简介：褐和绿色的生活桌子渲染英语谷物蚜虫，在20±1°C在实验室条件下面在大麦上饲养的Sitobionavenae(赘言作家)，65%±5%亲戚湿度和16:8h的一个光周期的morphs(L:D)被比较。植物是任何一个：感染大麦黄矮子病毒(BYDV)的(i)；(ii)没与病毒感染，但是以前与蚜虫大批出没于；或(iii)健康大麦植物，它不是以前与蚜虫大批出没于。通常，两个都渲染S的morphs。当在感染BYDV的植物上喂了时，avenae比在植物上那是免费的病毒，但是也一直不是或是的更好显著地表现了以前与蚜虫大批出没于。而且，当在感染BYDV的植物上喂了时，绿S。avenae更快显著地发展了并且比棕色的颜色morph有一个显著地更短的繁殖时期。在在S的二颜色morphs之间的这个方面没有重要差别。avenae他们什么时候在也是的没有病毒的植物上被扶养，是以前与蚜虫大批出没于。这些结果显示感染BYDV的那棵大麦比为两个的uninfected大麦是更有利的主人植物S的颜色morphs。测试的avenae，特别地绿颜色morph。

简介：我们与高风险的前列腺癌症在271个病人报导全面的率，地点和积极外科的边缘(PSM)的预兆的因素。在2008年4月和2011年10月之间，我们有希望地从作为D'Amico分类的病人收集了数据高风险经历了帮助机器人的laparoscopic激进分子前列腺切除术。PSM的全面的率和地点被报导。逐步的逻辑回归模型被适合估计PSM的预兆的因素。PSM的全面的率是25.1%(271个病人中的68个)。这些PSM，(68中的26个)38.2%是posterolateral(PL)，26.5%(68中的18个)multifocal，16.2%(68中的11个)在顶，14.7%(68中的10个)在膀胱颈，并且4.4%(3/68)在另外的地点。有病理学的阶段pT2的病人的PSM率是8.6%(140中的12个)，26.6%(64中的17个)pT3a，53.3%(32/60)pT4的pT3b，和100%(7中的7个)。在包括pre-，intra-，和手术后的参数的一个逻辑回归模型，身体团索引(机会比率[或]：1.09；95%信心间隔[CI]：1.01-1.19，P=0.029)，病理学的舞台(pT3b或更高对pT2；或：5.14；95%CI：1.92-13.78；P=0.001)并且肿瘤的百分比(或：46.71；95%CI：6.37-342.57；P<0.001)是为PSM的独立预兆的因素。在病人在的PSM的最普通的地点高风险是PL方面，它反映报导肿瘤攻击性。PSM的唯一的重要预兆的因素是病理学的结果，例如在标本和病理学的舞台的肿瘤的百分比。

简介：AbstractBackground:Resting heart rate (RHR) is considered as a strong predictor of total mortality and hospitalization due to heart failure in hypertension patients. Bisoprolol fumarate, a second-generation beta-adrenoreceptor blockers (β-blocker) is commonly prescribed drug to manage hypertension. The present study was to retrospectively evaluate changes in the average RHR and its association with cardiovascular outcomes in bisoprolol-treated coronary artery disease (CAD) patients from the CAD treated with bisoprolol (BISO-CAD) study who had comorbid hypertension.Methods:We performed ad-hoc analysis for hypertension sub-group of the BISO-CAD study (n = 866), which was a phase IV, multination, multi-center, single-arm, observational study carried out from October 2011 to July 2015 across China, South Korea, and Vietnam. Multivariate regression analysis was used to identify factors associated with incidence of composite cardiac clinical outcome (CCCO), the results were presented as adjusted odds ratio (OR) along with 95% confidence interval (CI) and adjusted P value.Results:A total of 681 patients (mean age: 64.77 ± 10.33 years) with hypertension from BISO-CAD study were included in the analysis. Bisoprolol improved CCCOs in CAD patients with comorbid hypertension, with RHR <65 and <70 beats/min compared with RHR ≥65 and ≥75 beats/min, respectively, in the efficacy analysis (EA) set. In addition, it lowered RHR in both intent-to-treat (ITT) and EA groups after 6, 12, and 18 months of treatment. Further, RHR 70 to 74 beats/min resulted in significantly higher risk of CCCOs EA set of patients (adjusted OR: 4.34; 95% CI: 1.19-15.89; P = 0.03). Also, events of hospitalization due to acute coronary syndrome were higher when RHR 69 to 74 beats/min compared to RHR <69 beats/min in ITT patients.Conclusion:Bisoprolol can effectively reduce RHR in Asian CAD patients with comorbid hypertension and hence, improve CCCO without affecting their blood pressure.

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简介：AbstractBackground:One inevitable shortcoming of non-invasive prenatal screening (NIPS)/cell-free DNA (cfDNA) sequencing is the uninterpretable ( "no-call" ) result, which is mainly caused by an insufficient fetal fraction. This study was performed to investigate the factors associated with a successful second NIPS in these cases and determine the optimal management for women with initial no-call results.Methods:We retrospectively analyzed the data of women who underwent NIPS with initial no-call results due to an insufficient fetal fraction from 2017 to 2019 in our center. We compared these women’s maternal and pregnancy information with the data of women who had attained a successful second NIPS result and women who had received no-call results for a second time.Results:Among the 33,684 women who underwent NIPS, 137 with a no-call result underwent a retest. Comparison between the 87 (63.50%) women with a successful retest and the other 50 (36.50%) women showed a significant difference in both the initial fetal fraction and maternal body mass index (BMI), whereas the other factors showed no significant differences. In addition, with an initial fetal fraction of < 2.00%, the retest success rate was very limited.Conclusions:We identified two major factors associated with a successful NIPS retest: the initial fetal fraction and the maternal BMI. These findings suggest the need for specialized management for this subset of women and would be instructional for the counseling for these women.

简介：Wedemonstratedstablemidinfrared(MIR)opticalfrequencycombatthe3.0μmregionwithdifferencefrequencygenerationpumpedbyahighpower,Er-doped,ultrashortpulsefiberlasersystem.Asolitonmode-locked161MHzhighrepetitionratefiberlaserusingasinglewallcarbonnanotubewasfabricated.TheoutputpulsewasamplifiedinanEr-dopedsinglemodefiberamplifier,anda1.1–2.2μmwidebandsupercontinuum(SC)withanaveragepowerof205mWwasgeneratedinhighlynonlinearfiber.ThespectrogramofthegeneratedSCwasexaminedbothexperimentallyandnumerically.ThegeneratedSCwasfocusedintoanonlinearcrystal,andstablegenerationofMIRcombaroundthe3μmwavelengthregionwasrealized.

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简介：在这份报纸，消极地切换Q、锁模式的c切割在1.17m的做Nd的vanadate水晶self-Raman激光被使用Cr第一表明<啜class=“a-plus-plus”>4+:YAG。Nd的二晶体<啜class=“a-plus-plus”>3+:YVO4和Nd<啜class=“a-plus-plus”>3+:GdVO4被采用分别地产生激光。与13W的事件泵力量，在1.17m的678mW和852mW的平均产量力量分别地与1.8ns和2ns的切换Q的信封的持续时间被获得。锁模式的重复率分别地象2.3Hz和2.2GHz一样高。根据我们知道，切换Q的信封是最狭窄并且锁模式的重复率是最高目前在这块地里。另外，黄激光输出被使用解放也完成<潜水艇class=“a-plus-plus”>3O<潜水艇class=“a-plus-plus”>5频率加倍水晶。

简介：客观：为了探索病理和临床的反应率的变化，为非小的房间肺癌症与MVP政体由neoadjuvant化疗对待。方法：这是在有阶段I-IIIa的病人的使随机化的研究。在他们之中，46个病人在neoadjuvant注册了1鈥对待的化疗吗？功课MVP政体。MMC被给6mg/M2由静脉内(I.V)day1上的注入，VDS2.5鈥吗？day1,8或day15上的mg/M2I.V，day1上的DDP90mg/M2I.V。治疗每28天被再循环。评估与的临床的RR标准。所有外科的样品与病理被分类。结果：在2功课化疗的全面反应率在1堂功课比那好(P<0.01)。有病理等级的病人的数字我在2功课化疗的鈥揑I比那高嗨1堂功课(P<0.01)。但是RR不能完全翻译了成病理等级我鈥揑I。病理等级我鈥揑I仔细与肿瘤参与(T)被联系(P<0.01)然而并非与地区性的淋巴节点转移(N)密切相关。和PCR使用RR判定化疗反应是合理的。NR病人不能作为化疗失败是问候。不服务毒性和外科的死亡被观察。结论：MVP政体是为I-IIIaNSCLC的有效neoadjuvant治疗政体。

简介：Newvisibletransparent,UVabsorption,andhighinfraredreflectionpropertieshavebeenrealizedbydepositingmultilayerSiO2/ZnO：Al/CeO2-TiO2/SiO2filmsontoglasssubstratesatlowtemperaturebyradiofrequencymagnetronsputtering.OptimumthicknessofSiO2,ZnO：Al（ZAO）andCeO2-TiO2（CTO）filmsweredesignedwiththeaidofthinfilmdesignsoftware.Thedegreeofantireflectioncanbecontrolledbyadjustingthethicknessandrefractiveindex.TheouterSiO2filmcandiminishtheinterferencecoloringandincreasethetransparency;theinnerSiO2filmimprovestheadhesionofthecoatingontheglasssubstrateandpreventsCa2＋,Na＋intheglasssubstratefromenteringtheZAOfilm.Theaveragetransmittanceinthevisiblelightrangeincreasesbynearly18%-20%,ascomparedtodoublelayerZAO/CTOfilms.Andthefilmsdisplayhighinfraredreflectionrateofabove75%inthewavelengthrangeof10-25μmandgoodUVabsorption（〉98%）properties.Thesesystemsareeasytoproduceonalargescaleatlowcostandexhibithighmechanicalandchemicaldurability.ThetriplefunctionalfilmswithhighUVabsorption,antireflectiveandhighinfraredreflectionratewilladapttoapplicationinflatpaneldisplayandarchitecturalcoatingglass,automotiveglass,withdiminishinglightpollutionaswellasdecreasingeyefatigueandincreasingcomfort.

简介：Wehavedemonstratedahigh-average-power,high-repetition-rateopticalterahertz（THz）sourcebasedondifferencefrequencygeneration（DFG）intheGaSecrystalbyusinganear-degenerate2μmintracavityKTPopticalparametricoscillatorasthepumpsource.Thepowerofthe2μmdual-wavelengthlaserwasupto12.33Wwithcontinuoustuningrangesof1988.0–2196.2nm/2278.4–2065.6nmfortwowaves.DifferentGaSecystallengthshavebeenexperimentallyinvestigatedfortheDFGTHzsourceinordertooptimizetheTHzoutputpower,whichwasingoodagreementwiththetheoreticalanalysis.Basedonan8mmlongGaSecrystal,theTHzwavewascontinuouslytunedfrom0.21to3THz.ThemaximumTHzaveragepowerof1.66μWwasobtainedatrepetitionrateof10kHzunder1.48THz.Thesinglepulseenergyamountedto166pJandtheconversionefficiencyfrom2μmlasertoTHzoutputwas1.68×10-6.Thesignal-to-noiseratioofthedetectedTHzvoltagewas23dB.TheacceptanceangleofDFGintheGaSecrystalwasmeasuredtobe0.16°.

简介：Adiode-end-pumpedelectro-optic(EO)Q-switchedNd:YVO4laseroperatingatrepetitionrateof10kpps(pulsespersecond)wasreported.AblockofLa3Ga5SiO14(LGS)singlecrystalwasusedasaQ-switchandthedriverwasametaloxidesemiconductorfieldeffecttransistor(MOS-FET)pulserofhighrepetitionrateandhighvoltage.Atcontinuouswave(CW)operation,theslopeefficiencyofthelaserwas46%,andmaximumoptical-to-opticalefficiencywas38.5%.Usinganoutputcouplerwithtransmissionof70%,a10-kppsQ-switchedpulsetrainwith0.4-mJmonopulseenergyand8.2-nspulsewidthwasachieved,theopticalconversionefficiencywasaround15%,andthebeamqualityM2factorwaslessthan1.2.