简介：Sillsarecormnon;communityscreeningstudiesintheUKhaveshownprevalencesofabout10%forChlamydiaand12%forgenitalherpes.Inwomen,themorepotentiallyseriousinfectionssuchasgonorrhoeaandChlamydiaareoftenasymptorrkatic,whereasthepresenceofsymptormsuchasvaginaldisclmrgegenerallyindicatesalesspathogenic(bu!stillpotentiallydebilitating)infectionsuchasCandida.SHsareoftenmultiple,andthefindingofoneinfectionshouldpromptconsiderationoftestingforothers.

简介：Theprimarysymptomsofrespiratorydisordersarebreathlessness,chestpainandcough,whichmaybeassociatedwithsputumproduction.However,disordersofthelungscanproducedistantsymptoms(e.g.non-metastaticmanifestationsoflungcancer),andnon-respiratoryconditionssuchasanaemiaandmetabolicacidosscancauseberathlessness.Adequateassessmentofanypatientrequiresafullclinicalhistoryandexamination.Thiscontributionconsidersaspectsdirectlyrelevanttotherespiratorysystem.

简介：Symptotm:thefollowingsymptoms,volunteeredbythepatientorelicitedthroughspecificenquiry,mayindicatethepresenceofanSTI.

简介：ObjectiveTostudyconcomitantsymptomsanddiseaseconditionsinsuddendeafness.MethodsClinicaldataof418casesofsuddendeafnesstreatedinthisdepartmentfrom2000to2007werereviewed.ResultsOfthe418cases,201weremalesand217werefemales.Rightearwasinvolvedin184casesandleftearin191cases.Bilateralinvolvementwasseenin43cases.Theaverageagewas44.1years.Tinnituswasreportedin369cases(88.3%)eitherbeforeorafterhearingloss,ofwhich64.5%wasoflowpitch,27.1%ofhighpitchand8.4%ofmixedtones.Constanttinnituswasreportedin83%ofthecases,andmuffledfeelingsin33.3%ofthecases.Hearinglosswastheonlycomplaintin221cases(52.9%).Dizzinesswasreportedin77cases(18.4%)andvertigoattacksin120cases(28%).Hypertension,coronaryarterydiseaseanddiabeteswerefoundin19.6%of418casesandhyperlipidemiain54.5%of211cases.CTand/orMRIdatawereavailablein147cases,withpositivefindingsin18cases(12.3%):2withacousticneuroma(1.36%);4withemphraxisinthebasalganglia,cerebellum,temporallobeorparietallobe,and12withpoorpneumatizationofipsiorcontralateralmastoidcells.ConclusionInthiscaseseriesofsuddendeafness,low-pitchconstanttinnituswasacommoncomplaint.Mostofthestudiedcasespresentedwithsimplehearingloss.Vertigoattacksweremorecommonthandizzinessinthisgroupofpatients.Themostcommonconcomitantdisorderwashyperlipidemia,especiallyhightriglycerides.Imagingstudiesareimportantinmanagingsuddendeafnessinrulingoutacousticneuromaandotherintracranialdiseases.

简介：OnMay7,2012,VladimirPutinwassworninaspresidentoftheRussianFederation.ForPutin,itnotonlymarkedachangefromthePrimeMinistershiptothePresident.Thechangecameatatimeofunprecedentedproblemsandchallenges.

简介：AIM:Toexaminefamilialaggregationofirritablebowelsyndrome(IBS)viaparentalreinforcement/modelingofsymptoms,coping,psychologicaldistress,andexposuretostress.METHODS:Mothersofchildrenbetweentheagesof8and15yearswithandwithoutIBSwereidentifiedthroughtheGroupHealthCooperativeofPugetSound.Motherscompletedquestionnaires,includingtheChildBehaviorChecklist(childpsychologicaldistress),theFamilyInventoryofLifeEvents(familyexposuretostress),SCL-90R(mo...

简介：Mostadultswithauditoryprocessingdisorder(APD)oftenhavetroubleatwork.ItispossiblethattheselisteningproblemsinadultswithAPDinfluencetheirmentalhealth.Thus,wehavetotakethesubject'spersonalityandmentalstatusintoconsiderationwhensupportingsubjectswithAPD.However,studiesonAPDinadultsarecomparativelyrare.Inthisstudy,weaimedtoevaluatetherelationshipsbetweentheresultsofauditorytests,APDsymptoms,andpsychologicalstatusinsubjectswithAPD.Thisstudyincluded22adultswhocomplainedoflisteningproblemsineverydaylife,andtheyunderwentauditoryprocessingtestsandwerequestionedregardingtheirpsychologicalcharacteristics.Fromtheresultsoftheauditoryprocessingtests,allsubjectsshowedlowscoresonatleastonetest;therefore,theyweresuspectedofhavingAPD.Especially,thescoreswerelowontheauditorymemorytest.Furthermore,subjectswithAPDshowrelativelysimilarpsychologicalcharacteristicstoeachother.However,therewasnosignificantrelationshipbetweentheresultsoftheauditoryprocessingtestsandpsychologicalcharacteristics.Wehavetotakenoticeofasubject'spsychologicalstatewhentheyperceivetheirlisteningdifficultiesasalarge-scaleproblemandfeelanxiousasaresult.Forthispurpose,weshouldtakepsychologicalcharacteristicsintoconsiderationatthetimeofthemedicalexaminationinterviewbeforeaudio-psychologicaltesting.

简介：我们决定了在prostatic演算和更低的尿道之间的关联症状(LUTS)，以及prostatic演算的预先安排的因素。为LUTS在我们的诊所介绍了的1527个病人，802经历了完全的评估，包括transrectalultrasonography，voidedbladder-3标本和国际prostatic症状分数(IPSS)。有prostatic演算的335个病人和没有prostatic演算的467个病人的一个总数分别地被划分成演算和没有演算组。严重LUTS和prostatic演算的预兆的因素用uni/multivariate分析被决定。全面IPSS分数是15.7卤9.2在演算和没有演算组织的9.2和14.1卤，分别地(P=0.013)。最大的流动率是12.1卤6.9和14.2卤8.2mLs?1在演算和没有演算组织，分别地(P=0.003)。在为预言严重LUTS的因素的univariate分析上，在年龄的差别(P=0.042)，prostatic演算(P=0.048)并且前列腺炎(P=0.018)是统计上重要的。在multivariate分析上，然而，没有因素是重要的。在为预先安排的multivariate分析上prostatic演算的因素，在年龄的差别(P<0.001)并且前列腺体积(P=0.001)是重要的。到我们的知识，有prostatic演算的病人抱怨更严重的LUTS。然而，prostatic演算不是严重LUTS的一个独立预兆的因素。因此，不仅因为prostatic演算而且因为年龄和另外的因素，有prostatic演算的人有更严重的LUTS。另外，老年和大前列腺体积是为prostatic演算的独立人士预先安排因素。

简介：我们在朝鲜良性的prostatic增生(BPH)在更低的尿道症状(LUTS)上分析了肥胖的效果病人。这是multicenter，在朝鲜在四个中心进行的代表性的、未来的学习。有对BPH第二等的LUTS的602个人的一个总数被包括。BPH/LUTSs盒子是有8削尖的国际前列腺症状分数(IPSS)的40年的人。高度，重量和腰圆周被测量。在602个病人之中，156个病人在90厘米上面有腰圆周，代表中央肥胖，并且215个病人在25kgm-2上面有一个身体团索引。腰圆周断然与前列腺体积被相关(P=0.034)。有腰圆周的人>90厘米富有经验1.36褶层与腰圆周90厘米与人相比增加了严重LUTS(95%CI0.82鈥?.41)的风险。前列腺体积断然与中央肥胖在人与紧急和nocturia被相关。在与BPH诊断的朝鲜的人的这张人口，中央肥胖而非全面肥胖似乎是LUTS的更重要的预言者与BPH相关。

简介：MemorylossandmentalconfusionarethefirstovertsignsofAlzheimer'sDisease,anincurableandfatalbrainailment.Butscientistsarestartingtofindevidenceofthediseaselongbeforesymptomsappear.

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简介：Background:NostudieshavecomparedeffectivenessofresistancetrainingandTaiJiexerciseonrelievingsymptomsofkneeosteoarthritis(OA).Thepurposeofthestudywastoevaluateeffectsofa10-weekTaiJiandresistancetraininginterventiononimprovingOAsymptomsandmobilityinseniorswithkneeOA.Methods:Thirty-oneseniors(60-85years)wererandomlyassignedtoaTaiJiprogram(n=12),aresistancetrainingprogram(n=13),andacontrolgroup(n=6).AllparticipantscompletedtheWesternOntarioandMcMaster(WOMAC)OsteoarthritisIndexandperformedthreephysicalperformancetests(6-minwalk,timed-up-and-go,andtimedstairclimbanddescent)beforeandafterthe10-weekintervention.Results:Theparticipantsintheresistancetraininggroupsignificantlyimprovedonthetimed-up-and-gotest(p<0.001),theWOMACpainsubscore(p=0.006),WOMACstiffnesssub-score(p<0.001),andWOMACphysicalfunctionsub-score(p=0.011).TheTaiJigroupsignificantlyimprovedonthetimed-up-and-gotest(p<0.001),butnotontheWOMACscores.Conclusion:ResistancetrainingwaseffectiveforimprovingmobilityandimprovingthesymptomsofkneeOA.TaiJiwasalsoeffectiveforimprovingmobility,butdidnotimprovekneeOAsymptoms.

简介：AbstractImportance:Tics usually start around 4-6 years old and affect about 1% of school-age children. Premonitory urges (PUs) are sensory phenomena that precede tics and are often described as unpleasant feelings. Recent evidence supports a relationship between PUs and tic severity, but reports are conflicting. In addition, there is no report of PUs in the Chinese population.Objective:To investigate the correlation between PUs and tic symptoms in the Chinese population with tic disorders.Methods:We recruited 252 Chinese individuals with chronic tic disorders (age 5-16 years). The Yale Global Tic Severity Scale (YGTSS) was used to assess tic symptoms, and the Premonitory Urge for Tics Scale (PUTS) was used to assess PUs. We calculated Spearman correlations between PUTS and YGTSS scores, and constructed a linear regression model to predict the tic symptom severity by PUs.Results:There was a significant positive correlation between PU severity (PUTS scores) and motor tic severity, total tic severity, tic-caused impairment (YGTSS scores) (P < 0.05). PU severity was a significant positive predictor of tic symptom severity (standardized beta coefficient = 0.174, t = 2.786, P = 0.006).Interpretation:We provide evidence for a correlation between PUs and tic symptoms. PU severity predicts tic symptom severity. Further research on PUs is needed to clarify the shared brain mechanism with tics, and their role in tic expression. A suitable tool to assess PUs in younger children is also needed.

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简介：Theepidemiologyofbenignprostatichyperplasia(BPH)andmalelowerurinarytractsymptoms(LUTS)hasevolvedconsiderablyduringthepastseveralyears.ThetermLUTSdescribesadistinctphenotypeandallowsforabroadepidemiologicdescriptionofurinarysymptomsatapopulationlevel.Althoughitisbecomingthepreferredtermforstudyingurinarysymptomsinpopulations,LUTS

简介：AbstractBackground:Sleep disorders are common but under-researched symptoms in patients with multiple system atrophy (MSA). We investigated the frequency and factors associated with sleep-related symptoms in patients with MSA and the impact of sleep disturbances on disease severity.Methods:This cross-sectional study involved 165 patients with MSA. Three sleep-related symptoms, namely Parkinson’s disease (PD)-related sleep problems (PD-SP), excessive daytime sleepiness (EDS), and rapid eye movement sleep behavior disorder (RBD), were evaluated using the PD Sleep Scale-2 (PDSS-2), Epworth Sleepiness Scale (ESS), and RBD Screening Questionnaire (RBDSQ), respectively. Disease severity was evaluated using the Unified MSA Rating Scale (UMSARS).Results:The frequency of PD-SP (PDSS-2 score of ≥18), EDS (ESS score of ≥10), and RBD (RBDSQ score of ≥5) in patients with MSA was 18.8%, 27.3%, and 49.7%, respectively. The frequency of coexistence of all three sleep-related symptoms was 7.3%. Compared with the cerebellar subtype of MSA (MSA-C), the parkinsonism subtype of MSA (MSA-P) was associated with a higher frequency of PD-SP and EDS, but not of RBD. Binary logistic regression revealed that the MSA-P subtype, a higher total UMSARS score, and anxiety were associated with PD-SP; that male sex, a higher total UMSARS score, the MSA-P subtype, and fatigue were associated with EDS; and that male sex, a higher total UMSARS score, and autonomic onset were associated with RBD in patients with MSA. Stepwise linear regression showed that the number of sleep-related symptoms (PD-SP, EDS, and RBD), disease duration, depression, fatigue, and total Montreal Cognitive Assessment score were predictors of disease severity in patients with MSA.Conclusions:Sleep-related disorders were associated with both MSA subtypes and the severity of disease in patients with MSA, indicating that sleep disorders may reflect the distribution and degree of dopaminergic/non-dopaminergic neuron degeneration in MSA.

简介：Objective:Toexploreaneweffectiveapproachfortreatmentofthelocalirritablesymptomsandsignsresultedfrommyoporthosisoperation.Methods:263casesofradialkeratotomyoutpatientsweredividedintocontrolgroup(n=49,90eyes)andtreatmentgroup(n=214,412eyes).Patientsofcontrolgroupweretreatedwith0.5%Chloramphenicoleyedrops,3timesdaily,1-2drops/time,andwith0.5%Erythromycineeyeointmenteverynight.Intreatmentgroup,patientsweretreatedwithaoupointandhandreflectionareadigitalpressingmethodexceptwiththesameeyedropsandeyeointment.BodyacupointsusedwereCuanzhu(BL2),Yuyao(EX-HN4),Sizhukong(TE23),Sibai(ST2)andTaiyang(EX-HN5).ThehandreflexareasusedwereEyeArea,LiverArea,KidneyArea,SpleenArea,HeartAreaandLungArea.Fivedaysconstitutedatherapeuticcourse.Results:Following3courses(15days)oftreatment,themarkedlyeffectiverateandtotaleffectiverateoftreatmentgroupandcontrolgroupwere74.51%and38.89%,94.17%and66.67%respectively.Therewasasignificantdifferencebetweentwogroupsinthetotaleffectiverate(P＜0.05),showingthetherapeuticeffectoftreatmentgroupbeingbetterthanthatofcontrolgroup.Conclusion:Acupointdigitalpressingisrathereffectiveintreatmentofmyoporthosispost-operationirritablesymptomsandsigns.

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简介：AbstractGastric carcinoma is extremely rare in pregnancy and the prognosis for this malignancy tends to be dismal. We herein describe a case of gastric cancer in pregnancy to alert clinicians to this rare possibility. A 29-year-old woman developed abdominal spastic pain and diarrhea during the 26 weeks of gestation and her condition was confusing and hard to recognize. The patient was initially misdiagnosed as enterogastritis and inflammatory intestinal obstruction and was finally confirmed by exploratory laparotomy with intestinal and peritoneum metastases. Because the disease was not detected early enough and progressed rapidly, the pregnancy was terminated by cesarean section at 30 weeks of gestation, and then followed by systemic chemotherapy, but eventually succumbed to the lethal pneumonia. Therefore, it is of great significance to alert clinicians to note this rare possibility and to consider the differential diagnosis of this disease in pregnant women with a long course of gastrointestinal symptoms that cannot be explained by pregnancy alone, and cancer should be suspected and tested with sophisticated diagnostic procedures.