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简介:目的探讨经桡动脉冠脉介入诊疗的可行性及安全性。方法选择符合冠脉造影指征并Allen’s试验阳性患者150例,以右桡动脉途径行冠脉造影,对符合介入指征者行介入治疗。结果造影成功142例,成功率94.7%,失败8例,其中7例为穿刺不成功(桡动脉痉挛5例,桡动脉斑块狭窄1例,急诊患者血压低1例),1例因造影管打折不能松解经动脉切开术取管后改股动脉途径。造影成功者中对50例患者行介入治疗,经桡动脉途径48例成功置入支架73枚,成功率96%,失败2例均因痉挛指引导管无法到位。造影及介入治疗不成功者改股动脉途径均获成功。术后6例发生手臂肿胀,12例出现伤口局部水泡,无桡动脉闭塞,出血,血肿,夹层等发生。结论经桡动脉行冠脉介入诊疗安全可行,创伤小,并发症小,病人易于接受,值得推广。
简介:BackgroundTheremaybedysregulationofcirculatingmicroRNAsinacutemyocardialinfarction(AMI),whichisanaging-relatedprocess.However,thedifferencebetweenyoungandelderlypeopleinexpressionlevelofcirculatingmiR-21inAMIpatientshasnotbeeninvestigated.MethodsThestudyincluded72consecutivepatientswithAMI.ThegroupIconsistedof43patientsagedequaltoorabove65yearsandthegroupIIconsistedof29patientsagedequaltoorbelow45years.Real-timeRT-PCRwasappliedtodetectserummiR-21expressionlevelsatthetimeofmechanicalreperfusionand12h,D1,D3andD7afterPCI,respectively.ResultsTheexpressionlevelofmiR-21inAMIpatientsincreasedmarkedly12hafterPCIandreachedthepeakatD1afterPCIinbothgroups.TherewasnodifferenceofmiR-21expressionbetweenGroupⅠandⅡatthetimeofmechanicalreperfusion(5.12±0.73vs.4.98±0.87)andD7afterPCI(1.28±0.75vs.1.94±0.89),However,groupⅠpatientsexhibitedhighermiR-21expressionlevelthangroupⅡat12h(7.96±0.78vs.4.23±0.77,P<0.05),D1(9.32±0.89vs.6.12±0.92,P<0.05)andD3(4.78±0.91vs.2.97±0.77,P<0.05)afterPCI,respectively.ConclusionOurdatarevealanincreaseofmiR-21inpatientswithAMImaybeamechanismofmyocardialischemiareperfusioninjury.TheexpressionofmiR-21wasrelatedtothedevelopmentandprogressionofAMI,andthereisanage-relatedchangeintheexpressionofmiR-21inacutemyocardialinfarctionpatients.