简介：SulfatechitosanderivativeshavegoodsolubilityandtherapeuticeffectonthecellmodelofNAFLD.TheaimofthisstudywastoexaminethetherapeuticeffectofsulfatechitosanderivativesonNAFLD.ThemaleWistarratswereorallyfedhighfatemulsionandreceivedsulfatechitosanderivativesfor5weekstodeterminethepre-treatmenteffectofsulfatechitosanderivativesonNAFLD.ToevaluatethetherapeuticeffectofsulfatechitosanderivativesonNAFLD,theratswereorallyfedwithhighconcentrationemulsionfor5weeks,followedbysulfatechitosanderivativesfor3weeks.Histologicalanalysisandbiomedicalassaysshowedthatsulfatechitosanderivativescandramaticallypreventthedevelopmentofhepaticsteatosisinhepatocytecells.Inanimalstudies,pre-treatmentandtreatmentwithsulfatechitosanderivativessignificantlyprotectedagainsthepaticsteatohepatitisinducedbyhighfatdietaccordingtohistologicalanalysis.Furthermore,increasedTC,ALT,MDA,andLEPinNAFLDweresignificantlyamelioratedbypre-treatmentandtreatmentwithsulfatechitosanderivatives.Furthermore,increasedTG,AST,andTNF-αinNAFLDweresignificantlyamelioratedbytreatmentwithsulfatechitosanderivatives.Sulfatechitosanderivativeshavegoodpre-treatmentandtherapeuticeffectonNAFLD.

简介：Thispaperdealsmainlywithetiology,pathology,sympotomatology,harmfulness,preventivemeasuresandtreatmentoflarvalmycosis(causedbyLagenidiumsp.)andofciliatedisease(causedbyZoothamniumsp.)ofpenaeidshrimplarvae.

简介：Seacucumbers,ApostichopusjaponicusSelenka,werefeddietscontainingnon-immunostimulant(basaldiet),0.2%β-glucanand0.02%glycyrrhizininarecirculatorywatersystemfor45days,andsubsequentlychallengedwithVibriosplendidusbyinjectionat1.0×108cfu/seacucumberfor15days.Phagocyticcapacity(PC),intracellularsuperoxideanionproduction(ISAP),ly-sozyme(LSZ)activityandsuperoxidedismutase(SOD)activityinthecoelomicfluidwereanalyzedonthe0th,5th,10thand15thdaysafterinjection.Resultsshowedthatafterthe45-dayfeedingperiod,PC,ISAP,LSZactivityandSODactivityinseacucumbersfedwithdietaryβ-glucanorglycyrrhizinweresignificantlyhigherthaninthosefedwiththebasaldiet.Onthe5thdayafterinfection,alltheimmuneparametersexaminedintheseacucumbersinjectedwithV.splendidusdecreasedinvaluesignificantly.Onthe15thday,PC,ISAPandLSZactivityreturnedtolevelssimilartothoseonthe0thday.Fortheseacucumbersinjectedwithsaline,therewerenosignificantdifferencesinalltheimmuneparametersexaminedandinthecumulativemorbidityduringthe15-daychallengingtrial.AfterinjectingwithV.splendidus,thecumulativemorbidityofseacucumbersfedwiththebasaldietwassignificantlyhigherthanthosefedwithdietaryβ-glucanorglycyrrhizinwhenchallengedwithV.splendiduschallengedseacucumberfedwiththebasaldietwassignificantlyhigherthanthosefedwithdietaryβ-glucanorglycyrrhizin.Therewasnosignificantdifferenceincumulativemorbiditybetweenthedietaryβ-glucanandglycyrrhizintreatmentsovertime.