简介：Itiswellestablishedthatstemcellscandifferentiateintocelltypesoftheorganinwhichthesearetransplanted.However,theprocessisveryslowduetolackofunderstandingofsignalsimportantfortheirsurvivalanddifferentiation,mostoptimalstemcellsandtheirplasticity.Limitationsandadvantagesofvariouscellsubtypeswillbedescribed.Therateofstemcellsmobilizationandtheirsurvivalintheischemicenvironmentaremajorobstaclesinengraftmentanddifferentiationofstemcellsformeaningfulrepairoftheinfarctedmyocardium.Manipulationofstemcellswithischemicpreconditioning,combinedgeneandcelltherapytogetherwithsimultaneousactivationofdiversesignalingpathwaysformassivestemcellmobilization®enerationhassignificantimpactontherepairprocessbystemcells.Theseandotherdifficultiesencounteredinefficientuseofvariousstemcellshaveresultedininventionofinducedpluripotentstemcellswhichcouldrevolutionizethestemcellbasedtherapyandtheirapplicationsforunderstandingofhumandiseaseanddrugscreeninginthenearfuture.ReprogrammingofadultcellsintoiPScellswithouttheuseofviralvectorsisamajorchallengetowardsgettingiPScellswithoutviralintegrationintocells.Tomeetthischallengewehaverepro-grammedskeletalmyoblastsintoiPScellswithhighefficiencyusingepigeneticmodifiers.TransplantationofiPScellsderivedpurecardiacprogenitorsintoinfarctedmyocardiumledtoextensiverepopulationofscarareawithfullydevelopedmyocyteswithouttumorformationandresultinginmarkedimprovementincardiacfunction.Reprogrammingwithpurechemicalmeanswillmaketherapeuticuseofthesecellsmoresafer.Targetingtheinducedpluripotentstemcellstowardscardiacprogenitorsandtheirapplicationtowardstransplantationisamajorstepforwardinenhancingthemyocardialrepaircapacitybythesecells.

简介：在这份报纸，我们独自考察了雄激素剥夺治疗(ADT)的长期的幸存结果，安全，和quality-of-life对为局部地先进、变形的前列腺癌症(PCa)与放射治疗(RT)或化疗结合了。文学搜索用OvidSP被执行。满足了下列标准的使随机化的控制试用(RCT)被包括：包括局部地先进或变形的PCa，比较方法和疾病的报导量的数据控制的与任何治疗独自一个对联合的ADT或幸存结果。最后，八RCT满足了包括标准。在这些之中，三比较了ADT对ADT正RT(n=2344)并且一个人比较了ADT对ADT正docetaxel-estramustine(n=413)在局部地先进的PCa；二比较了ADT对ADT正docetaxel(n=1175)并且加estramustine的二比较ADT对ADT(n=114)在变形PCa。为局部地先进的PCa，到长期的ADT的RT的增加能与充分可接受的不利效果改进幸存和肿瘤控制的结果。特殊，分享的机会比率(或)外套，幸存(OS)是1.43(95%信心间隔1.20-1.71)什么时候独自加RT把ADT与ADT作比较(P<0.0001)。为变形神经质地敏感的PCa，加ADT的docetaxel的并发的使用有效、安全(分享或OS：1.29[1.01-1.65]：P=0.04)。总共，加docetaxel的长期的ADT正RT和长期的ADT应该分别地在局部地先进、变形的神经质地敏感的PCa被看作合适的处理选择。为纸的主要限制是仅仅八RCT是可得到的。

简介：目的：研究针灸结合中药治疗黄褐斑的效果。方法：把黄褐斑分成3型，予以针灸结合中药内服、外敷治疗。结果：针灸结合中药治疗黄褐斑有明显的效果，45例经2个疗程治疗后，有效率达93．3％。结论：针灸结合中药治疗黄褐斑有明显的效果。

简介：ＴｈｅｔｈｅｒａｐｅｕｔｉｃｐｒｉｎｃｉｐｌｅｓｏｆＡｌｚｈｅｉｍｅｒ’Ｄｉｓｅａｓｅｗｅｒｅｒｅｐｌｅｎｉｓｈｉｎｇｖｉｔａｌｅｎｅｒｇｙａｎｄｉｎｖｉｇｏｒａｔｉｎｇｂｌｏｏｄｃｉｒｃｕｌａｔｉｏｎ,ｉｎｖｉｇｏｒａｔｉｎｇｆｕｎｃｔｉｏｎｏｆｔｈｅｓｐｌｅｅｎｔｏｒｅｓｏｌｖｅｐｈｌｅｇｍ,ｓｔｒｅｎｇｔｈｅｎｉｎｇｔｈｅｍａｒｒｏｗｂｙｒｅｉｎｆｏｒｃｉｎｇｔｈｅｆｕｎｃｔｉｏｎｏｆｔｈｅｋｉｄｎｅｙ,ｉｎｖｉｇｏｒａｔｉｎｇｂｌｏｏｄｃｉｒｃｕｌａｔｉｏｎｔｏｅｌｉｍｉｎａｔｅｂｌｏｏｄｓｔａｓｉｓ.Ｔｈｅｍａｉｎｔｈｅｒａｐｅｕｔｉｃａｃｕｐｏｉｎｔｓｗｅｒｅａｓｆｏｌｌｏ

简介：AbstractOxidative stress is caused by the imbalance between the generation of free radicals/reactive oxygen species (ROS) and the antioxidant defense systems, which can activate various transcription factors and affect their transcriptional pathways. Oxidative stress plays an important role in the occurrence and development of leukemia and is closely related to the treatment and prognosis of leukemia. The standard chemotherapy strategies for the pre-treatment of leukemia have many drawbacks. Hence, the usage of antioxidants and oxidants in the treatment of leukemia is being explored and has been preliminarily applied. This article reviews the research progress of oxidative stress and leukemia. In addition, the application of antioxidants treatment in leukemia has been summarized.

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简介：Statusasthmaticusisaformofbronchialasthmaattack.Thesevereonecancausefailureofrespiratoryfunction.Toalleviatethesymptomsquickly,routinetherapycouldcombinedwithcompoundsalviamiltrorrhizainjectionandvitaminK3.Comparedthe36patientsintwogroupsandfoundtheeffectswereobvious.Intravenousdripwithcompoundsalviamihiorrhizainjectioncandilatethevessel,improvethemicrocirculationandpulmonarycirculation,correctoxygendeficitandquickelydispelsputum,thusit'sconductivetotheeliminationofconvulsionofairway.VitaminK3canpromotethesynthesisandconversionofcyclicAMPandalleviatetheinflammatoryexudation,thusimproveandstrengthenthefunctionofventiliation.

简介：Glioblastoma(GBM)isatypeoftumorthatishighlylethaldespitemaximaltherapy.Standardtherapeuticapproachesprovidemodestimprovementinprogression-freeandoverallsurvival,necessitatingtheinvestigationofnoveltherapies.Oncologictherapyhasrecentlyexperiencedarapidevolutiontoward'targetedtherapy',withdrugsdirectedagainstspecifictargetswhichplayessentialrolesintheproliferation,survival,andinvasivenessofGBMcells,includingnumerousmoleculesinvolvedinsignaltransductionpathways.Inhibitorsofthesemoleculeshavealreadyenteredorareundergoingclinicaltrials.However,significantchallengesintheirdevelopmentremainbecauseseveralpreclinicalandclinicalstudiespresentconflictingresults.Inthisarticle,wewillprovideanup-to-datereviewofthecurrenttargetedtherapiesinGBM.

简介：AcupunctureTreatmentfor54DisorderswaswrittenbyHuangQinfengandQiLizhen,andpublishedbyShanghaiScientific&TechnicalPublishersin2002.Thebookcollected54commondisordersinclinicfromabout5451articlespublishedinhundredsjournalsbetween1980and

简介：ObjectiveTostudytheroleofdiureticagentsintreatingsuddendeafness(SD)andexplorethepossibilityofendolymphatichydropsasapotentialcauseofSD.MethodsTwenty-eightSDcaseswerereviewed.In23cases,treatmentwasinitiatedwithroutineagents.Diureticagentswerelateraddedin8ofthesecasesthatfailedtorespondtoroutinetreatmentagents.Diureticagentswereincludedintheinitialtreatmentintherest5cases.Intotal,13casesreceiveddiureticsinadditiontoroutinetreatmentagentsand15casesreceivedconventionaltreatmentonly.ResultsInthe8caseswhoreceiveddiureticsafterfailedconventionaltreatments,4showedhearingimprovement,whereasall5casesinwhichdiureticswereincludedintheinitialtreatmentdemonstratedhearingimprovement.ConclusionTheseresultssuggestapossibleroleofendolymphatichydropsinthepathophysiologiccourseofSD.Diureticsshouldbeconsideredwhenclearindicationsexistwithnoconflictstoothermedicalconditions.

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简介：Objective:Toexploretheinjurymechanismandtreatmentprincipleofopensupracondylarfractureofhumerus.Methods:Thedataof32patientswithopensupracondylarfractureofhumerushospitalizedinourdepartmentintherecent20yearswereanalyzedretrospectively.Onanaverage,theywerefollowedupfor30months.Therelationshipbetweenthefracturetype,situationofwounds,operatingtime,operatingmethodandtimeforpostoperativefunctionalexerciseandfinalfunctionofelbowjointwereevaluatedwithFlynnscoringstandard.Results:Excellenttherapeuticeffectwasfoundin14cases,goodin12andbadin6,withthepercentageoffinetherapeuticeffectof81.25%.Conclusions:Forthepatientswithopensupracondylarfractureofhumerus,debridementandinternalfixationshouldbemadeasearlyaspossible,forthoroughdebridementandcorrectinternalfixationarethekeypointstoimprovetheprognosis.

简介：Retinoblastoma(RB)isthemostcommonintraocularcancerofinfancyandchildhood.ThiscancerisinitiatedbymutationonRB1,thetumorsuppressorgenethatisresponsiblefortheregulationofbothcellcycleandgnomestabilityinretinalcells.PatientswithaconstitutionalmutationonRB1canbeinherited.RBoccursapproximately1inevery15000-20000livebirths.Theworldwidemortalityforthiscancerisabout5%-11%.However,thisraterisestoabout40%-70%indevelopingcountriesduetoadelayindiagnosis.Awidevarietyofoptionsareavailableforthetreatment,butoftenacombinationoftherapiesisadoptedtooptimizeindividualizedcare.

简介：破坏损害被定义为avery骨头和软纸巾的严重损坏。我们在一些破裂盒子中发现了那的Butin临床的实践，软纸巾的损坏不象“destructiveinjury”一样严重显示，而弄碎破裂stillcannot表演骨头损坏的严厉。因此我们proposeda新术语“destructivefractures”在把破坏损害的定义与典型诊所盒子相结合以后。破坏破裂指谁的破裂骨状的纸巾太严重被损坏被修理，但是软纸巾，神经和静脉是严重地伤害的更少，canbe修理。从一年2001～2010，破坏破裂的75个盒子被同意进入我们的部门。根据是否与外部环境连结的破裂和破裂地点，他们被划分成6种类型：al类型，关上的骨干破坏骨折；a2类型，开的骨干破坏骨折；bl类型，关上的包含关节的破坏骨折；b2类型，开的包含关节的destructivefracture；c1类型，关上的混合破坏骨折；c2类型，开的混合破坏骨折。相应临床的治疗为破坏骨折的新分类标准是的每type.The被进行简单、实际并且thuscan被用作一个重要指南为破坏破裂做合理treatmentplans。

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简介：Inthepresentpaper,theauthorreportstheresultsofacupunctureofHouding(GV19)andotheracupointsselectedalongthemeridianfortreatingsciatica.Atotalof92sciaticapatientswererandomlydividedintoHoudinggroup(n=62)andcontrolgroup(n=30).InHoudinggroup,patientsweretreatedmainlywithpuncturingHouding(GV19),combinedwithHuantiao(GB30)whennecessary.Incontrolgroup,patientsweretreatedwithHuantiao(GB30),Yanglingquan(GB34)orZhibian(BL54),Weizhong(BL40),Chengshan(BL57),Kunlun(BL60),etc.whichwereselectedalongtherouteofmeridian.Resultsindicatedthatfollowing10sessionsoftreatment,inHouingandcontrolgroups,ofthe62and30cases,44and15werebasicallycured,18and10wereimproved,0and5failedinthetreatment,withthetotaleffectiveratesbeing100%and83,3%respectively.ThetherapeuticeffectofHouding(GV19)issignificantlysuperiortothatofacupointsselectedalongthemeridian.

简介：<正>Thefacialnervepassesthroughthetemporalboneandisthelongestnervethattravelsinabonycanalwithacomplexcourseandhighsusceptibilitytoinjury.Whenfacialnervebecomesswollenfrominsultssuchastrauma,inflammation,tumororiatrogenicinjury,itsdistal

简介：分析了符合统计要求的62篇关于肥胖的论文，发现常用治疗方法有针刺、针灸、电针、耳穴贴压、耳针、(耳穴)埋针、穴位敷贴、穴位埋藏及针灸配合其他疗法等；常用耳穴为胃、内分泌、神门、肺、脾、饥点和三焦，临床总有效率为75．8％。

简介：ＤＩＡＧＮＯＳＩＳＡＮＤＴＲＥＡＴＭＥＮＴＯＦＭＵＬＴＩＰＬＥＰＲＩＭＡＲＹＣＡＲＣＩＮＯＭＡＳＺｈａｎｇＳｈｕａｎｇｍｉｎ张双民ＭａＳｏｎｇｚｈａｎｇ马颂章ＹａｎｇＤａｌａｉ杨大来ＣｈｅｎＳｈｕｇｕａｎｇ陈曙光ＹａｎｇＣｈｕｎｍｉｎｇ杨春明Ｓｏｎ...