简介：目的：通过检测高度近视性弱视者弱视眼黄斑区视网膜神经节细胞厚度,探讨该类弱视的程度与视网膜神经节细胞厚度的关系。方法：选取先天性高度近视（10g/L阿托品眼膏散瞳后〉-4.00DS）并伴有弱视患者12例20眼。年龄3.5～15岁。采用傅立叶域光学相干断层扫描仪（fourier-domainopticalcoherencetomography,FD-OCT）测量弱视眼的黄斑区神经节细胞厚度以及黄斑区视网膜厚度,并比较神经节细胞层厚度占视网膜层厚度的比例与患者弱视及近视程度的相关性。结果：我们发现高度近视患者近视程度与最佳矫正视力无明显相关性,近视程度高的患者其神经节细胞层相对厚度有变薄现象。结论：先天性近视性弱视的患者黄斑中心区神经节细胞层厚度占视网膜厚度的比例有下降。

简介：1适应对象在选择患者作为耳蜗植入器的手术对象时,一般要进行以下逐个项目的询问或检查.1.1邮询筛选许多患者通过来信要求治疗,可借此机会复函,请患者回答以下问题,从中初选有可能的对象,函询内容如：耳聋程度;助听器效果;耳聋起病年龄及可能原因;旁人能听懂本人讲话的程度;患者结合唇形读懂话的能力（包括家属和本人的讲话）;耳流脓或耳手术史;全身健康状况以及经济情况和来院诊治的条件等.

简介：AIM:Toexaminethemechanismofthedevelopmentofpseudoexfoliation(PSX)syndromeviabothcytokineformationandendothelialvasorelaxingandgrowthfactorsthatwillprovideusnewtherapeuticinsightsforthetreatment.METHODS:Thisisacrosssectionalstudyincludedtwogroups;Group1:controlpatientswithnuclearcataract(n=20,aged51-80years).Group2:PSXpatientswithnuclearcataract(n=18,aged50-90years).Patientswithotherophthalmicproblemsandsystemicdiseaseswereexcluded.Vascularendothelialgrowthfactor(VEGF),interleukin-6(IL-6)andinterleukin-1β(IL-1β)andnitrotyrosinelevelsweredeterminedthroughserumsamplesbyEnzyme-linkedimmunosorbentassay(ELISA)method.Nitrite-nitratelevelsweremeasuredwithphotometricendpointdetermination.RESULTS:Therewerenosignificantdifferencesbetweenthegroupsintermsofage,VEGF,IL-1β,nitrite-nitrateandnitrotyrosine.ThesignificantresultswerethemeanIL-6levelsthatwerehigherinPSXgroup2(37.68±29.52pg/mL)comparedtothatincontrolgroup1(15.32±10.08pg/mL)(P<0.001).CONCLUSION:SeveralinteractingandextendingbiochemicalpathwaysmayleadtothepromotionofVEGFandIL-6expressions.IL-6whichistheonlyalteredmarkerinourstudymayindirectlycauseanincreaseofvascularpermeabilityandneovascularization.WesuggestinflammationasafactorthatcanbeinvolvedinetiopathogenesisofPSX.

简介：·AIM:Tostudytheeffectsofdanhonghuayukoufuye(DHK)onfastingbloodglucose(FBG)anddiabeticretinopathy(DR)instreptozotocin(STZ)-inducedtype1diabeticratstofacilitatetherationalusageofthisdrug.·METHODS:DiabeticratswereinducedbyinjectionofasingledoseofSTZintraperitoneallyat50mg/kg.Flashelectroretinogram(FERG)andoscillatorypotentials(OPs)wereusedtomeasureretinalfunction.Themicrovascularperfusionofearswasperformedtostudythemicrocirculationinrats.FBG,body-weight,and24-hurinevolume,waterintakeanddietintakewerealsoassessed.·RESULTS:DHKhadnoeffectonFBGinnormalrats.However,STZ+DHKgroupweresignificantlydifferentfromthoseofModelandmovedtowardthoseofnormalcontrol.Itreversedtheincreaseindietintake(P≤0.05vsmodelcontrol)andthelossinbody-weight(P≤0.05vsmodelcontrol)indiabeticrats.DHKdecreasedtheFBGofdiabeticratsby25.6%(P≤0.05)and37.9%(P≤0.01)after14and21daysadministrationascomparedwiththemodelcontrol,respectively.Moreover,DHKsignificantlyincreasedtheFERGb-waveamplitudeby80%(P≤0.05vsmodelcontrol)anddecreasedtheFERGb-wavelatencyby15.3%(P≤0.01vsmodelcontrol)after24daysadministration.TheOP1andOP2amplitudesinDHKgroupwere2.6(P≤0.01)and2.0(P≤0.01)timesofmodelgroupafter24daysofDHKtreatment,respectively.Atthesametime,OP1andOP2latenciesinDHKgroupreducedby16.0%(P≤0.001)and14.7%(P≤0.001)ascomparedwiththemodelcontrol,respectively.Furthermore,themicrovascularperfusionofDHKgroupwas2.4timesofmodelgroup(P≤0.001)after21daysadministration.·CONCLUSION:DHKhadnoeffectonnormalFBG.Butithadantihyperglycemicactivity,andhadapreventiveandtherapeuticeffectonDRindiabeticrats.·

简介：AIM:Toanalyzetheapplicationofmicrobubblecontrasttechnologyinthetreatmentofophthalmicdiseases,mainlyanalyzingitsadvantagesandexistingproblems.METHODS:Atotalof30representativeliteraturesabouttheapplicationofultrasoundcontrastagentingenetargetedtherapyathomeandabroadwerecollected,andfocusingonsortingouttheliteraturereportingthetreatmentofophthalmicdiseaseswithmicrobubblecontrasttechnologyinrecentyears,thenrecallingitsadvantagesandproblems,finallymakingreasonableassessmentonexistingproblemsandproposingpossiblesolutionstotheproblems.RESULTS:Duetoitsuniquesafetyandefficacy,thetreatmentofophthalmicdiseaseswithmicrobubblecontrasttechnologyhasincreasinglydrawntheattentionofclinicians,buttworelevantissuesshouldbeconsidered:first,thenatureofcontrastagentandthechoiceofcorrespondingultrasoundparameters;second,relativeincidenceoftissuebleeding,intravascularhemolysis,moderateorsevereallergyaswellasothersideeffects.CONCLUSION:Microbubblemaybecomethecarrieroftargetedtherapy,andasakindofnewnon-invasivedeliverysystem,theultrasoundcontrastagenthasbroadapplicationprospects,butitsapplicationinophthalmicresearchisstillinitsinitialstageandthesafetyofcontrast-enhancedultrasoundstillneedsfurtherstudy.

简介：AIM:TotrainTibetanmonkey(Macacathibetana)forintraocularpressure(IOP)measurementinconsciousstateandobtainnormalIOPinconsciousTibetanMacaque.·METHODS:Thetrainingwasbasedonaward-conditionedbehavior.Foodstimulationandhuman-animalinteractionwereusedinthistraining.·RESULTS:TrainedTibetanmonkeyscalmlyacceptedIOPmeasurementbytheTonoVet?誖reboundtonometerwithoutsedationoranesthesiaandtheirIOPvaluesweresimilartootherprimates.·CONCLUSION:Human-cultivatedThibetanmonkeysaretamable,andcanbeusedforbiomedicalresearchsuchasophthalmicresearchwithoutanesthesia.

简介：AIM:ToanalyzecasesofobstructionofthenasolacrimalductwhichcreatesafertileenvironmentforsecondarybacterialInfectionandcanresultindacryocystitis,whichisaconstantthreattocorneaandorbitalsofttissueandapotentialsourceofendophthalmitisfollowingintraocularsurgery.Themajorityofobstructionsofthelacrimalexcretoryoutflowsystemareacquiredonesoccurringinadulthoodandinvolvingthedistalpartsofthesystem.Acquiredobstructionmaybeprimary/idiopathicorsecondarytoawidevarietyofinfectious,inflammatory,traumatic,mechanical,toxicorneoplasticcausesmimickingidiopathicinflammation.Thesecasesaretreatedbydacryocystorhinostomy(DCR).METHODS:Thepresentstudywasconductedtodeterminethehistopathologic,immunohistochemicalandcurrentmicrobiologiccharacteristicsoflacrimalsacspecimensinpatientsundergoingexternaldacryocystorhinostomy.RESULTS:Non-specificlacrimalsacpathologywaspresentinall33casesand81.8%ofthecasesshowedmoderatechronicinflammationwithachronicinflammatoryscore(CIS)rangingbetween4and6,whereas12.12%showedsevereinflammatorychangeswithaCISof7.Milddegreeofinflammationwasseenin6.06%withaCISof3.Thetotalprevalenceofgrampositive,gram-negative,andculture-negativesampleswere59.4%,37.5%,and3%respectively.CONCLUSION:Non-specificchronicinflammationwithfibrosisisindeedthemostcommonlyreportedhistopathologicalfindinginlacrimalsacwallbiopsyspecimens.

简介：AIM:Toexaminetheexpressionofsurvivinandvascularendothelialgrowthfactor(VEGF)duringthedevelopmentofretinalneovascularization(NV)inamousemodel.·METHODS:Awell-characterizedmurinemodelofretinalNVwasusedtostudytheexpressionofsurvivinandVEGF.NVoftheretinawasinducedinmicebyexposureto75%O2frompostnataldayP7toP12,followedbyreturntoroomairfromP12toP17.ExpressionofsurvivinandVEGFproteinwasanalyzedbyImmunohistochemistry.Inaddition,mousemodelofproliferativeretinopathywasanalyzedbyretinalfluoresceinangiographyandquantificationanalysis.·RESULTS:Thenormalmicehadbothsuperfiekalanddeepvascularlayersthatextendedfromtheopticnervetotheperiphery.Inintraocularpressure(IOP)micewerecharacterizedbyrepresentatypicalpatternofpathologicalretinalNV.Therearelessorlittlenucleiofnewvesselsvascularendothelialcellbreakingthroughtheinnerretinalthaninretinopathyofprematurity(ROP)mice,largeclustersofbloodvesselswereadherenttotheinternallimitingmembrane(ILM)(0.27±0.20vs23.38±1.027,t=9.454,P<0.001).DuringtheangiogenicperiodfromP13toP17,survivinandVEGFproteinexpressionincreasedinexperimentalretinascomparedwithcontrolsamples(2.56±0.46vs3.34±0.40,t=17.43,P<0.01:2.18±0.75vs4.34±0.25,t=19.61,P<0.01).ProteinlevelsofVEGFandsurvivnhassignificantlypositivecorrelation(P<0.05,r=0.411).·CONCLUSION:CorrelationwasmadeattheproteinlevelsofsurvivinexpressioncomparedwiththatofVEGFinamurinemodelofretinalNV,whichsuggestsatemporalroleforsurvivinandVEGFinnewvesselformationinresponsetohypoxicstimulation.

简介：AIM:ToinvestigatetheeffectofintravitrealinjectionofDL-alpha-aminoadipicacid(DL-α-AAA)onocularrefractivestateandretinaldopamine,transforminggrowthfactor-β2(TGFβ2),vasoactiveintestinalpolypeptide(VIP)inguineapigform-deprivedmyopia.METHODS:Four-week-oldpigmentedguineapigswererandomlyassignedto4groups:normalcontrol,deprivation,deprivationplusDL-α-AAA,deprivationplussaline.Formdeprivationwasinducedwiththeself-madetranslucenteyeshields,andlastedfor14days.8μgDL-α-AAAwasinjectedintothevitreouschamberofdeprivedeyes.Thecornealradiusofcurvature,refractionandaxiallengthweremeasured.Retinaldopaminecontentwasevaluatedbythehigh-performanceliquidchromatographywithelectrochemicaldetection,andTGFβ2andVIPproteinweredetectedbyWesternblotting.RESULTS:Fourteendaysofeyeocclusioncausedtheaxiallengthtoelongateandbecomemyopicintheform-deprivedeyes,withthedecreaseofretinaldopamineandtheincreaseofTGFβ2andvasoactiveintestinalpolypeptide(VIP)protein.IntravitrealinjectionofDL-α-AAAcouldinhibitthemyopicshiftfrom(-3.65±1.06)Dto(-1.48±0.63)D,P<0.01duetogogglesoccludingandcausethedecreaseofretinalTGFβ2proteininthedeprivedeyes.However,intravitrealinjectionofDL-α-AAAhadnosignificanteffectonretinaldopamineandVIPproteinindeprivedeyes.RetinalTGFβ2proteincorrelatedhighlywiththeocularrefraction(y=-3.34+0.31/x,F=74.75,P<0.001)andaxiallength(y=8.39-0.02/x,F=48.32,P<0.001)indifferenttreatmentgroups.·CONCLUSION:IntravitrealinjectionofDL-α-AAAiseffectivelyabletosuppressthedevelopmentofformdeprivationmyopia,whichmaybeassociatedwithretinalTGFβ2proteininguineapigs.

简介：AIM:Tostudythedistributionofocularhigher-orderaberrations(HOAs)andmesopicpupilsizeinindividualsscreenedforrefractivesurgery.·METHODS:OcularHOAsandmesopicpupilsizewerestudiedin2458eyesof1240patientswithmyopia,myopicastigmatismandcompoundmyopicastigmatismand215eyesof110patientswithhyperopia,hyperopicastigmatismandcompoundhyperopicastigmatismusingtheZywaveaberrometer(Busch&Lomb).Allpatientshadcorrectablerefractiveerrorswithoutahistoryofrefractivesurgeryorunderlyingdiseases.Root-mean-squarevaluesofHOAs,totalsphericalaberration,totalcomaandmesopicpupilsizewereanalyzed.OcularHOAsweremeasuredacrossa≥6.0mmpupil,andpupilsizemeasurementswereperformedunderthemesopiccondition.·RESULTS:ThemeanvaluesofHOAs,totalsphericalaberrationandtotalcomainthemyopicgroupwere0.369μm,±0.233,0.133±0.112μmand0.330±0.188μm,respectively.InthehyperopicgroupthemeanvaluesofHOAs,totalsphericalaberrationandtotalcomawere0.418μm±0.214,0.202±0.209μmand0.343±0.201μm,respectively.HyperopesshowedgreatertotalHOAs(P<0.01)andtotalsphericalaberration(P<0.01)comparedtomyopes.Inage-matchedanalysis,onlytheamountoftotalsphericalaberrationwashigherinthehyperopicgroup(P=0.05).Mesopicpupilsizeinthemyopicgroupwaslarger(P≤0.05).·CONCLUSION:TheresultssuggestedthatsignificantlevelsofHOAswerefoundinbothgroupswhichareimportantforplanningrefractivesurgeriesonIranians.Thereweresignificantlyhigherlevelsoftotalsphericalaberrationinhyperopescomparedtomyopes.Mesopicpupilsizewaslargerinmyopicgroup.

简介：AIM:Toevaluatetheeffectsandsafetyofphacoemu-lsification(Phaco)orsmall-incisionextracapsularcataractsurgery(SICS)andintraocularlens(IOL)implantationforagedpatients.METHODS:Totally137agedpatients(149eyes)underwentcataractoperationinthecaseofstablesystemiccondition,thebloodpressurelessthan160/95mmHg,bloodglucoselessthan8mmol/L,andunderthehelpofelectrocardiogramsurveillancebyanesthesiologistsduringtheoperation.106agedpatients(114eyes)underwentPhacowhile31agedpatients(35eyes)underwentSICS.Thepostoperativevisualacuity,cornealendothelialcellloss,surgerytimeandmajorcomplicationswereobservedandanalyzedretrospectively.RESULTS:Thebest-correctedvisualacuity(BCVA)of≥0.6wasachievedin135eyes(92.6%)at1monthpostoperatively(χ2=259.730,P<0.001).Foragedpatients,bothPhacoandSICScouldsignificantlyimprovevisualacuitywithnosignificantdifference(χ2=4.535,P>0.05).Postoperativecornealendothelialcelllosswas18.6%,inPHACOgroup,theratewas18.5%;inSICSgroup,theratewas19.0%,thedifferenceofwhichwasnosignificant(χ2=0.102,P>0.05).Thesurgerytimewasdifferentintwogroups.Noseverecomplicationsoccurred.CONCLUSION:BothPhacoandSICScombinedwithIOLimplantationforagedpatientsareeffectiveandsafe.Beforesurgery,detailedphysicalexaminationshouldbeperformed.Whenthesystemicconditionisstable,cataractsurgeryforagedpatientsissafe.

简介：AIM:Toexaminetheα-Galgeneexpressionanddistributioninthedifferentspecies/genusanddevelopingphaseanimalocularsurfacetissue.METHODS:α-Galbindingassaywerecarriedoutonvariousanimaleyesections.Photograph,slit-lampobservationonvariouseyeshowednormalcornealtransparence.RESULTS:Astrongα-Galexpressionininvertebratesandsomevertebratesoculartissue,butnoα-Galbindinginbirds,fishandmammal.α-Galexpressionchangeinthedevelopmentofmiceocularsurfacetissue(exceptsclera)anddisplaygenusdependencyinthedifferentmurineocularsurfacetissue.CONCLUSION:Thisstudyidentifiedspecificα-Galepitopesbindingareaintheocularsurfaceofseveralspeciesandmaysolvetheproblemthatnaiveocularsurfacemaybeusedasnaturalα-Galgeneknockoutmodel/highriskimmunologicrejectionmodelorocularsurfacescaffoldmaterial.

简介：AIM:ToinvestigatetheexpressionsoftypeIcollagen,α2integrinandβ1integrinintheposteriorscleraofguineapigswithdefocusmyopiaandwhetherbasicfibroblastgrowthfactor(bFGF)injectioninhibitstheformationanddevelopmentofmyopiabyupregulatingtheexpressionoftypeIcollagen,α2integrinandβ1integrin.METHODS:After14daysoftreatment,therefractivestateandaxiallengthweremeasuredandthelevelsoftypeIcollagen,α2integrinandβ1integrinwereassayedintheposteriorscleraeofgroupsofguineapigsthatworeamonocular-7Dpolymethylmethacrylate(PMMA)lensorhad-7DlenswearfollowedbytheperibulbarinjectionofPhosphateBufferSolution(PBS)orbFGF.Theuntreatedfelloweyeservedasacontrol.Guineapigswithnotreatmentservedasnormalgroup.·RESULTS:Theresultsshowedthat14daysofmonoculardefocusincreasedaxialeyelengthandrefraction,whilebFGFdeliveryinhibitedthemmarkedly.Further,itwasalsofoundthatthemonocular-7DlenscoulddecreasethelevelsoftypeIcollagen,α2integrinandβ1integrinexpressions,while,unlikePBS,bFGFincreasedthemsignificantlyincomparisontocontralateralcontroleyesandnormaleyes.CONCLUSION:bFGFcanpreventtheformationanddevelopmentofdefocusmyopiabyupregulatingtheexpressionsoftypeIcollagen,α2integrinandβ1integrin.Takentogether,ourresultsdemonstratethatbFGFpromotesscleraremodelingtopreventmyopiainguineapigs.

简介：AIM:Toassesstheeffectivenessofimmunosuppressantsintheprophylaxisofcornealallograftrejectionafterhigh-riskkeratoplastyandnormal-riskkeratoplasty.METHODS:WesearchedtheCochraneCentralRegisterofControlledTrials(CENTRAL),MEDLINE,EMBASE,CNKI,VIPandreferencelistsofarticles.Dateofmostrecentsearch:18June,2011.Allrandomisedcontrolledtrials(RCTs)assessingtheuseofimmunosupressantsinthepreventionofgraftrejection,irrespectiveofpublicationlanguage.Twoauthorsassessedtrialqualityandextracteddataindependently.Onlydichotomousoutcomes(cleargraftsurvival,ratioofimmunereactionsandsideeffects)wereavailableandwereexpressedasrelativerisk(RR)and95%confidenceintervals(CI).RESULTS:Sevenstudieswereincludedinthisreview.Inthecomparingofmycophenolatemofetil(MMF)withplacebo,theresultsshowedMMFcouldsignificantlyreduceimmunereactionscomparedwithplacebo(RR1.0895%Cl0.95to1.21),butnoeffectoncleargraftsurvival(RR1.1195%Cl0.90to1.35).Incleargraftsurvivalandimmunereactions,MMFandcyclosporineA(CsA)showedsimilareffect(RR1.1195%Cl0.90to1.35,andRR1.48,95%Cl0.56to3.93,respectively).Tacrolimus(FK506)andsteroidshowedsimilareffectsoncleargraftsurvivalandimmunereactions(RR0.32,95%CI0.02to6.21,andRR1.00,95%CI0.88to1.14,respectively).Nodrugrelativesideeffecthasbeenfound.CONCLUSION:MMFmayreduceimmunereactionsinbothnormal-riskandhigh-riskrejectionofpenetratingkeratoplasty.CsAandFK506showedsimilareffectsasMMF.However,duetothelackoflargeclinicaltrials,theevidenceremainweak,thequalityofevidenceswereratedasverylowtomoderate.Large,properlyrandomised,placebo-controlled,doublemaskedtrialsareneededtoevaluatetheeffectofimmunosuppressants.

简介：·AIM:Toreportvariousocularinjuriescausedbydurianfruit.·METHODS:Threecasesofocularinjuriesweredescribedinyoungpatients,duetoaccidentalfallofdurianfruitontheforeheadandface,whiletheyweretakingrest/sleeping/playingundertheduriantree.·RESULTS:Theocularinjuriesobservedwerelaceratinginjuryofcorneawithirisincarceration,hyphema,superficialpenetratinginjuryofscleraandanglerecessionglaucomaintherighteyeoffirstpatient;laceratinginjuryofcorneawithirisprolapseinthelefteyeofsecondpatient;subconjunctivalhaemorrhage,traumaticmydriasisandsuperficialpenetratinginjuryofsclera,commotionretinopathyandmacularedemainthelefteyeofthirdpatient.Visionimprovedtonormalinalltheeyesfollowingsurgical/medical/opticaltreatment.·CONCLUSION:Evidenceofpenetratinginjury(becauseofthorns)andbluntinjury(becauseofweight)canbeseenintheeyeswhendurianfruitfallsontheface.Visioncanberecoveredfullywithimmediateandappropriatetreatmentinthesecases.Theocularinjuriescanbepreventedbyeducatingthepublictowearprotectivemetalframewidegogglesandnottosleep/takerestundertheduriantree.

简介：Oculardrugtransportbarriersposeachallengefordrugdeliverycomprisingtheocularsurfaceepithelium,thetearfilmandinternalbarriersoftheblood-aqueousandblood-retinabarriers.Oculardrugdeliveryefficiencydependsonthebarriersandtheclearancefromthechoroidal,conjunctivalvesselsandlymphatic.Traditionaldrugadministrationreducestheclinicalefficacyespeciallyforpoorwatersolublemoleculesandfortheposteriorsegmentoftheeye.Nanoparticles(NPs)havebeendesignedtoovercomethebarriers,increasethedrugpenetrationatthetargetsiteandprolongthedruglevelsbyfewinternalsofdrugadministrationsinlowerdoseswithoutanytoxicitycomparedtotheconventionaleyedrops.Withtheaidofhighspecificityandmultifunctionality,DNANPscanberesultedinhighertransfectionefficiencyforgenetherapy.NPscouldtargetatcornea,retinaandchoroidbysurficialapplicationsandintravitrealinjection.ThisreviewisconcernedwithrecentfindingsandapplicationsofNPsdrugdeliverysystemsforthetreatmentofdifferenteyediseases.

简介：AIM:Toreportthelong-termvision-threateningcomplicationsinpatientswhounderwentphakicintraocularlens(pIOLs)implantationforhighmyopia.METHODS:Thisstudywasdesignedfromaconsecutiveseriesofphakicintraocularlenscomplicationandcorrectivesurgeries.Sixteeneyesof13patientshadimplantationofphakicintraocularlensforcorrectionhighmyopiaanddevelopedseriouscomplicationshavebeenincludedinthisstudy.Themeanageofpatientswas38.6±6.35y(range32-50y)andthemeantimeofhistoryofpIOLimplantationforhighmyopiawas6±2y(range2-10y).Beforecorrectivesurgery,bestspectaclecorrectivevisualacuity(BSCVA)rangedfromperceptionto20/200intheeyesinwhichseverecomplicationsoccurred.RESULTS:Cornealdecompensationoccurredin12eyesof9highmyopicpatientsafteranteriorchamberpIOLimplantation.Rhegmatogenousretinaldetachment(RRD)occurredin4eyesof4highmyopicpatientsfollowinganteriorchamberandposteriorchamberpIOLimplantation.Patientswithcornealdecompensation,hadcombinedproceduresconsistingofpIOLremovalandpenetratingkeratoplasty(PKP).RemovalsofpIOL,phacoemulsificationandparsplanavitrectomy(PPV)withsiliconeoiltamponadewereperformedinpatientswithRRD.Aftercorrectivesurgeries,allpatientsbutone(P+,patient2,righteye)achievedmoderateBSCVArangedfrom20/200to20/50atthelastvisit.CONCLUSION:PhakicIOLsmaybeeffectiveforthecorrectionofhighmyopia.AlthoughtheseIOLsmayhaveseverecomplicationsanditaffectssafetyandefficacyofthissurgery.Asseenhere,cornealdecompensationandrhegmatogenousretinaldetachmentarepossiblepostoperativevision-threateningcomplicationsofphakicIOLs.Patientsmustbecarefullyexaminedbeforeandaftersurgeryforpossibleendothelialcelllossandvitreoretinalproblems.

简介：AIM:Toassesstheawarenessofeyecomplicationsandtheprevalenceofretinopathy,inthefirstvisittoeyeclinic,amongtype2diabeticpatientsattendingatertiarymedicalcentreinKualaLumpur,Malaysia.METHODS:Aninvestigator-administeredquestionnairewasgivento137patientswithdiabetesundergoingfirsttimeeyescreeningintheeyeclinic.Thiswasfollowedbyadetailedfundusexaminationbyaseniorophthalmologisttoassessforpresenceofretinopathy.RESULTS:Almost86%ofrespondentswereawareofdiabeticeyecomplications,especiallyinpatientswhohadachievedtertiaryeducationallevel(96.3%).Themajorityofthepatients(78.8%)werereferredbytheirphysiciansandonly20.4%cameontheirowninitiative.Manyofthepatients(43.8%)didnotknowhowfrequenttheyshouldgoforaneyecheck-upand72.3%didnotknowwhattreatmentswereavailable.Lackofunderstandingondiabeticeyediseases(68.6%)wasthemainbarrierformostpatientsfornotcomingforeyescreeningearlier.Despiteahighlevelofawareness,only21.9%hadrecordedHbA1clevelof<6.5%while31.4%wereundertheerroneousassumptionofhavingagoodbloodsugarcontrol.Atotalof29.2%haddiabeticretinopathyintheirfirstvisiteyetesting.CONCLUSION:Inthepresentstudy,29.2%oftype2diabeticpatientshadretinopathyintheirfirsttimeeyetesting.Althoughtheawarenessofdiabeticeyecomplicationswashighamongfirsttimeeyescreeningpatients,theappropriateeyecare-seekingbehaviorwascomparativelylessandshouldberectifiedtopreventtheriseofthissightthreateningeyedisease.

简介：视网膜有髓神经纤维合并高度近视参差性弱视是以视网膜有髓神经纤维合并患高度近视、屈光参差性弱视为主要特征的一组综合征,多发于单眼,可严重威胁患者的视力和视功能.目前其原因不详,症状的进展规律尚不明确,治疗效果和预后各异.近年来随着眼科诊疗技术的进步,对视网膜有髓神经纤维合并高度近视参差性弱视的研究取得了一定进展.本文就视网膜有髓神经纤维合并高度近视参差性弱视的最新研究进展加以综述.

简介：由中国科学评价中心,武汉大学图书馆及中国科教评价网联袂研发的《中国学术期刊评价研究报告》——RCCSE权威期刊,核心期刊排行榜与指南于2011年8月由科学出版社正式出版,这在国内外期刊评价史上具有新的里程碑意义。