简介:目的探讨30岁以下青年乳腺癌的临床病理学特征,以提高其诊断、治疗水平。方法回顾性分析1996-2003年收治的53例30岁以下青年乳腺癌的发生率、组织学类型、腋窝淋巴结转移及雌激素受体表达等临床病理学特征,并分析其预后。随机挑选本院同期100例乳腺癌(年龄〉30岁)作为对照组。结果30岁以下青年乳腺癌占同期全部乳腺癌的2.3%;53例30岁以下青年乳腺癌病例中,浸润性癌占84%;腋窝淋巴结转移率达69%;30岁以下青年组2年复发转移率为64%。30岁以下青年乳腺癌组的以上临床病理学参数与中老年乳腺癌组比较,有显著性差异(P〈0.005,P〈0.001);但两组激素受体厦Cerb-2基因表达差别无统计学意义。结论30岁以下青年乳腺癌有多项不同于中老年乳腺癌的临床病理学特征,顸后差。
简介:Objective:Toobservetheinfluenceofelectroacupuncture(EA)atdifferenttimeinadayonthenumberofduodenalendocrinecells(argentaffincells)inrats.Methods:Forty-eightmaleWistarratswereevenlyrandomizedintocontrolandelectroacupuncture(EA)groupswhichwerefurtherdividedinto5∶00,11∶00,17∶00and23∶00subgroupsrespectively.EA(4-16Hzinthefrequency,3Vinthestrength,intermittentdense-sparsewaves,anddurationof20min)wasappliedtobilateral"Huantiao"(环跳GB30)at5∶00o'clock,11∶00o'clock,17∶00o'clockand23∶00o'clockseparatelyfordifferentsubgroups.AfterEA,theanimalswerekilledatonceforsamplingthemiddlepartofduodenumwhichwasfixedin10%formalinfor2hours,thenembedinparaffin.Thetissuewascutintosections(10μm),mountedonglassslidesandthenprocessedaccordingtoGrimelius'smethods.Results:ThenumberofargentaffincellsinEAgroupwassignificantlyfewerthanthatincontrolgroupatthesametime-window(23∶00,P<0.05).NosignificantdifferenceswerefoundbetweencontrolandEAgroupsinthenumberofcellsatothertimewindow(5∶00,11∶00and17∶00o'clock,P>0.05),suggestingthatEAof"Huantiao"canmarkedlypromotethesecretionactivityofendocrinecellsat11∶00o'clockduringnight.Conclusion:TheresultssuggestthattheeffectsofEAaredifferentatdifferenttimewindowinaday.