简介：AIM:Toexploretheeffectsandmechanismofvascularendothelialcadherin(VE-cadherin)onexperimentalcornealneovascularization(CRNV).·METHODS:MousecorneaswereburnedwithsodiumhydroxidetobuildaCRNVmodel.Theburnedcorneaswerelocallyadministratedwithanti-mouseVE-cadherinneutralizingantibody.AnnexinVandclusterofdifferentiation31(CD31)doublestainingwasusedtomeasurevascularendothelialcellapoptosiswiththeuseofflowcytometry(FCM).TheproteinexpressionofNADPHoxidase2(Nox2),caspase-3,andproteinkinaseC(PKC)intheburnedcorneaswereexaminedbyWesternblot.Humanretinalendothelialcell(HREC)proliferationwasdetectedusingaCellCountingKit8(CCK-8)assayinvitro.·RESULTS:TheamountofCRNVpeakedtwoweeksafterthealkaliburn.FCMconfirmedthatVE-cadherinneutralizingantibodytreatmentincreasedCD31positivecellapoptosis.WesternblotrevealedthattheintracornealproteinexpressionofNox2andcaspase-3wereup-regulated,whilePKCwasdown-regulatedintheVE-cadherinneutralizingantibodyadministratedgroup.CCK-8assayshowedthatVE-cadherinneutralizingantibodymarkedlyinhibitedHRECproliferation.·CONCLUSION:VE-cadherinexhibitedananti-apoptosiseffectthroughenhancedPKCsignalingandanenhancedcellproliferationpathway.

简介：泪囊鼻腔吻合术"工"字型吻合法[1]是治疗慢性泪囊炎的常用方法,但它对泪囊已有纤维改变且与周围组织粘连以及泪囊较小者的手术效果较差.我科自1996年以来,用Kasper法[2]即不缝合黏膜瓣法,手术治疗慢性泪囊炎患者11例,收到满意效果,现报导如下.

简介：目的探讨鼻内镜下治疗突至上颌窦上颌骨囊肿的可行性和有效性。方法对11例突至上颌窦上颌骨囊肿在鼻内镜下行下鼻道进路的上颌骨囊肿开放术,对合并鼻腔底病变者同时行鼻腔底开放手术,切除部分囊壁。结果随访1~99个月,平均39个月,所有囊肿无复发。结论鼻内镜下治疗突至上颌窦或上颌窦合并鼻腔底的上颌骨囊肿简单易行、创伤小。