONFemtosecond激光的抑制可以影响在剥的中央透镜囊下面的透镜上皮房间的apoptosis和EMT。

简介：Applicationofsurgicalendoscope,usedaloneorincombinationwiththesurgicalmicroscope,fortheoperativemanagementofearandtemporalboneconditionsmayallowimprovedaccessandclearanceofdisease.Preservationofnormalstructuresmayalsobeimproved.Astheuseofthistoolisincreasing,theneedforbetterunderstandingoftheanatomyoftheearisbecomingevident.Thisisparticularlysoforendoscopicsurgeryaimingatremovaloflesionsinvolvingtheinfra-cochlearcorridorand/orpetrousapex.Humantemporalbone-derivedlabyrinthcasts(molds),originallymadeforendolymphaticductandsacanalysiswhichgenuinelyrepresentthemembranouslabyrinthanditsadjacentsofttissues,weremorphometricallyanalyzedintermsoftheanatomicrelationsbetweenstructuresinandaroundtheinfra-cochlearcorridor.Thedistancebetweenthepetrouscarotidartery(PCA)andthebasalturnofthecochlea,thedistancebetweenPCAandinfra-cochlearvein(ICV)/cochlearaqueduct(CA),andthedistancebetweenthelowersurfaceofbasalcochlearturnandthepointwherethecarotidarteryandjugularvein(JV)meetclosetothejugularforamen,weremeasuredtobearound1.3mm,6mmand8mmrespectively,thusconstitutinganapproximate68mm2infra-cochlearcorridor.Thisanalysisandfurtherstudywithlargersamplesmightbehelpfulforoperationviathiscorridorledtothepetrousapexwherecholesterolgranuloma,cholesteatomaandotherlesionsarenotuncommon.

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简介：Objective:Hepatocellularcarcinoma(HCC)isacommonmalignancyassociatedwithhighmorbidityandmortalityratesworldwide.EarlydiagnosisplaysanimportantroleintheimprovementofHCCprognosis.Methods:Inthisstudy,weconductedacomprehensiveanalysisofHCCDNAmethylationandgeneexpressiondatasetsinTheCancerGenomeAtlas(TCGA),toidentifyaprognosticsignatureforHCCdiagnosisandsurvivalprediction.First,weidentifieddifferentialmethylationCpG(dmCpG)sitesinHCCsamplesandcomparedthemwiththoseinadjacentnormallivertissues;thiswasfollowedbyunivariateanalysisandSureIndependenceScreening(SIS)inthetrainingset.Therobustnessoftheidentifiedprognosticsignaturewasevaluatedusingthetestingset.ToexplorethebiologicalprocessesinvolvedinHCCprogression,wealsoperformedfunctionalenrichmentanalysisforoverlappinggenesbetweengenescontainingdmCpGsites(DMGs)anddifferentialexpressiongenes(DEGs)inHCCpatients,usingdatafromtheDatabaseforAnnotation,Visualization,andIntegratedDiscovery(DAVID).Results:Asaresult,weidentifiedfiveCpGsitesthatweresignificantlyassociatedwithHCCsurvivalthroughunivariateanalysisandSIS.Univariateanalysisofclinicalcharacteristicsidentifiedageandriskfactors(includingalcoholconsumptionandsmoking)asindependentfactorsthatindicatedHCCsurvival.Multivariateanalysisindicatedthattheintegratedprognosticsignature(weightedcombinationofthefiveCpGsites)thattookageandriskfactorsintoconsiderationresultedinmoreaccuratesurvivalprediction.Conclusions:ThisstudyprovidesanovelsignatureforpredictingHCCsurvival,andshouldbehelpfulforearlyHCCdiagnosisandpersonalizedtreatment.

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