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简介：赛灵思公司近期成功将其Zynq-7000A11ProgrammableSoC系列的峰值处理性能提升至1GHz,同时还将采用更小的封装尺寸以实现更高的系统性能和可编程系统集成度。上述增强功能可进一步提高众多高端影像与图形处理应用的系统价值,从而充分满足医疗以及有线与无线设备领域计算密集型系统的要求。

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简介：AbstractBackground:It is currently unknown whether patients with a fever after controlled ovulation during egg retrieval could increase the risk of pelvic infection or not, and fever itself may affect endometrial receptivity or embryo quality with poor pregnancy outcomes. The aim of this study was to analyze the outcomes of patients with fever during oocyte retrieval after the first frozen-thawed embryo transfer (FET) cycle.Methods:This was a 1:3 retrospective paired study matched for age. In this study, 58 infertility patients (Group 1) had a fever during the control ovulation, and the time of the oocyte retrieval was within 72 hours, they underwent ovum pick up and whole embryo freezing ( "freeze-all" strategy). The control subjects (Group 2) are 174 patients matched for age who underwent whole embryo freezing for other reasons. The baseline characteristics, clinical data of ovarian stimulation, and outcomes, such as the clinical pregnancy rate, ongoing clinical pregnancy rate were compared between the two groups in the subsequent FET cycle.Results:All patients had no pelvic inflammatory disease after oocyte retrieval. Anti-Mullerian hormone (AMH) levels (4.2 vs. 2.2, P <0.001) were higher in group 2, and the number of oocytes retrieved, and fertilization rate were lower in group 1 (P < 0.001), but the endometrial thickness, the number of embryo transfers, and the type of luteal support supplementation were similar between the two groups. Regarding pregnancy outcomes in the subsequent FET cycle, the implantation rate, clinical pregnancy rate, early spontaneous rate, ectopic pregnancy rate, and ongoing pregnancy rate were all not significantly different. Further regression analyses showed that the clinical pregnancy rate and ongoing pregnancy rate were also not significantly different.Conclusions:Transvaginal ultrasound-guided follicular puncture for oocyte retrieval is a safe and minimally invasive method for patients with fever. Moreover, the fever had almost no effect on embryo quality.

简介：Wepresentanovelandsimplemethodtoobtainanultrawidefreespectralrange(FSR)siliconringresonatortogetherwithatuningrangecoveringtheentirespectrumfrom1500to1600nm.AringresonatorwithalargeFSRtogetherwithahighQfactor,hightuningefficiency,andlowfabricationcostandcomplexityisdesiredformanyapplications.Inthispaper,weintroduceanovelwaytomakesucharingresonator,whichtakesadvantageofthewell-knownresonance-splittingphenomenon.ItisasingleringresonatorwithanFSRofmorethan150nmaround1550nmandwhichhasaneasythermo-optictunabilitythatcanproduceatuningrangearound90nmorevenmore.Moreover,thedeviceissimpletoimplementandcanbefabricatedinstandardcomplementarymetal-oxidesemiconductortechnologywithoutrequiringanykindofcomplicatedprocessingorextramaterials.Thepotentialapplicationsincludesinglemodelasercavities,wavelengthdivisionmultiplexingfilters,(de)multiplexers,opticalsensors,andintegratedreflectors.

简介：摘要目的探讨抗胰岛素生长因子Ⅰ型受体（IGF-ⅠR）单克隆抗体对ALL细胞株细胞周期的影响。方法以ALL细胞株Jurkat及Reh为研究对象，用浓度分别为0和lμg/ml的抗IGF-ⅠR单克隆抗体（ab16890）及胰岛素（10-8mol/L）共培养两种细胞株各48h，收集两组细胞，以70％乙醇2ml4℃固定24h，上机检测两组的细胞周期。结果以1μg/ml的ab16890及胰岛素共同作用于Jurkat及Reh细胞后，与对照组相比，G0/G1期的细胞明显增多（P值均小于0.05），说明加药后使两种细胞株均阻滞在G0/G1期。结论抗IGF-ⅠR单克隆抗体（ab16890）可诱导两种ALL细胞株凋亡并使细胞阻滞在G0/G1期。

简介：摘要目的探讨中国儿童急性淋巴细胞白血病2008（NPCLC-ALL2008）方案治疗儿童急性T淋巴细胞白血病（T-ALL）的效果。方法回顾性分析2009年1月至2017年12月在浙江大学医学院附属儿童医院血液肿瘤中心接受NPCLC-ALL2008方案进行规范治疗的96例T-ALL患儿的临床资料。分析流式细胞术监测微小残留病（MRD）与预后的关系，应用Kaplan-Meier法进行长期生存分析。结果96例T-ALL患儿中男72例、女24例，年龄9.5（1.0~16.0）岁，随访时间5.7（1.0~9.7）年。92例患儿获得完全缓解（96%），5年无事件生存率（EFS）和总生存率（OS）分别为（61±6）%和（70±5）%，复发18例，5年累积复发率（27±6）%，死亡24例。诱导第15天MRD>5%者生存率明显低于MRD≤5%者，5年OS分别为（60±12）%和（72±6）%（χ2=3.904, P=0.048），巩固治疗前MRD>10%者5年EFS和OS均明显降低，均为（50±35）%。复发患儿生存明显差于无复发患儿，5年OS分别为（26±13）%和（81±5）%（χ2=18.411, P<0.01），复发时间越早预后越差，诊断6个月内复发者5年OS仅为（25±22）%，3年内和3年以上复发者5年OS分别为（30±14）%和（50±35）%，差异有统计学意义（χ2=13.207, P<0.01）。结论NPCLC-ALL2008方案治疗T-ALL疗效尚可，MRD指导下进行精确的危险分层和个性化治疗来减少复发有望进一步提高T-ALL患儿长期生存率。

简介：摘要目的分析成人费城染色体阴性急性淋巴细胞白血病(ALL)移植后复发的影响因素。方法总结南方医科大学南方医院血液科2016年至2018年期间，接受异基因造血干细胞移植(allo-HSCT)的成人费城染色体阴性ALL患者移植前后临床资料，进行回顾性分析。65例费城染色体阴性成人ALL接受首次allo-HSCT的患者，男性37例，女性28例，年龄14～58岁，中位年龄25岁。结果中位随访27个月，2年的总存活(OS)率为78.8%(95%CI 67.8%～89.8%)，2年的无复发生存(RFS)率为70.7%(95%CI 58.2%～83.2%)；移植前化学药物治疗3～7疗程(中位数4疗程)，培门冬酶中位剂量为3剂(2 000 IU/m2，每次1剂)。多因素分析发现，强化培门冬酶组(移植前化疗方案中培门冬酶剂量≥4剂)是移植后复发的保护性因素(HR＝4.067，P＝0.046)，高危染色体核型是移植后复发的高危因素(HR＝0.193，P＝0.009)。生存分析显示，强化培门冬酶组(32例)2年RFS显著高于对照组(33例)(90.0%，95%CI 79.2%～100%和56.9%，95%CI 39.1%～74.7%，P＝0.010)；两组间OS差异无统计学意义(90.6%，95%CI 80.4%～100%和72.1%，95%CI 56.6%～87.6%，P＝0.079)。结论强化培门冬酶的化疗方案可显著降低成人费城染色体阴性急性淋巴细胞白血病移植后的复发，提高无复发生存。

简介：摘要：随着高校数量的不断增多，以及一些学校的扩招，大学生数量也逐渐增多。而且这些学生对于网络信息的依赖性非常强。所以，笔者针对他们的需要和生活经验，设计出了一款校园生活服务APP——“enjoy all”。希望能为他们的学习和生活带来更多便利，并且展现出丰富多彩的校园生活，通过交友圈促进他们的良性互动、交流。

简介：OnDecember18,1979,the34thGeneralAssemblyoftheUnitedNationsadoptedtheConventionontheEliminationofAllFormsofDiscriminationagainstWomenwithanoverwhelmingmajorityofthevotesinitsfavor.Overthepast30years,theConventionhascometo

简介：Wedemonstrateanintegratedall-fibermid-infrared（mid-IR）supercontinuum（SC）sourcegeneratedbya1.95μmmasteroscillatorpoweramplifiersystemandasingle-modeZBLAN（ZrF4–BaF2–LaF3–AlF3–NaF）fiber.Themaximumaverageoutputpoweris10.67Wwithspectralbandwidthcoveringfrom～1.9to4.1μm.Thesingle-modeZBLANfiberandsilicafiberarethermal-splicedtoenhancetherobustnessandpracticabilityofthesystem.Itis,tothebestofourknowledge,thefirsthigh-powerintegratedcompactedall-fibermid-IRSCsourcebasedonthermal-splicedsilicafiberandZBLANfiber.

简介：WedemonstrateastableconventionalsolitoninaTm-dopedhybridmode-lockedfiberlaserbyemployingahomemadeall-fiberLyotfilter(AFLF)andasingle-wallcarbonnanotube.TheAFLF,designedbysandwichingapieceofpolarization-maintainedfiber(PMF)withtwo45°tiltedfibergratingsinscribedbyaUVlaserinPMFwithaphase-maskscanningtechnique,showslargefilterdepthof~9dBandsmallinsertionlossof~0.8dB.ByoptimizingthefreespectralrangeoftheAFLF,theKellysidebandsofaconventionalsolitoncenteredat1966.4nmcanbedramaticallysuppressedwithoutimpairingthemainshapeofthesolitonspectrum.Itgivesthepulsedurationof1.18psandbandwidthof3.8nm.ByadjustingthetemperatureofthePMFoftheAFLFfrom7°Cto60°C,wavelengthtunablesolitonpulsesrangingfrom1971.62nmto1952.63nmarealsoobtained.Thegeneratedsolitonpulsescanbepreciselytunedbetween1971.62nmand1952.63nmbycontrollingthetemperatureoftheAFLF.

简介：摘要目的比较二代酪氨酸激酶抑制剂(TKI)达沙替尼联合异基因造血干细胞移植(allo-HSCT)或化学药物治疗费城染色体阳性急性淋巴细胞白血病(Ph＋ALL)的疗效差异。方法回顾分析2014年1月至2018年6月郑州大学第一附属医院血液内科收治的应用达沙替尼治疗Ph＋ALL患者56例；根据是否行allo-HSCT分为移植组22例和化疗组34例，随访时间22个月(3～50个月)，比较两组患者的总存活(OS)率、无病存活(DFS)率、复发及非复发死亡情况(NRM)，评价联合达沙替尼治疗时，allo-HSCT是否较化疗具有优越性。结果移植组和化疗组2年OS率分别为69.1 %和47.8 %(P＝0.032)，移植组和化疗组2年DFS率分别为62.2 %和43.1 %(P＝0.043)，移植组和化疗组2年累积复发率分别为14.6 %和44.1 %(P＝0.008)，两组间2年OS、DFS和累计复发率均有统计学差异；移植组非复发死亡率(NRM)高于化疗组(分别为18.6 %和14.1 %)，但差异无统计学意义(P＝0.476)。结论达沙替尼联合allo-HSCT治疗Ph＋ALL疗效优于达沙替尼联合化疗。

简介：以Electricityallaround的教学设计为例,结合学生对网络智能平台的兴趣,从技术和方法上引导学生利用翼课网平台辅助阅读教学过程,优化英语阅读课教学,体现了信息技术与英语阅读教学相融合的新型教学模式.

简介：歌词节选:你一开口就正合我意,这就是神奇的默契不言一语,就足以把黑暗驱离我千方百计,竟也道不出这种魔力就算静谧无言,我也能听到的天籁之语你脸上的笑意,让我笃定需要我的人是你你眼眸流转的真情,向我诉说你会不离不弃你掌心传来的温度,会在我跌倒时把我扶起一切尽在不言中,有此默契足矣

简介：Byusingtheultrasound-assistedliquidphaseexfoliationmethod,Bi2Te3nanosheetsaresynthesizedanddepositedontoaquartzplatetoformakindofsaturableabsorber（SA）,inwhichnonlinearabsorptionpropertiesaround2μmareanalyzedwithahome-mademode-lockedlaser.Withtheas-preparedBi2Te3SAemployed,astablepassivelyQ-switchedall-solid-state2μmlaserissuccessfullyrealized.Q-switchedpulseswithamaximumaverageoutputpowerof2.03Waregeneratedunderanoutputcouplingof5%,correspondingtothemaximumsingle-pulseenergyof18.4μJandpeakpowerof23W.Thedeliveredshortestpulsedurationandmaximumrepetitionrateare620nsand118kHzunderanoutputcouplingof2%,respectively.ItisthefirstpresentationofsuchBi2Te3SAemployedinasolid-stateQ-switchedcrystallinelaserat2μm,tothebestofourknowledge.Incomparisonwithother2Dmaterialssuitableforpulsed2μmlasers,thesaturableabsorptionperformanceofBi2Te3SAisprovedtobepromisingingeneratinghighpowerandhigh-repetition-rate2μmlaserpulses.

简介：Theeffectandmechanismofcarmustine(BCNU)combinedwithall-transretinoicacid(ATRA)ontheapoptosisofhumanglioblastomaU251cellswereinvestigatedbymeansof3-(4,5-dimethylthiazol-2-yl)-2,5-diphe-nyltetrazoliumbromide(MTT)assay,flowcytometry,reversetranscription-polymerasechainreaction(RT-PCR)andWesternblotanalysis.TheresultsshowthatBCNUorATRAshowstime-anddose-dependentinhibitioneffectsonhumanglioblastomaU251cellsandthecombinationofBCNUwithATRAshowsansynergisticinhibitioneffectonhumanglioblastomaU251cells,andthecombinedBCNUandATRAcansignificantlyinhibittheproliferationofhumanglioblastomaU251cells,andinducetheapoptosisofthem,makingthecellsarrestinthestageofG1phase,thestageofSandG2phasesdecline,therateoftheapoptosisofhumanglioblastomaU251cellsincrease,thecorrespondingmRNAexpressionofcyclinEandcyclin-dependentkinase2(CDK2)downregulatedandthecorrespon-dingmRNAexpressionofp27kip1unregulated.Inaddition,thecombinedBCNUandATRAreducedtheproteinexpressionofnuclearfactorkappaB(NF-κB).Takentogether,theseresultssuggestthatthetreatmentofhumanglioblastomaU251cellswithacombinationapplicationofATRAandBCNUcanexertsynergisticeffect,thecourseofthiskindofcombinationchemotherapymaylikelybeassociatedwithmultiplemolecularmechanismsforapoptosis,furthermore,thecyclinEandp27kip1shouldbeconsideredasnoveltargetsforcontrollingthegrowthofglioblastomacells.

简介：在旅行波浪转变下面，一些非线性的部分微分方程例如Camassa河边肥沃的低地方程，高顺序的KdV方程，等等，被归结为u″表示的一首integrable颂诗+p(u)(u')2+q(u)=0答案能被给其将军。而且，为多项式联合完全的辨别系统，这些方程的所有单个旅行波浪答案的分类被获得。方程u″0包括的+p(u)(u')2+q(u)=是的方程(u')2=f(u)一种特殊情况，建议方法能也因此被用于很多非线性的方程。这些完全的结果不能被任何间接方法获得。

简介：Wedemonstrateadiode-pumpTm3+t-dopedall-fiberlaseroperatingat1908nmbasedonamasteroscillatorpoweramplifier（MOPA）configuration.Inourwork,152Woflaseroutputpowerisgeneratedbyatotalincidentpumppowerof434Wat790nm,correspondingtothetotalopticalefficiencyof35%.Thelaserwavelengthis1908.29nm.Tothebestofourknowledge,itisthehighestoutputpowerreachedaround1908nmwithsuchanarrowlinewidthof0.18nmbasedonaMOPAconfiguration.