简介:Sonodynamictherapy(SDT)isanemergingapproachthatinvolvesacombinationoflow-intensityultrasoundandspecializedchemicalagentsknownassonosensitizers.Ultrasoundcanpenetratedeeplyintotissuesandcanbefocusedintoasmallregionofatumortoactivateasonosensitizerwhichoffersthepossibilityofnon-invasivelyeradicatingsolidtumorsinasite-directedmanner.Inthisarticle,wecriticallyreviewedthecurrentlyacceptedmechanismsofsonodynamicactionandsummarizedtheclassificationofsonosensitizers.Atthesametime,thebreathofevidencefromSDT-basedstudiessuggeststhatSDTispromisingforcancertreatment.
简介:
简介:DearEditor,IamDr.KhayWeiPohfromDepartmentofOphthalmology,HospitalKualaLumpur,Malaysia.IwritetoshareacaseofdiffusechoroidalhaemangiomainachildwithSturgerWebersyndromewhoshowedresolutionofexudativeretinal
简介:摘要BACKGROUND AND OBJECTIVESpasticity is a common sequala of the upper motor neuron lesions. For instance, it often occurs in the first 4 weeks after stroke and is seen in more than one-third of stroke survivors after 12 months. In recent years, extracorporeal shock wave therapy (ESWT) has been recognized as a safe and effective method for reducing muscle spasticity. Possible/relevant mechanisms include nitric oxide production, motor neuron excitability reduction, induction of neuromuscular transmission dysfunction, and direct effects on rheological properties. There are two types of ESWT, focused and radial, with the radial type more commonly applied for treating muscle spasticity. Concerning the optimal location for applying ESWT, the belly muscles and myotendinous junction seem to produce comparable results. The effects of ESWT on spasticity are known to last at least four to six weeks, while some studies report durations of up to 12 weeks. In this review, the authors will focus on the current evidence regarding the effectiveness of ESWT in spasticity, as well as certain technical parameters of ESWT, e.g., the intensity, frequency, location, and number of sessions. The pertinent literature has been reviewed, with an emphasis on post-stroke upper limbs, post-stroke lower limbs, cerebral palsy, and multiple sclerosis. In short, while ESWT has positive effects on parameters such as the modified Ashworth scale, mixed results have been reported regarding functional recovery. Of note, as botulinum toxin injection is one of the most popular and effective pharmacological methods for treating spasticity, studies comparing the effects of ESWT and botulinum toxin injections, and studies reporting the results of their combination, are also reviewed in this paper.
简介:联系精索静脉曲张的男不孕古典主义地用外科被管理了或帮助了繁殖技术。与在联系精索静脉曲张的不孕作为一个pathophysiological因素增加氧化应力的证据,医药治疗特别抗氧化剂可能与更低的风险成为一种治疗选择。我们在归因于精索静脉曲张的男不孕的管理在各种各样的医药代理人的角色上考察了存在文学。医药治疗典型地与外科对药治疗作为辅助治疗与安慰剂,药对手术的(b)比较,和药的(c)比较处于象二药或一药的(a)比较那样的三种不同状况被评估独自一个。由于数据的异质和进行得好的研究的缺乏,有不够的数据与联系精索静脉曲张的不孕为人推荐医药治疗的平淡的使用,外科仍然是选择的处理。怀孕和实时出生率通常没在精子参数在大多数研究和仅仅的改进被报导或抗氧化剂能力是不够的支持它的平淡的使用。抗氧化剂治疗由于它的理论利益,从现出症状之前的潜的研究的数据,和主要副作用的缺乏是一种潜在的选择。有在精索静脉曲张的外科的修理以后的抗氧化剂的辅助治疗可以改进结果并且是为进一步的研究的一个潜在的区域。
简介:Inthepresentstudy,100patientssufferingfromgastroptosiswererandomlydividedintoauricular-plastergroupandacupuncturegroup.Theeffectiveratesofthetwogroupswerebothabove90%andnostatisticallysignificantdifferenceintherateswasfoundbetweenthesegroups(P>0.05).Itindicatesthatauricular-plasterandacupuncture,thoughtheyaredifferentfromeachotherinmethodology,arebotheffectiveinthetreatmentofgastroptosis.
简介:Inthepresentpaper,theauthorsreportafewoftypicalcasesofalergicdiseasesincludingpotlinosis,asthma,redeyesandswellingfaceanddermatitistreatedwithotopointsandsomebackshu-pointsaccordingtothesymptoms.Theresultshowedthatthecurativeeffectwassatisfactory.Itindicatesthatotopointshaveagoodantlanaphylacticeffect.
简介:无
简介:Melanomaisthedeadliestformofskincancerandhasanincidencethatisrisingfasterthananyothersolidtumor.Metastaticmelanomatreatmenthasconsiderablyprogressedinthepastfiveyearswiththeintroductionoftargetedtherapy(BRAFandMEKinhibitors)andimmunecheckpointblockade(anti-CTLA4,anti-PD-1,andanti-PD-L1).However,eachtreatmentmodalityhaslimitations.Treatmentwithtargetedtherapyhasbeenassociatedwithahighresponserate,butwithshort-termresponses.Conversely,treatmentwithimmunecheckpointblockadehasalowerresponserate,butwithlongtermresponses.Targetedtherapyaffectsantitumorimmunity,andsynergymayexistwhentargetedtherapyiscombinedwithimmunotherapy.Thisarticlepresentsabriefreviewoftherationaleandevidenceforthepotentialsynergybetweentargetedtherapyandimmunecheckpointblockade.Challengesanddirectionsforfuturestudiesarealsoproposed.
简介:
简介:观察针灸的临床的效果的目的在治疗长期的湿疹与acupoint注射治疗结合了。七十个病人随机被划分成二个组的方法。在治疗组的36个盒子在针灸方面被对待,acupoint注射治疗并且与洋梅花针拍,当在控制组的34个盒子与Halometasone的Loratadine正热门申请的口头的管理被对待时,啪啪撞击。在三星期的治疗,药品和显著的有效的率和全部的有效的率以后的结果是分别地,80.6%和97.2%在治疗组织,对47.1%和79.4%在控制组织。在在二个组之间的药品和显著的有效的率和全部的有效的率的差别是统计上重要的(所有P<0.05)。没有明显的不利反应在治疗期间出现在二个组。结论针灸正acupoint注射治疗为有安全地的高度的长期的湿疹是有效的。