简介：

简介：

简介：这份报纸由利用连续辅助covariate信息当主要covariate仅仅为随机选择的subsample被查明时，改进统计推理的效率认为添加剂危险回归是分析。作者为回归参数构造一个基于鞅的估计方程并且建立asymptotic一致性和结果的评估者的规度。模拟学习证明建议方法罐头极大地与在许多背景丢弃辅助covariate信息的评估者相比改进效率。一个真实例子也作为一幅插图被提供。

简介：前列腺癌症预防选拔赛(PCPT)是泌尿学的领域里的精液的研究。在它的起始的出版以后的超过10年，从这试用的更新的数据继续塑造我们前列腺癌症的理解。一旦想了在正常范围，在从PCPT的主要调查结果之中是前列腺癌症在有前列腺特定的抗原(PSA)的人是普通的示范，1finasteride阻止良性的prostatic肥大的发展，2它而且增加PSA3和数字直肠的examination.4的敏感PCPT帮助建立在可勃起的机能障碍和心血管的疾病之间的连接，5并且也许，最重要地，finasteride表明了25%相对风险reduc

简介：Injurytoaxonsclosetotheneuronalbodiesinthemammaliancentralnervoussystemcausesalargeproportionofparentingneuronstodegenerate.Itisknownthatopticnervetransectionclosetotheeyeinrodentsleadstoalossofabouthalfofretinalganglioncellsin1weekandabout90%in2weeks.Usinglowlevellasertreatmentinthepresentstudy,wedemonstratedthattreatmentwithhelium-neon(660nm)laserwith15mWpowercoulddelayretinalganglioncelldeathafteropticnerveaxotomyinadulthamsters.Theeffectwasmostapparentinthefirstweekwithashortperiodoftreatmenttime(5minutes)inwhich65–66%ofretinalganglioncellssurvivedtheopticnerveaxotomywhereas45–47%ofretinalganglioncellsdidsoinopticnerveaxotomycontrols.Wealsofoundthatsingledoseandearlycommencementoflaserirradiationwereimportantinprotectingretinalganglioncellsfollowingopticnerveaxotomy.Thesefindingsthusconvincinglyshowthatappropriatelasertreatmentmaybeneuroprotectivetoretinalganglioncells.更多还原

简介：Objective:Toassesstheclinicalfeatures,survivalandprognosticfactorsofprimarytesticulardiffuselargeB-celllymphoma(DLBCL).Methods:Aretrospectivestudyof37patientswithprimarytesticularDLBCLwascarriedoutfromNovember2003toMay2012.Theirclinicalfeatures,survivalandprognosticfactorswereanalyzed.Results:Duringamedianfollow-upperiodof39.8months(5.4-93.0months),themedianprogression-freesurvival(PFS)was26.2months(95%CI:0-65months)andthe3-yearoverallsurvival(OS)ratewas78.4%.Withinthewholecohort,thefactorssignificantlyassociatedwithasuperiorPFSwerelimitedstage(stageI/II),lactatedehydrogenase(LDH)≤245U/L,internationalprognosticindex(IPI)≤1,primarytumordiameter<7.5cm,andpatientswhohadcompleteresponse(CR)andreceiveddoxorubicin-containedchemotherapy(P<0.05).Therewasatrendtowardsuperioroutcomeforpatientswhoreceivedcombinedtherapy(surgery/chemotherapy/radiotherapy)(P=0.055).PatientswhohadCR,primarytumordiameter<7.5cmandIPIscore≤1weresignificantlyassociatedwithlongerPFSatmultivariateanalysis.Conclusions:PrimarytesticularDLBCLhadpoorersurvival.CR,primarytumordiameterandIPIwereindependentprognosticfactors.Thecombinedtherapyoforchectomy,doxorubicin-containedchemotherapyandcontralateraltesticularradiotherapy(RT)seemedtoimprovesurvival.

简介：Allorejection为成功的机关移植仍然是一个障碍。尽管抑制免疫力的代理人的不同类型为控制拒绝并且延长接枝幸存是有效的，因为副作用和毒性，药治疗被限制。因此，为导致allotolerance识别新候选人药必要、迫切。最近，细菌的flagellin在vitro在人导致规章的T房间(Tregs)的抑制免疫力的活动，这被报导了。在现在的学习，我们在allograft幸存上分析了recombinantflagellin(rFliC)的效果并且探索了在一个鼠科的皮肤allotransplantation模型与接受者Tregs的激活联系的内在的机制。结果显示出那个rFliC政府(3mg/kg每为3天的天，i.p)延长allograft幸存(吝啬的幸存时间：18.4±；1.1days)与控制组相比(10±；0.7days，P<；0.01)。另外，像使用费的受体的更高积极的表示(TLR5)5在与rFliC管理的allograft以内被检测。CD4+CD25+Foxp3+Tregs；Treg相关的因素TLR5的表示，Foxp3，TGF-β；1并且IL-10；并且Tregs的增长和抑制被增加与控制相比跟随rFliC管理。而且，忍耐相关的分子的增加的表示和rFliC导致的Tregs的增长被在vivo并且在vitro堵住抗体的anti-TLR5稀释。在结论，rFliC管理延长allografts的幸存，它以一种TLR5依赖的方式与接受者Tregs的激活被联系。rFliC可以是anti-allorejection治疗的一个新候选人。

简介：Molecularsubtypingofbreastcancermayprovideadditionalprognosticinformationregardingpatientoutcome.Theepidermalgrowthfactorreceptor(HER2)overexpressingbreastcancersaredesignatedasHER2-postive(HER2+)breastcancerandcarryaparticularlyunfavorableprognosis.WepresenttwocasesofHER2-postivemetastaticbreastcancer(MBC)whoarefoundtobeachallengetotreat,especiallyduetotheoccurrenceofbrainmetastasis.Trastuzumab-basedtherapyimprovesclinicaloutcomes,evenifthepatienthasundergonemulti-linetreatment.ThesecasereportsalsoemphasizetheimportanceofretestingHER2statusbecauseitcanbediscordanceinreceptorstatusbetweenprimaryandrecurrentbreastcancer.

简介：Objective:Toevaluatetherelationbetweenargyrophilicnucleolarorganizerregion(AgNOR)-associatedproteinsandclinicopathologicalparametersandsurvivalinnon-small-celllungcancer(NSCLC).Methods:Atotalof207surgicalspecimensdiagnosedasNSCLCwereincludedinthisstudy.Double-stainingprocedureswereperformedusingantigenKi-67(cloneMIB-1)andsilvernitratebyimmunohistochemicalandAgNOR-stainingmethods.Results:TheAgNORareainMIB-1-positivecellsofNSCLCisrelatedtoclinicopathologicalparametersundertheTNM(tumor,node,andmetastasis)system.ThesurvivalofpatientswithsmallAgNORareainMIB-1-positivecellsisbetterthanthatofpatientswithlargeAgNORarea.Molecular,biological(AgNORareainMIB-1-positivecells),andclinicopathological(greatesttumordimension,metastasestoregionallymphnodes,histology,anddifferentiation)parametersareindependentprognosticfactorsofNSCLC.Conclusion:TheAgNORareainMIB-1-positivecellsisrelatedtoclinicopathologicalparametersandsurvivalinNSCLC.