简介:Anewsyntheticapproachto1,4,6-tri-O-benzylmyo-inositolwasdescribedonthebasisoftheregioselectivebenzylationof1,2-O-isopropylidene-4,6-di-O-benzylmyo-inositol,subsequentacidhydrolysis,phosphorylationwithtetrabenazylpyrophosphateandappropriatedeprotec-tion.
简介:Thepulsed-sprayfluid-bedgranulation(PSFBG)processwasinvestigatedandoptimizedusingdefinitivescreeningdesign,arecentlyproposednewclassofthree-leveldesignofexperimentmethod.Suchadesignenabledquadraticmodelstobeestablishedthatdescribedtheeffectofsixinputprocessparameters-inletairtemperature,inletairhumidity,bindersprayrate,atomizationpressure,pulseperiod,andpulsewidth-onthegranulequalityinaPSFBGprocess.Mathematicalmodelsofthemeanparticlesize,relativesizedistributionwidth,productionyield,andporosityweredevelopedtoquantifytherelationshipsbetweentheinfluencingfactorsandcriticalqualityattributes.Onthebasisofconstraintsonthedesiredgranuleproperties,adesignspaceforPSFBGwasdeterminedandrangesoftheoperatingparametersweredefined.Anacceptabledegreeofpredictionwasconfirmedbyvalidationexperiments,demonstratingthereliabilityandeffectivenessofusingdefinitivescreeningdesigntostudythePSFBGprocess.Thismethodcanacceleratescreeningandoptimizationofthisprocesswithinalargemultidimensionaldesignspace.
简介:AinteriorpointscalingprojectedreducedHessianmethodwithcombinationofnonmonotonicbacktrackingtechniqueandtrustregionstrategyfornonlinearequalityconstrainedoptimizationwithnonegativeconstraintonvariablesisproposed.Inordertodealwithlargeproblems,apairoftrustregionsubproblemsinhorizontalandverticalsubspacesisusedtoreplacethegeneralfulltrustregionsubproblem.Thehorizontaltrustregionsubprobleminthealgorithmisonlyageneraltrustregionsubproblemwhiletheverticaltrustregionsubproblemisdefinedbyaparametersizeoftheverticaldirectionsubjectonlytoanellipsoidalconstraint.Bothtrustregionstrategyandlinesearchtechniqueateachiterationswitchtoobtainingabacktrackingstepgeneratedbythetwotrustregionsubproblems.Byadoptingthel1penaltyfunctionasthemeritfunction,theglobalconvergenceandfastlocalconvergencerateoftheproposedalgorithmareestablishedundersomereasonableconditions.AnonmonotoniccriterionandthesecondordercorrectionstepareusedtoovercomeMaratoseffectandspeeduptheconvergenceprogressinsomeill-conditionedcases.
简介:约束传播算法是求解约束满足问题的一种重要方法.调度问题是一种特殊的约束满足问题.本文介绍了调度问题中的Edge-Finding和Energy-Reasoning两种分离约束传播算法,并对它们进行了比较,文中最后给出了一种结合Energy-Reasoning的Edge-Finding改进算法.
简介:建立了非紧FC-空间中新的连续选择定理,作为应用,获得了非紧FC-空间中广义模糊约束多目标对策的弱Pareto平衡存在定理.我们的结论统一、改进和推广了一些近期文献的已知结果.